21 Inhibiting PARP-1 to restore temozolomide sensitivity and prevent resistance in glioblastoma

Adult Glioblastomas (GBMs) remain one of the least curable brain cancers despite the discovery and use of DNA alkylating agent Temozolomide (TMZ). TMZ provides a moderate survival benefit to sensitive patients whose O6-methylguanine-methyltransferase (MGMT) gene is silenced by promoter methylation....

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Canadian journal of neurological sciences 2018-06, Vol.45 (S3), p.S4-S4
Hauptverfasser:	Bering, E. A., Yuan, A. L., Cairncross, J. G., Blough, M. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	10 MAY 2018 @ 1800-1900: 11 MAY 2018 @ 1620-1720: 12 MAY 2018 @ 1010-1035 Apoptosis Autophagy Brain cancer DNA methylation DNA repair Medical prognosis Mutation POSTER VIEWING SESSIONS Radiation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!