Leukocytoclastic Vasculitis Associated with Adalimumab Therapy for Crohn’s Disease
Leukocytoclastic vasculitis (LCV) is rarely associated with anti-tumor necrosis factor [TNF] α therapy. We report a 22-year-old man with new onset of a pustular rash on his bilateral upper and lower extremities while on adalimumab therapy for Crohn’s disease. Skin biopsy of the affected area showed...
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| Veröffentlicht in: | Case Reports in Gastroenterology 2023-03, Vol.17 (1), p.150-154 |
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| creator | Xu, Lankai Cathy Grandhe, Sirisha Marsano, Joseph G |
| description | Leukocytoclastic vasculitis (LCV) is rarely associated with anti-tumor necrosis factor [TNF] α therapy. We report a 22-year-old man with new onset of a pustular rash on his bilateral upper and lower extremities while on adalimumab therapy for Crohn’s disease. Skin biopsy of the affected area showed perivascular extravasation of erythrocytes, neutrophils, eosinophils and vascular damage surrounding blood vessels associated with fibrin, consistent with LCV. Patient was treated with topical steroids and subsequently transitioned to ustekinumab therapy with follow-up colonoscopy showing minimal active disease. Our report highlights the association of a unique dermatologic autoimmune manifestation with TNF-targeted therapy in a patient with Crohn’s disease. |
| doi_str_mv | 10.1159/000529045 |
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We report a 22-year-old man with new onset of a pustular rash on his bilateral upper and lower extremities while on adalimumab therapy for Crohn’s disease. Skin biopsy of the affected area showed perivascular extravasation of erythrocytes, neutrophils, eosinophils and vascular damage surrounding blood vessels associated with fibrin, consistent with LCV. Patient was treated with topical steroids and subsequently transitioned to ustekinumab therapy with follow-up colonoscopy showing minimal active disease. 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| subjects | adalimumab Autoimmune diseases Biopsy Blood vessels Care and treatment case report Case reports Colon Colonoscopy Conflicts of interest Crohns disease crohn’s disease Fibrin Inflammation Inflammatory bowel disease leukocytoclastic vasculitis Lupus Monoclonal antibodies Neutrophils Polyps Psoriasis Rectum Sacroiliitis Single Case Skin Tumor necrosis factor Tumor necrosis factor-TNF Vasculitis |
| title | Leukocytoclastic Vasculitis Associated with Adalimumab Therapy for Crohn’s Disease |
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