Disorders of Sex Development and Malignant Germ Cell Tumors
GERM CELL TUMORS 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; 2American Oncofertility Consortium, Chicago, Illinois; 3Feinberg School of Medicine, Northwestern University, Chicago, Illinois THE CASE A woman, aged 44 years, presented at the general oncolo...
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| Veröffentlicht in: | Oncology (Williston Park, N.Y.) N.Y.), 2020-10, Vol.34 (10), p.421-426 |
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| creator | Araujo-Melendez, Miguel Verduzco-Aguirre, Haydee Morales, Juan J Martinez-Benitez, Braulio Castillejos-Molina, Ricardo Fuentes, Alejandro Salama, Mahmoud Bourlon, Maria T |
| description | GERM CELL TUMORS 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; 2American Oncofertility Consortium, Chicago, Illinois; 3Feinberg School of Medicine, Northwestern University, Chicago, Illinois THE CASE A woman, aged 44 years, presented at the general oncology outpatient clinic with bloating, abdominal pain, and significant unintended weight loss. On physical examination, she was phenotypically female, with Tanner stage III-IV breast development and female genitalia with Tanner stage II pubic hair development. An ultrasound-guided core needle biopsy of the pelvic tumor was obtained and histopathological analysis reported a seminomatous germ cell tumor (GCT) (Figure 2). The GCT risk is markedly increased after puberty and reaches 33% by age 50 years.6 The principal difference in the risk level between PAIS and CAIS is explained by the rapid and total loss of germ cells in CAIS, starting at age 1 year, whereas in PAIS, patients maintain their germ cell population at about two-thirds of the normal number at puberty.15,16 The estimated GCT prevalence in patients with DSDs and different types of precursor lesions are summarized in Table 2. |
| doi_str_mv | 10.46883/ONC.2020.3410.0421 |
| format | Article |
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On physical examination, she was phenotypically female, with Tanner stage III-IV breast development and female genitalia with Tanner stage II pubic hair development. An ultrasound-guided core needle biopsy of the pelvic tumor was obtained and histopathological analysis reported a seminomatous germ cell tumor (GCT) (Figure 2). The GCT risk is markedly increased after puberty and reaches 33% by age 50 years.6 The principal difference in the risk level between PAIS and CAIS is explained by the rapid and total loss of germ cells in CAIS, starting at age 1 year, whereas in PAIS, patients maintain their germ cell population at about two-thirds of the normal number at puberty.15,16 The estimated GCT prevalence in patients with DSDs and different types of precursor lesions are summarized in Table 2.</description><identifier>ISSN: 0890-9091</identifier><identifier>DOI: 10.46883/ONC.2020.3410.0421</identifier><language>eng</language><publisher>Monmouth Junction: Intellisphere, LLC</publisher><subject>Abdomen ; Age ; Amenorrhea ; Androgens ; Biomarkers ; Biopsy ; Congenital diseases ; Dehydrogenases ; Differences of sex development ; Females ; Genotype & phenotype ; Hernia ; Hernias ; Infertility ; Males ; Medical imaging ; Medical research ; Medicine, Experimental ; Ovaries ; Patients ; Puberty ; Reproductive organs ; Sex chromosomes ; Testes ; Testicular cancer ; Tumors ; Uterus ; Young adults</subject><ispartof>Oncology (Williston Park, N.Y.), 2020-10, Vol.34 (10), p.421-426</ispartof><rights>COPYRIGHT 2020 Intellisphere, LLC</rights><rights>Copyright MultiMedia Healthcare Inc. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Araujo-Melendez, Miguel</creatorcontrib><creatorcontrib>Verduzco-Aguirre, Haydee</creatorcontrib><creatorcontrib>Morales, Juan J</creatorcontrib><creatorcontrib>Martinez-Benitez, Braulio</creatorcontrib><creatorcontrib>Castillejos-Molina, Ricardo</creatorcontrib><creatorcontrib>Fuentes, Alejandro</creatorcontrib><creatorcontrib>Salama, Mahmoud</creatorcontrib><creatorcontrib>Bourlon, Maria T</creatorcontrib><title>Disorders of Sex Development and Malignant Germ Cell Tumors</title><title>Oncology (Williston Park, N.Y.)