Fusarium verticillioides NAT1 (FDB2) N‐malonyltransferase is structurally, functionally and phylogenetically distinct from its N‐acetyltransferase (NAT) homologues

Fusarium endophytes damage cereal crops and contaminate produce with mycotoxins. Those fungi overcome the main chemical defence of host via detoxification by a malonyl‐CoA‐dependent enzyme homologous to xenobiotic metabolizing arylamine N‐acetyltransferase (NAT). In Fusarium verticillioides (teleomo...

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Veröffentlicht in:	The FEBS journal 2023-05, Vol.290 (9), p.2412-2436
Hauptverfasser:	Karagianni, Eleni‐Pavlina, Kontomina, Evanthia, Lowe, Edward D., Athanasopoulos, Konstantinos, Papanikolaou, Georgia, Garefalaki, Vasiliki, Kotseli, Varvara, Zaliou, Sofia, Grimaud, Tom, Arvaniti, Konstantina, Tsatiri, Maria‐Aggeliki, Fakis, Giannoulis, Glenn, Anthony E., Roversi, Pietro, Abuhammad, Areej, Ryan, Ali, Sim, Robert B., Sim, Edith, Boukouvala, Sotiria
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl Coenzyme A Acetyltransferase Acetyltransferases Amines Arylamine N-Acetyltransferase - chemistry Arylamine N-Acetyltransferase - genetics Cereal crops Chemical defense Crop damage Crystal structure Crystallography Detoxification Dimerization Endophytes Enzymes FDB2 Fungi Fusarium Fusarium - genetics Fusarium verticillioides Homology Hydrogen bonding Hydrogen bonds Isoenzymes Isoenzymes - genetics malonyltransferase Monomers Mycotoxins NAT Organic compounds Pathogenicity Pathogens Perfect state Phylogeny Structure-function relationships Substrate preferences Substrates
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