Effect of carbon nanotubes on metabolism and oxidative stress response in spontaneously hypertensive rat model
Cardiovascular disease has become one of the highest mortality diseases in the world. Single walled carbon nanotubes have acute effects on the muscles and lungs of spontaneously hypertensive rats. Inhalation of multi walled carbon nanotubes can cause subchronic injury to the muscles of the rats. Spo...
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| Veröffentlicht in: | Applied nanoscience 2023-05, Vol.13 (5), p.3551-3558 |
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| creator | Zhou, Jing Dou, Dongfeng Qiu, Wenxiao Shi, Liufen |
| description | Cardiovascular disease has become one of the highest mortality diseases in the world. Single walled carbon nanotubes have acute effects on the muscles and lungs of spontaneously hypertensive rats. Inhalation of multi walled carbon nanotubes can cause subchronic injury to the muscles of the rats. Spontaneously hypertensive rats (SHR) are a good animal model of cardiovascular diseases, which exhibit similar properties to human hypertension. Therefore, in this study, the effects of carbon nanotubes on metabolism and oxidative stress in spontaneously hypertensive rats were studied. The results show that the early structural changes of cardiovascular tissue are independent of the formation of blood pressure, and there can be non-stress factors, leading to excessive structural remodeling. In group H and group L, the model of SHR rats was not passed after 7 days of administration, indicating that the two kinds of carbon nanotubes have little stimulation on SHR rats. After 30 days of administration, all the models failed, indicating that carbon nanotubes had no obvious chronic toxicity to cardiac metabolism in SHR rats. The increase of no content in SHR may be the mechanism of increased systolic blood pressure. The increase of iNOS and no in plasma may be related to the enhancement of oxidative stress after exposure to carbon nanotubes. |
| doi_str_mv | 10.1007/s13204-022-02723-z |
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Single walled carbon nanotubes have acute effects on the muscles and lungs of spontaneously hypertensive rats. Inhalation of multi walled carbon nanotubes can cause subchronic injury to the muscles of the rats. Spontaneously hypertensive rats (SHR) are a good animal model of cardiovascular diseases, which exhibit similar properties to human hypertension. Therefore, in this study, the effects of carbon nanotubes on metabolism and oxidative stress in spontaneously hypertensive rats were studied. The results show that the early structural changes of cardiovascular tissue are independent of the formation of blood pressure, and there can be non-stress factors, leading to excessive structural remodeling. In group H and group L, the model of SHR rats was not passed after 7 days of administration, indicating that the two kinds of carbon nanotubes have little stimulation on SHR rats. After 30 days of administration, all the models failed, indicating that carbon nanotubes had no obvious chronic toxicity to cardiac metabolism in SHR rats. The increase of no content in SHR may be the mechanism of increased systolic blood pressure. The increase of iNOS and no in plasma may be related to the enhancement of oxidative stress after exposure to carbon nanotubes.</description><identifier>ISSN: 2190-5509</identifier><identifier>EISSN: 2190-5517</identifier><identifier>DOI: 10.1007/s13204-022-02723-z</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Blood pressure ; Carbon ; Chemistry and Materials Science ; Hypertension ; Materials Science ; Membrane Biology ; Metabolism ; Multi wall carbon nanotubes ; Muscles ; Nanochemistry ; Nanotechnology ; Nanotechnology and Microengineering ; Original Article ; Oxidative stress ; Respiration ; Single wall carbon nanotubes ; Toxicity</subject><ispartof>Applied nanoscience, 2023-05, Vol.13 (5), p.3551-3558</ispartof><rights>Springer Nature Switzerland AG 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-f8723c21b281b1f801998f742134c5452995efe44f9c3244b72ee06b7cbab0fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13204-022-02723-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13204-022-02723-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids></links><search><creatorcontrib>Zhou, Jing</creatorcontrib><creatorcontrib>Dou, Dongfeng</creatorcontrib><creatorcontrib>Qiu, Wenxiao</creatorcontrib><creatorcontrib>Shi, Liufen</creatorcontrib><title>Effect of carbon nanotubes on metabolism and oxidative stress response in spontaneously hypertensive rat model</title><title>Applied nanoscience</title><addtitle>Appl Nanosci</addtitle><description>Cardiovascular disease has become one of the highest mortality diseases in the world. Single walled carbon nanotubes have acute effects on the muscles and lungs of spontaneously hypertensive rats. Inhalation of multi walled carbon nanotubes can cause subchronic injury to the muscles of the rats. Spontaneously hypertensive rats (SHR) are a good animal model of cardiovascular diseases, which exhibit similar properties to human hypertension. Therefore, in this study, the effects of carbon nanotubes on metabolism and oxidative stress in spontaneously hypertensive rats were studied. The results show that the early structural changes of cardiovascular tissue are independent of the formation of blood pressure, and there can be non-stress factors, leading to excessive structural remodeling. In group H and group L, the model of SHR rats was not passed after 7 days of administration, indicating that the two kinds of carbon nanotubes have little stimulation on SHR rats. After 30 days of administration, all the models failed, indicating that carbon nanotubes had no obvious chronic toxicity to cardiac metabolism in SHR rats. The increase of no content in SHR may be the mechanism of increased systolic blood pressure. The increase of iNOS and no in plasma may be related to the enhancement of oxidative stress after exposure to carbon nanotubes.