</title><description>GERM CELL TUMORS 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; 2American Oncofertility Consortium, Chicago, Illinois; 3Feinberg School of Medicine, Northwestern University, Chicago, Illinois THE CASE A woman, aged 44 years, presented at the general oncology outpatient clinic with bloating, abdominal pain, and significant unintended weight loss. On physical examination, she was phenotypically female, with Tanner stage III-IV breast development and female genitalia with Tanner stage II pubic hair development. An ultrasound-guided core needle biopsy of the pelvic tumor was obtained and histopathological analysis reported a seminomatous germ cell tumor (GCT) (Figure 2). The GCT risk is markedly increased after puberty and reaches 33% by age 50 years.6 The principal difference in the risk level between PAIS and CAIS is explained by the rapid and total loss of germ cells in CAIS, starting at age 1 year, whereas in PAIS, patients maintain their germ cell population at about two-thirds of the normal number at puberty.15,16 The estimated GCT prevalence in patients with DSDs and different types of precursor lesions are summarized in Table 2.</description><subject>Abdomen</subject><subject>Age</subject><subject>Amenorrhea</subject><subject>Androgens</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Congenital diseases</subject><subject>Dehydrogenases</subject><subject>Differences of sex development</subject><subject>Females</subject><subject>Genotype & phenotype</subject><subject>Hernia</subject><subject>Hernias</subject><subject>Infertility</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Ovaries</subject><subject>Patients</subject><subject>Puberty</subject><subject>Reproductive organs</subject><subject>Sex chromosomes</subject><subject>Testes</subject><subject>Testicular cancer</subject><subject>Tumors</subject><subject>Uterus</subject><subject>Young adults</subject><issn>0890-9091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkUtLw0AQgHNQsD5-gZeA4C119pHNLp5Kq1Wo9mDvyzaZtCmbbN1NRP-9qRW0UOYwzPDNA74ouiYw5EJKdjd_HQ8pUBgy3veAU3ISDUAqSBQochadh7ABoEKAHET3kyo4X6APsSvjN_yMJ_iB1m1rbNrYNEX8Ymy1akxfTdHX8RitjRdd7Xy4jE5LYwNe_eaLaPH4sBg_JbP59Hk8miU5B9kmynAJjBiUmIlUImEIBmRZMJnSJVUsBUFgWaj-acGLnJpSZaiMkKIkZMkuopv92q137x2GVm9c55v-oqYSqOJpxukftTIWddWUrvUmr6uQ65HIsjSjnGU9lRyhVtigN9Y1WFZ9-4AfHuH7KLCu8qMDt_8G1mhsuw7Odm3lmnAIsj2YexeCx1JvfVUb_6UJ6B-RuhepdyL1TqTeiWTfOQWN9g</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Araujo-Melendez, Miguel</creator><creator>Verduzco-Aguirre, Haydee</creator><creator>Morales, Juan J</creator><creator>Martinez-Benitez, Braulio</creator><creator>Castillejos-Molina, Ricardo</creator><creator>Fuentes, Alejandro</creator><creator>Salama, Mahmoud</creator><creator>Bourlon, Maria T</creator><general>Intellisphere, LLC</general><general>MultiMedia Healthcare Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20201001</creationdate><title>Disorders of Sex Development and Malignant Germ Cell Tumors</title><author>Araujo-Melendez, Miguel ; 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2American Oncofertility Consortium, Chicago, Illinois; 3Feinberg School of Medicine, Northwestern University, Chicago, Illinois THE CASE A woman, aged 44 years, presented at the general oncology outpatient clinic with bloating, abdominal pain, and significant unintended weight loss. On physical examination, she was phenotypically female, with Tanner stage III-IV breast development and female genitalia with Tanner stage II pubic hair development. An ultrasound-guided core needle biopsy of the pelvic tumor was obtained and histopathological analysis reported a seminomatous germ cell tumor (GCT) (Figure 2). The GCT risk is markedly increased after puberty and reaches 33% by age 50 years.6 The principal difference in the risk level between PAIS and CAIS is explained by the rapid and total loss of germ cells in CAIS, starting at age 1 year, whereas in PAIS, patients maintain their germ cell population at about two-thirds of the normal number at puberty.15,16 The estimated GCT prevalence in patients with DSDs and different types of precursor lesions are summarized in Table 2.</abstract><cop>Monmouth Junction</cop><pub>Intellisphere, LLC</pub><doi>10.46883/ONC.2020.3410.0421</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Age Amenorrhea Androgens Biomarkers Biopsy Congenital diseases Dehydrogenases Differences of sex development Females Genotype & phenotype Hernia Hernias Infertility Males Medical imaging Medical research Medicine, Experimental Ovaries Patients Puberty Reproductive organs Sex chromosomes Testes Testicular cancer Tumors Uterus Young adults |
| title | Disorders of Sex Development and Malignant Germ Cell Tumors |
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