The effect of Jamblang (Syzygium cumini) leaves extract on serum creatinine level at rats induced by lead acetate

Lead (Pb) is a toxic metal element that affects various organ functions in the body, especially in the kidneys. Jamblang leaves contain various phytochemical compounds which act as antioxidants. This study aims to determine the effect of giving jamblang leaves extract (Syzygium cumini) on serum creatinine levels of rats (Rattus norvegicus) Wistar strain with lead acetate induction. This research is an experimental-research that used 24 male rats which were divided into 3 groups, namely the negative control (K-), positive control (K+), and treatment (P). The K-group was given standard feed, K+ was induced with lead acetate at a dose of 40 mg/kgBB, and the treatment group (P) was induced with lead acetate at a dose of 40 mg/kgBB and jamblang leaves extract at a dose of 150 mg/kgBB using an oral probe for 30 days. Serum creatinine examination using Micro Lab 300 by Jaffe Reaction method. Data is analyzed by One Way Anova. The average serum creatinine level obtained in the K-group was 0.52±0.09, K+ was 0.80±0.08, and P was 0.49±0.07. It can be concluded that jamblang leaves extract affects the serum creatinine levels of rats induced by lead acetate.