Chitosan Nanoparticles: The Drug Delivery System to the Anterior Segment of the Eye

The effectiveness of drug penetration into the inner tissues of the eye under local application is significantly limited by the barrier effect of the cornea and by the washout of the drug with the lacrimal fluid. To increase the bioavailability of a drug, it is proposed to include the drug in the ch...

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Veröffentlicht in:Moscow University chemistry bulletin 2023-04, Vol.78 (2), p.82-88
Hauptverfasser: Popova, E. V., Tikhomirova, V. E., Beznos, O. V., Chesnokova, N. B., Grigoriev, Y. V., Kost, O. A.
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container_end_page 88
container_issue 2
container_start_page 82
container_title Moscow University chemistry bulletin
container_volume 78
creator Popova, E. V.
Tikhomirova, V. E.
Beznos, O. V.
Chesnokova, N. B.
Grigoriev, Y. V.
Kost, O. A.
description The effectiveness of drug penetration into the inner tissues of the eye under local application is significantly limited by the barrier effect of the cornea and by the washout of the drug with the lacrimal fluid. To increase the bioavailability of a drug, it is proposed to include the drug in the chitosan particles formed by two types of chitosan: 5 kDa chitosan and 72 kDa glycol-chitosan. Chitosan particles with the loaded angiotensin-converting enzyme inhibitor enalaprilat, capable to reduce intraocular pressure, are characterized by dynamic light scattering and scanning electron microscopy. Particles formed by 5 kDa chitosan have an average hydrodynamic diameter from 85 to 125 nm and a positive ζ potential of +21 ± 3 mV, while particles formed by 72 kDa glycol-chitosan have a size from 440 to 480 nm and are characterized by a ζ potential of +10 ± 2 mV. The percentage of enalaprilat inclusion in the chitosan particles is 25% and 40%, respectively. In vivo experiments showed that the inclusion of the drug int the chitosan particles can increase the retention time of enalaprilat in the lacrimal film of rabbits.
doi_str_mv 10.3103/S0027131423020062
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subjects Bioavailability
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chitosan
Cornea
Drug delivery systems
Intraocular pressure
Nanoparticles
Original Article
Photon correlation spectroscopy
title Chitosan Nanoparticles: The Drug Delivery System to the Anterior Segment of the Eye
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