Evaluation of the radiofrequency identification lung marking system: a multicenter study in Japan
Background The radiofrequency identification (RFID) lung marking system is a novel technique using near-field radio-communication technology. The purpose of this study was to investigate the utility and feasibility of this system in the resection of small pulmonary nodules. Methods We retrospectivel...
Gespeichert in:
| Veröffentlicht in: | Surgical endoscopy 2023-05, Vol.37 (5), p.3619-3626 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3626 |
|---|---|
| container_issue | 5 |
| container_start_page | 3619 |
| container_title | Surgical endoscopy |
| container_volume | 37 |
| creator | Miyahara, So Waseda, Ryuichi Ueda, Yuichirou Yutaka, Yojiro Date, Hiroshi Suzuki, Jun Oizumi, Hiroyuki Goto, Masashi Nakagawa, Tatsuo Kojima, Fumitsugu Takenaka, Masaru Tanaka, Fumihiro Sato, Toshihiko |
| description | Background
The radiofrequency identification (RFID) lung marking system is a novel technique using near-field radio-communication technology. The purpose of this study was to investigate the utility and feasibility of this system in the resection of small pulmonary nodules.
Methods
We retrospectively reviewed clinical records of 182 patients who underwent sublobar resection with the RFID marking system between March 2020 and November 2021 in six tertial hospitals in Japan. Target markings were bronchoscopically made within 3 days before surgery. The contribution of the procedure to the surgery and safety was evaluated.
Results
Target nodule average diameter and depth from the lung surface were 10.9 ± 5.4 mm and 14.6 ± 9.9 mm, respectively. Radiologically, one third of nodules appeared as pure ground-glass nodules (GGNs) on CT. The average distance from target nodule to RFID tag was 8.9 ± 7.1 mm. All surgical procedures were completed by video-assisted thoracoscopic surgery. Planned resection was achieved in all cases without any complications. The surgeons evaluated this system as helpful in 93% (necessary: 67%, useful; 26%) of cases. Nodule radiological features (
p
|
| doi_str_mv | 10.1007/s00464-022-09858-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2808754832</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2808754832</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-3a588d521f5bba92591204030eb13588aded45ee48c088912e8ae6974f6a58233</originalsourceid><addsrcrecordid>eNp9kEtPwzAQhC0EoqXwBzggS5wDfiYON4TKS5W4wNlykk1xSZ1iO0j99xhS4MZpD_PN7O4gdErJBSWkuAyEiFxkhLGMlEqqTO2hKRWcZYxRtY-mpOQkY0UpJugohBVJfEnlIZrwPGeF5GqKzPzDdIOJtne4b3F8BexNY_vWw_sArt5i24CLtrX1CHWDW-K18W82zbANEdZX2OD10EVbJxI8DnFoks_hR7Mx7hgdtKYLcLKbM_RyO3--uc8WT3cPN9eLrOaFjBk3UqlGMtrKqjIlkyVlRBBOoKI8SaaBRkgAoWqiVBJBGcjLQrR5cjLOZ-h8zN34Pp0eol71g3dppWaKqEIKxVmi2EjVvg_BQ6s33qZ3tpoS_dWqHlvVqVX93apWyXS2ix6qNTS_lp8aE8BHICTJLcH_7f4n9hO9ZILc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2808754832</pqid></control><display><type>article</type><title>Evaluation of the radiofrequency identification lung marking system: a multicenter study in Japan</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Miyahara, So ; Waseda, Ryuichi ; Ueda, Yuichirou ; Yutaka, Yojiro ; Date, Hiroshi ; Suzuki, Jun ; Oizumi, Hiroyuki ; Goto, Masashi ; Nakagawa, Tatsuo ; Kojima, Fumitsugu ; Takenaka, Masaru ; Tanaka, Fumihiro ; Sato, Toshihiko</creator><creatorcontrib>Miyahara, So ; Waseda, Ryuichi ; Ueda, Yuichirou ; Yutaka, Yojiro ; Date, Hiroshi ; Suzuki, Jun ; Oizumi, Hiroyuki ; Goto, Masashi ; Nakagawa, Tatsuo ; Kojima, Fumitsugu ; Takenaka, Masaru ; Tanaka, Fumihiro ; Sato, Toshihiko</creatorcontrib><description>Background
The radiofrequency identification (RFID) lung marking system is a novel technique using near-field radio-communication technology. The purpose of this study was to investigate the utility and feasibility of this system in the resection of small pulmonary nodules.
