Refractive index as a process analytical technology to measure real time protein concentration for monitoring and control of commercial scale tangential flow filtration operations

Biological therapeutics are increasingly being formulated to high protein concentrations to decrease drug substance storage space and increase the flexibility of administration to patients. With the higher protein concentration targets comes added challenges to the downstream purification manufactur...

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Veröffentlicht in:	Journal of advanced manufacturing and processing 2023-04, Vol.5 (2), p.n/a
Hauptverfasser:	Lam, Yik, McCann, Devin, Loman, Abdullah, Smelko, John Paul, Brinkmann, Alex
Format:	Artikel
Sprache:	eng
Schlagworte:	automation and control biopharmaceutical manufacturing and processing Filtration Monoclonal antibodies Proteins Purification Refractivity Reprocessing sensors and sensing technology Technology assessment Time measurement Ultrafiltration
Online-Zugang:	Volltext
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