Chitosan Nanoparticles: The Drug Delivery System to the Anterior Segment of the Eye
The effectiveness of drug penetration into the inner tissues of the eye under local application is significantly limited by the barrier effect of the cornea and by the washout of the drug with the lacrimal fluid. To increase the bioavailability of a drug, it is proposed to include the drug in the ch...
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Veröffentlicht in: | Moscow University chemistry bulletin 2023-04, Vol.78 (2), p.82-88 |
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creator | Popova, E. V. Tikhomirova, V. E. Beznos, O. V. Chesnokova, N. B. Grigoriev, Y. V. Kost, O. A. |
description | The effectiveness of drug penetration into the inner tissues of the eye under local application is significantly limited by the barrier effect of the cornea and by the washout of the drug with the lacrimal fluid. To increase the bioavailability of a drug, it is proposed to include the drug in the chitosan particles formed by two types of chitosan: 5 kDa chitosan and 72 kDa glycol-chitosan. Chitosan particles with the loaded angiotensin-converting enzyme inhibitor enalaprilat, capable to reduce intraocular pressure, are characterized by dynamic light scattering and scanning electron microscopy. Particles formed by 5 kDa chitosan have an average hydrodynamic diameter from 85 to 125 nm and a positive ζ potential of +21 ± 3 mV, while particles formed by 72 kDa glycol-chitosan have a size from 440 to 480 nm and are characterized by a ζ potential of +10 ± 2 mV. The percentage of enalaprilat inclusion in the chitosan particles is 25% and 40%, respectively. In vivo experiments showed that the inclusion of the drug int the chitosan particles can increase the retention time of enalaprilat in the lacrimal film of rabbits. |
doi_str_mv | 10.3103/S0027131423020062 |
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V. ; Tikhomirova, V. E. ; Beznos, O. V. ; Chesnokova, N. B. ; Grigoriev, Y. V. ; Kost, O. A.</creator><creatorcontrib>Popova, E. V. ; Tikhomirova, V. E. ; Beznos, O. V. ; Chesnokova, N. B. ; Grigoriev, Y. V. ; Kost, O. A.</creatorcontrib><description>The effectiveness of drug penetration into the inner tissues of the eye under local application is significantly limited by the barrier effect of the cornea and by the washout of the drug with the lacrimal fluid. To increase the bioavailability of a drug, it is proposed to include the drug in the chitosan particles formed by two types of chitosan: 5 kDa chitosan and 72 kDa glycol-chitosan. Chitosan particles with the loaded angiotensin-converting enzyme inhibitor enalaprilat, capable to reduce intraocular pressure, are characterized by dynamic light scattering and scanning electron microscopy. Particles formed by 5 kDa chitosan have an average hydrodynamic diameter from 85 to 125 nm and a positive ζ potential of +21 ± 3 mV, while particles formed by 72 kDa glycol-chitosan have a size from 440 to 480 nm and are characterized by a ζ potential of +10 ± 2 mV. The percentage of enalaprilat inclusion in the chitosan particles is 25% and 40%, respectively. In vivo experiments showed that the inclusion of the drug int the chitosan particles can increase the retention time of enalaprilat in the lacrimal film of rabbits.</description><identifier>ISSN: 0027-1314</identifier><identifier>EISSN: 1935-0260</identifier><identifier>DOI: 10.3103/S0027131423020062</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Bioavailability ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Chitosan ; Cornea ; Drug delivery systems ; Intraocular pressure ; Nanoparticles ; Original Article ; Photon correlation spectroscopy</subject><ispartof>Moscow University chemistry bulletin, 2023-04, Vol.78 (2), p.82-88</ispartof><rights>Allerton Press, Inc. 2023. ISSN 0027-1314, Moscow University Chemistry Bulletin, 2023, Vol. 78, No. 2, pp. 82–88. © Allerton Press, Inc., 2023. Russian Text © The Author(s), 2023, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2023, No. 2, pp. 141–151.