Methods
We retrospectively reviewed clinical records of 182 patients who underwent sublobar resection with the RFID marking system between March 2020 and November 2021 in six tertial hospitals in Japan. Target markings were bronchoscopically made within 3 days before surgery. The contribution of the procedure to the surgery and safety was evaluated.
Results
Target nodule average diameter and depth from the lung surface were 10.9 ± 5.4 mm and 14.6 ± 9.9 mm, respectively. Radiologically, one third of nodules appeared as pure ground-glass nodules (GGNs) on CT. The average distance from target nodule to RFID tag was 8.9 ± 7.1 mm. All surgical procedures were completed by video-assisted thoracoscopic surgery. Planned resection was achieved in all cases without any complications. The surgeons evaluated this system as helpful in 93% (necessary: 67%, useful; 26%) of cases. Nodule radiological features (
p
< 0.001) and type of surgery (
p
= 0.0013) were associated with the degree of contribution. In most cases, identification of the RFID tag was required within 1 min despite adhesion (
p
= 0.27).
Conclusion
The RFID lung marking system was found to be safe and effective during successful sublobar resection. Patients with pure GGNs are the best candidates for the system.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-022-09858-8</identifier><identifier>PMID: 36627538</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abdominal Surgery ; Bronchoscopy ; Endoscopy ; Gastroenterology ; Gynecology ; Hepatology ; Hospitals ; Humans ; Identification ; Japan ; Lung ; Lung cancer ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - surgery ; Medicine ; Medicine & Public Health ; Multiple Pulmonary Nodules - diagnostic imaging ; Multiple Pulmonary Nodules - surgery ; Ostomy ; Patients ; Proctology ; Radio Frequency Identification Device ; Retrospective Studies ; Solitary Pulmonary Nodule - surgery ; Surgeons ; Surgery ; Thoracic surgery ; Thoracic Surgery, Video-Assisted - methods ; Tomography ; Tumors</subject><ispartof>Surgical endoscopy, 2023-05, Vol.37 (5), p.3619-3626</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-3a588d521f5bba92591204030eb13588aded45ee48c088912e8ae6974f6a58233</citedby><cites>FETCH-LOGICAL-c375t-3a588d521f5bba92591204030eb13588aded45ee48c088912e8ae6974f6a58233</cites><orcidid>0000-0002-2751-9465</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00464-022-09858-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00464-022-09858-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36627538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyahara, So</creatorcontrib><creatorcontrib>Waseda, Ryuichi</creatorcontrib><creatorcontrib>Ueda, Yuichirou</creatorcontrib><creatorcontrib>Yutaka, Yojiro</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><creatorcontrib>Suzuki, Jun</creatorcontrib><creatorcontrib>Oizumi, Hiroyuki</creatorcontrib><creatorcontrib>Goto, Masashi</creatorcontrib><creatorcontrib>Nakagawa, Tatsuo</creatorcontrib><creatorcontrib>Kojima, Fumitsugu</creatorcontrib><creatorcontrib>Takenaka, Masaru</creatorcontrib><creatorcontrib>Tanaka, Fumihiro</creatorcontrib><creatorcontrib>Sato, Toshihiko</creatorcontrib><title>Evaluation of the radiofrequency identification lung marking system: a multicenter study in Japan</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><addtitle>Surg Endosc</addtitle><description>Background
The radiofrequency identification (RFID) lung marking system is a novel technique using near-field radio-communication technology. The purpose of this study was to investigate the utility and feasibility of this system in the resection of small pulmonary nodules.
Methods
We retrospectively reviewed clinical records of 182 patients who underwent sublobar resection with the RFID marking system between March 2020 and November 2021 in six tertial hospitals in Japan. Target markings were bronchoscopically made within 3 days before surgery. The contribution of the procedure to the surgery and safety was evaluated.
Results
Target nodule average diameter and depth from the lung surface were 10.9 ± 5.4 mm and 14.6 ± 9.9 mm, respectively. Radiologically, one third of nodules appeared as pure ground-glass nodules (GGNs) on CT. The average distance from target nodule to RFID tag was 8.9 ± 7.1 mm. All surgical procedures were completed by video-assisted thoracoscopic surgery. Planned resection was achieved in all cases without any complications. The surgeons evaluated this system as helpful in 93% (necessary: 67%, useful; 26%) of cases. Nodule radiological features (
p
< 0.001) and type of surgery (
p
= 0.0013) were associated with the degree of contribution. In most cases, identification of the RFID tag was required within 1 min despite adhesion (
p
= 0.27).
