Novel indolotacrine hybrids as acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and molecular docking studies

A new class of indolotacrine hybrids including cyclopenta- and cyclohexa-indolotacrine derivatives was designed, synthesized, and assessed as acetylcholinesterase inhibitors (AChEIs). Some of the designed derivatives indicated a good inhibitory effect against acetylcholinesterase (AChE). Among them,...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the Iranian Chemical Society 2023-05, Vol.20 (5), p.1049-1060
Hauptverfasser:	Babaee, Saeed, Zolfigol, Mohammad Ali, Chehardoli, Gholamabbas, Faramarzi, Mohammad Ali, Mojtabavi, Somayeh, Akbarzadeh, Tahmineh, Hariri, Roshanak, Rastegari, Arezoo, Homayouni Moghadam, Farshad, Mahdavi, Mohammad, Najafi, Zahra
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Analytical Chemistry Biochemistry Cell death Chemical synthesis Chemistry Chemistry and Materials Science Hydrogen peroxide Inhibitors Inorganic Chemistry Molecular docking Organic Chemistry Original Paper Physical Chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!