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-401338e7e43eb0d9d80902196e85bc9bc2c7329f756433b3c1540556fd41a6a23</citedby><cites>FETCH-LOGICAL-c316t-401338e7e43eb0d9d80902196e85bc9bc2c7329f756433b3c1540556fd41a6a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3103/S0027131423020062$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3103/S0027131423020062$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Popova, E. V.</creatorcontrib><creatorcontrib>Tikhomirova, V. E.</creatorcontrib><creatorcontrib>Beznos, O. V.</creatorcontrib><creatorcontrib>Chesnokova, N. B.</creatorcontrib><creatorcontrib>Grigoriev, Y. V.</creatorcontrib><creatorcontrib>Kost, O. A.</creatorcontrib><title>Chitosan Nanoparticles: The Drug Delivery System to the Anterior Segment of the Eye</title><title>Moscow University chemistry bulletin</title><addtitle>Moscow Univ. Chem. Bull</addtitle><description>The effectiveness of drug penetration into the inner tissues of the eye under local application is significantly limited by the barrier effect of the cornea and by the washout of the drug with the lacrimal fluid. To increase the bioavailability of a drug, it is proposed to include the drug in the chitosan particles formed by two types of chitosan: 5 kDa chitosan and 72 kDa glycol-chitosan. Chitosan particles with the loaded angiotensin-converting enzyme inhibitor enalaprilat, capable to reduce intraocular pressure, are characterized by dynamic light scattering and scanning electron microscopy. Particles formed by 5 kDa chitosan have an average hydrodynamic diameter from 85 to 125 nm and a positive ζ potential of +21 ± 3 mV, while particles formed by 72 kDa glycol-chitosan have a size from 440 to 480 nm and are characterized by a ζ potential of +10 ± 2 mV. The percentage of enalaprilat inclusion in the chitosan particles is 25% and 40%, respectively. In vivo experiments showed that the inclusion of the drug int the chitosan particles can increase the retention time of enalaprilat in the lacrimal film of rabbits.</description><subject>Bioavailability</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Chitosan</subject><subject>Cornea</subject><subject>Drug delivery systems</subject><subject>Intraocular pressure</subject><subject>Nanoparticles</subject><subject>Original Article</subject><subject>Photon correlation spectroscopy</subject><issn>0027-1314</issn><issn>1935-0260</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kEtPwzAQhC0EEuXxA7hZ4hxYe2Mn4Va15SFVcEg5R066aVO1cbFdpPx7EorEAXFaaeabWWkYuxFwhwLwPgeQiUARSwQJoOUJG4kMVQRSwykbDXY0-OfswvsNgNISkxHLJ-smWG9a_mpauzcuNNWW_ANfrIlP3WHFp7RtPsl1PO98oB0PlofeG7eBXGMdz2m1ozZwW3_rs46u2Flttp6uf-4le3-cLSbP0fzt6WUynkcVCh2iGARiSgnFSCUss2UKGUiRaUpVWWVlJasEZVYnSseIJVZCxaCUrpexMNpIvGS3x969sx8H8qHY2INr-5eFTEHFaZLIgRJHqnLWe0d1sXfNzriuEFAM2xV_tusz8pjxPduuyP02_x_6AmPJbfs</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Popova, E. V.</creator><creator>Tikhomirova, V. E.</creator><creator>Beznos, O. V.</creator><creator>Chesnokova, N. B.</creator><creator>Grigoriev, Y. V.</creator><creator>Kost, O. A.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230401</creationdate><title>Chitosan Nanoparticles: The Drug Delivery System to the Anterior Segment of the Eye</title><author>Popova, E. V. ; Tikhomirova, V. E. ; Beznos, O. V. ; Chesnokova, N. B. ; Grigoriev, Y. V. ; Kost, O. 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Particles formed by 5 kDa chitosan have an average hydrodynamic diameter from 85 to 125 nm and a positive ζ potential of +21 ± 3 mV, while particles formed by 72 kDa glycol-chitosan have a size from 440 to 480 nm and are characterized by a ζ potential of +10 ± 2 mV. The percentage of enalaprilat inclusion in the chitosan particles is 25% and 40%, respectively. In vivo experiments showed that the inclusion of the drug int the chitosan particles can increase the retention time of enalaprilat in the lacrimal film of rabbits.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.3103/S0027131423020062</doi><tpages>7</tpages></addata></record> |
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subjects | Bioavailability Chemistry Chemistry and Materials Science Chemistry/Food Science Chitosan Cornea Drug delivery systems Intraocular pressure Nanoparticles Original Article Photon correlation spectroscopy |
title | Chitosan Nanoparticles: The Drug Delivery System to the Anterior Segment of the Eye |
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