Conclusion
The RFID lung marking system was found to be safe and effective during successful sublobar resection. Patients with pure GGNs are the best candidates for the system.</description><subject>Abdominal Surgery</subject><subject>Bronchoscopy</subject><subject>Endoscopy</subject><subject>Gastroenterology</subject><subject>Gynecology</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Identification</subject><subject>Japan</subject><subject>Lung</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple Pulmonary Nodules - diagnostic imaging</subject><subject>Multiple Pulmonary Nodules - surgery</subject><subject>Ostomy</subject><subject>Patients</subject><subject>Proctology</subject><subject>Radio Frequency Identification Device</subject><subject>Retrospective Studies</subject><subject>Solitary Pulmonary Nodule - surgery</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Thoracic surgery</subject><subject>Thoracic Surgery, Video-Assisted - methods</subject><subject>Tomography</subject><subject>Tumors</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kEtPwzAQhC0EoqXwBzggS5wDfiYON4TKS5W4wNlykk1xSZ1iO0j99xhS4MZpD_PN7O4gdErJBSWkuAyEiFxkhLGMlEqqTO2hKRWcZYxRtY-mpOQkY0UpJugohBVJfEnlIZrwPGeF5GqKzPzDdIOJtne4b3F8BexNY_vWw_sArt5i24CLtrX1CHWDW-K18W82zbANEdZX2OD10EVbJxI8DnFoks_hR7Mx7hgdtKYLcLKbM_RyO3--uc8WT3cPN9eLrOaFjBk3UqlGMtrKqjIlkyVlRBBOoKI8SaaBRkgAoWqiVBJBGcjLQrR5cjLOZ-h8zN34Pp0eol71g3dppWaKqEIKxVmi2EjVvg_BQ6s33qZ3tpoS_dWqHlvVqVX93apWyXS2ix6qNTS_lp8aE8BHICTJLcH_7f4n9hO9ZILc</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Miyahara, So</creator><creator>Waseda, Ryuichi</creator><creator>Ueda, Yuichirou</creator><creator>Yutaka, Yojiro</creator><creator>Date, Hiroshi</creator><creator>Suzuki, Jun</creator><creator>Oizumi, Hiroyuki</creator><creator>Goto, Masashi</creator><creator>Nakagawa, Tatsuo</creator><creator>Kojima, Fumitsugu</creator><creator>Takenaka, Masaru</creator><creator>Tanaka, Fumihiro</creator><creator>Sato, Toshihiko</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0002-2751-9465</orcidid></search><sort><creationdate>20230501</creationdate><title>Evaluation of the radiofrequency identification lung marking system: a multicenter study in Japan</title><author>Miyahara, So ; Waseda, Ryuichi ; Ueda, Yuichirou ; Yutaka, Yojiro ; Date, Hiroshi ; Suzuki, Jun ; Oizumi, Hiroyuki ; Goto, Masashi ; Nakagawa, Tatsuo ; Kojima, Fumitsugu ; Takenaka, Masaru ; Tanaka, Fumihiro ; Sato, Toshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-3a588d521f5bba92591204030eb13588aded45ee48c088912e8ae6974f6a58233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Abdominal Surgery</topic><topic>Bronchoscopy</topic><topic>Endoscopy</topic><topic>Gastroenterology</topic><topic>Gynecology</topic><topic>Hepatology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Identification</topic><topic>Japan</topic><topic>Lung</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple Pulmonary Nodules - diagnostic imaging</topic><topic>Multiple Pulmonary Nodules - surgery</topic><topic>Ostomy</topic><topic>Patients</topic><topic>Proctology</topic><topic>Radio Frequency Identification Device</topic><topic>Retrospective Studies</topic><topic>Solitary Pulmonary Nodule - surgery</topic><topic>Surgeons</topic><topic>Surgery</topic><topic>Thoracic surgery</topic><topic>Thoracic Surgery, Video-Assisted - methods</topic><topic>Tomography</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyahara, So</creatorcontrib><creatorcontrib>Waseda, Ryuichi</creatorcontrib><creatorcontrib>Ueda, Yuichirou</creatorcontrib><creatorcontrib>Yutaka, Yojiro</creatorcontrib><creatorcontrib>Date, Hiroshi</creatorcontrib><creatorcontrib>Suzuki, Jun</creatorcontrib><creatorcontrib>Oizumi, Hiroyuki</creatorcontrib><creatorcontrib>Goto, Masashi</creatorcontrib><creatorcontrib>Nakagawa, Tatsuo</creatorcontrib><creatorcontrib>Kojima, Fumitsugu</creatorcontrib><creatorcontrib>Takenaka, Masaru</creatorcontrib><creatorcontrib>Tanaka, Fumihiro</creatorcontrib><creatorcontrib>Sato, Toshihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyahara, So</au><au>Waseda, Ryuichi</au><au>Ueda, Yuichirou</au><au>Yutaka, Yojiro</au><au>Date, Hiroshi</au><au>Suzuki, Jun</au><au>Oizumi, Hiroyuki</au><au>Goto, Masashi</au><au>Nakagawa, Tatsuo</au><au>Kojima, Fumitsugu</au><au>Takenaka, Masaru</au><au>Tanaka, Fumihiro</au><au>Sato, Toshihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the