</description><subject>Blood pressure</subject><subject>Carbon</subject><subject>Chemistry and Materials Science</subject><subject>Hypertension</subject><subject>Materials Science</subject><subject>Membrane Biology</subject><subject>Metabolism</subject><subject>Multi wall carbon nanotubes</subject><subject>Muscles</subject><subject>Nanochemistry</subject><subject>Nanotechnology</subject><subject>Nanotechnology and Microengineering</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Respiration</subject><subject>Single wall carbon nanotubes</subject><subject>Toxicity</subject><issn>2190-5509</issn><issn>2190-5517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9UE1LAzEQDaJgqf0DngKeV5NsttkcpdQPKHjRc0i2E92ym6xJVmx_vakrenNgvuC9N8xD6JKSa0qIuIm0ZIQXhLGcgpXF4QTNGJWkqCoqTn9nIs_RIsYdyVFxsSyrGXJra6FJ2Fvc6GC8w047n0YDEeelh6SN79rYY-222H-2W53aD8AxBYgR5zJ4FwG3Dh-npB34MXZ7_LYfICRw8YgOOuHeb6G7QGdWdxEWP32OXu7Wz6uHYvN0_7i63RQNEyQVts5vNIwaVlNDbU2olLUVnNGSNxWvmJQVWODcyqZknBvBAMjSiMZoQyyUc3Q16Q7Bv48Qk9r5Mbh8UrGaLKkgksqMYhOqCT7GAFYNoe112CtK1NFaNVmrsrXq21p1yKRyIsUMdq8Q_qT_YX0B4wZ-NA</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Zhou, Jing</creator><creator>Dou, Dongfeng</creator><creator>Qiu, Wenxiao</creator><creator>Shi, Liufen</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230501</creationdate><title>Effect of carbon nanotubes on metabolism and oxidative stress response in spontaneously hypertensive rat model</title><author>Zhou, Jing ; Dou, Dongfeng ; Qiu, Wenxiao ; Shi, Liufen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-f8723c21b281b1f801998f742134c5452995efe44f9c3244b72ee06b7cbab0fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Blood pressure</topic><topic>Carbon</topic><topic>Chemistry and Materials Science</topic><topic>Hypertension</topic><topic>Materials Science</topic><topic>Membrane Biology</topic><topic>Metabolism</topic><topic>Multi wall carbon nanotubes</topic><topic>Muscles</topic><topic>Nanochemistry</topic><topic>Nanotechnology</topic><topic>Nanotechnology and Microengineering</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Respiration</topic><topic>Single wall carbon nanotubes</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Jing</creatorcontrib><creatorcontrib>Dou, Dongfeng</creatorcontrib><creatorcontrib>Qiu, Wenxiao</creatorcontrib><creatorcontrib>Shi, Liufen</creatorcontrib><collection>CrossRef</collection><jtitle>Applied nanoscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Jing</au><au>Dou, Dongfeng</au><au>Qiu, Wenxiao</au><au>Shi, Liufen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of carbon nanotubes on metabolism and oxidative stress response in spontaneously hypertensive rat model</atitle><jtitle>Applied nanoscience</jtitle><stitle>Appl Nanosci</stitle><date>2023-05-01</date><risdate>2023</risdate><volume>13</volume><issue>5</issue><spage>3551</spage><epage>3558</epage><pages>3551-3558</pages><issn>2190-5509</issn><eissn>2190-5517</eissn><abstract>Cardiovascular disease has become one of the highest mortality diseases in the world. Single walled carbon nanotubes have acute effects on the muscles and lungs of spontaneously hypertensive rats. Inhalation of multi walled carbon nanotubes can cause subchronic injury to the muscles of the rats. Spontaneously hypertensive rats (SHR) are a good animal model of cardiovascular diseases, which exhibit similar properties to human hypertension. Therefore, in this study, the effects of carbon nanotubes on metabolism and oxidative stress in spontaneously hypertensive rats were studied. The results show that the early structural changes of cardiovascular tissue are independent of the formation of blood pressure, and there can be non-stress factors, leading to excessive structural remodeling. In group H and group L, the model of SHR rats was not passed after 7 days of administration, indicating that the two kinds of carbon nanotubes have little stimulation on SHR rats. After 30 days of administration, all the models failed, indicating that carbon nanotubes had no obvious chronic toxicity to cardiac metabolism in SHR rats. The increase of no content in SHR may be the mechanism of increased systolic blood pressure. The increase of iNOS and no in plasma may be related to the enhancement of oxidative stress after exposure to carbon nanotubes.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s13204-022-02723-z</doi><tpages>8</tpages></addata></record> |
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| subjects | Blood pressure Carbon Chemistry and Materials Science Hypertension Materials Science Membrane Biology Metabolism Multi wall carbon nanotubes Muscles Nanochemistry Nanotechnology Nanotechnology and Microengineering Original Article Oxidative stress Respiration Single wall carbon nanotubes Toxicity |
| title | Effect of carbon nanotubes on metabolism and oxidative stress response in spontaneously hypertensive rat model |
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