Synthesis and biological evaluation of chromone derivatives against triple-negative breast cancer cells

This study described the bioactivity and the structure-activity relationship (SAR) of newly synthesized chromone derivatives against triple-negative breast cancer (TNBC) MDA-MB-231 cells. Among the compounds tested, C8 exerted a growth inhibitory effect on the TNBC-derived MDA-MB-231 cells with an I...

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Veröffentlicht in:	Medicinal chemistry research 2023-05, Vol.32 (5), p.884-898
Hauptverfasser:	Islam, Rajibul, Yan, Mock Phooi, Yen, Khor Poh, Rasol, Nurulfazlina Edayah, Meng, Chan Kok, Wai, Lam Kok
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antitumor activity Apoptosis Binding sites Biochemistry Biological activity Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Breast cancer Doxorubicin Inorganic Chemistry Kinases Medicinal Chemistry Molecular docking Original Research Pharmacology/Toxicology Tyrosine
Online-Zugang:	Volltext
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