radiofrequency identification lung marking system: a multicenter study in Japan</atitle><jtitle>Surgical endoscopy</jtitle><stitle>Surg Endosc</stitle><addtitle>Surg Endosc</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>37</volume><issue>5</issue><spage>3619</spage><epage>3626</epage><pages>3619-3626</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><abstract>Background
The radiofrequency identification (RFID) lung marking system is a novel technique using near-field radio-communication technology. The purpose of this study was to investigate the utility and feasibility of this system in the resection of small pulmonary nodules.
Methods
We retrospectively reviewed clinical records of 182 patients who underwent sublobar resection with the RFID marking system between March 2020 and November 2021 in six tertial hospitals in Japan. Target markings were bronchoscopically made within 3 days before surgery. The contribution of the procedure to the surgery and safety was evaluated.
Results
Target nodule average diameter and depth from the lung surface were 10.9 ± 5.4 mm and 14.6 ± 9.9 mm, respectively. Radiologically, one third of nodules appeared as pure ground-glass nodules (GGNs) on CT. The average distance from target nodule to RFID tag was 8.9 ± 7.1 mm. All surgical procedures were completed by video-assisted thoracoscopic surgery. Planned resection was achieved in all cases without any complications. The surgeons evaluated this system as helpful in 93% (necessary: 67%, useful; 26%) of cases. Nodule radiological features (
p
< 0.001) and type of surgery (
p
= 0.0013) were associated with the degree of contribution. In most cases, identification of the RFID tag was required within 1 min despite adhesion (
p
= 0.27).
Conclusion
The RFID lung marking system was found to be safe and effective during successful sublobar resection. Patients with pure GGNs are the best candidates for the system.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36627538</pmid><doi>10.1007/s00464-022-09858-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2751-9465</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0930-2794 |
| ispartof | Surgical endoscopy, 2023-05, Vol.37 (5), p.3619-3626 |
| issn | 0930-2794 1432-2218 |
| language | eng |
| recordid | cdi_proquest_journals_2808754832 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Abdominal Surgery Bronchoscopy Endoscopy Gastroenterology Gynecology Hepatology Hospitals Humans Identification Japan Lung Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - surgery Medicine Medicine & Public Health Multiple Pulmonary Nodules - diagnostic imaging Multiple Pulmonary Nodules - surgery Ostomy Patients Proctology Radio Frequency Identification Device Retrospective Studies Solitary Pulmonary Nodule - surgery Surgeons Surgery Thoracic surgery Thoracic Surgery, Video-Assisted - methods Tomography Tumors |
| title | Evaluation of the radiofrequency identification lung marking system: a multicenter study in Japan |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A27%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20the%20radiofrequency%20identification%20lung%20marking%20system:%20a%20multicenter%20study%20in%20Japan&rft.jtitle=Surgical%20endoscopy&rft.au=Miyahara,%20So&rft.date=2023-05-01&rft.volume=37&rft.issue=5&rft.spage=3619&rft.epage=3626&rft.pages=3619-3626&rft.issn=0930-2794&rft.eissn=1432-2218&rft_id=info:doi/10.1007/s00464-022-09858-8&rft_dat=%3Cproquest_cross%3E2808754832%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2808754832&rft_id=info:pmid/36627538&rfr_iscdi=true |