Superoxide targeted “turn-on” fluorescence sensing enabled by a diselenide based quinoline probe and its in vitro anticancer activity in cancer cells
The first organoselenium-based quinoline probe was successfully synthesized and characterized by common spectroscopic techniques. The probe was found to be selective and sensitive for superoxide detection over other reactive oxygen species (ROS), biothiols and metal ions, bearing “turn-on” fluoresce...
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| Veröffentlicht in: | New journal of chemistry 2023-04, Vol.47 (14), p.6653-6660 |
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| container_issue | 14 |
| container_start_page | 6653 |
| container_title | New journal of chemistry |
| container_volume | 47 |
| creator | Shelar, Divyesh S. Malankar, Gauri S. Singh, Pinky R. Vaidya, Shashikant P. Pinjari, Rahul V. Manjare, Sudesh T. |
| description | The first organoselenium-based quinoline probe was successfully synthesized and characterized by common spectroscopic techniques. The probe was found to be selective and sensitive for superoxide detection over other reactive oxygen species (ROS), biothiols and metal ions, bearing “turn-on” fluorescence response with high photostability. The probe emitted strong yellowish-green fluorescence in the presence of superoxide with a 64 fold increase in fluorescence intensity. The detection limit of the probe was found to be 1.57 μM. The theoretical calculations strongly support the ICT mechanism for turn-on response. In addition, an
in vitro
cytotoxicity study revealed strong anticancer activity of the probe compared to the standard drug cisplatin in lung carcinoma (A549) and breast cancer (MCF-7) cells. The significantly high IC
50
value (65.21 μM) indicated the better biocompatibility of the probe for normal cells (MDCK) and that it will be a compelling medication for lung carcinoma cells (IC
50
= 2.14 μM) and breast cancer cells (IC
50
= 1.81 μM). |
| doi_str_mv | 10.1039/D2NJ06241K |
| format | Article |
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in vitro
cytotoxicity study revealed strong anticancer activity of the probe compared to the standard drug cisplatin in lung carcinoma (A549) and breast cancer (MCF-7) cells. The significantly high IC
50
value (65.21 μM) indicated the better biocompatibility of the probe for normal cells (MDCK) and that it will be a compelling medication for lung carcinoma cells (IC
50
= 2.14 μM) and breast cancer cells (IC
50
= 1.81 μM).</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/D2NJ06241K</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Anticancer properties ; Biocompatibility ; Breast cancer ; Fluorescence ; Lungs ; Quinoline ; Toxicity</subject><ispartof>New journal of chemistry, 2023-04, Vol.47 (14), p.6653-6660</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c259t-5088f4ed02fce2c03546729d0fc8db65f7e383c10eb733246ef0f0320c8ae7663</citedby><cites>FETCH-LOGICAL-c259t-5088f4ed02fce2c03546729d0fc8db65f7e383c10eb733246ef0f0320c8ae7663</cites><orcidid>0000-0001-5182-207X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Shelar, Divyesh S.</creatorcontrib><creatorcontrib>Malankar, Gauri S.</creatorcontrib><creatorcontrib>Singh, Pinky R.</creatorcontrib><creatorcontrib>Vaidya, Shashikant P.</creatorcontrib><creatorcontrib>Pinjari, Rahul V.</creatorcontrib><creatorcontrib>Manjare, Sudesh T.</creatorcontrib><title>Superoxide targeted “turn-on” fluorescence sensing enabled by a diselenide based quinoline probe and its in vitro anticancer activity in cancer cells</title><title>New journal of chemistry</title><description>The first organoselenium-based quinoline probe was successfully synthesized and characterized by common spectroscopic techniques. The probe was found to be selective and sensitive for superoxide detection over other reactive oxygen species (ROS), biothiols and metal ions, bearing “turn-on” fluorescence response with high photostability. The probe emitted strong yellowish-green fluorescence in the presence of superoxide with a 64 fold increase in fluorescence intensity. The detection limit of the probe was found to be 1.57 μM. The theoretical calculations strongly support the ICT mechanism for turn-on response. In addition, an
in vitro
cytotoxicity study revealed strong anticancer activity of the probe compared to the standard drug cisplatin in lung carcinoma (A549) and breast cancer (MCF-7) cells. The significantly high IC
50
value (65.21 μM) indicated the better biocompatibility of the probe for normal cells (MDCK) and that it will be a compelling medication for lung carcinoma cells (IC
50
= 2.14 μM) and breast cancer cells (IC
50
= 1.81 μM).</description><subject>Anticancer properties</subject><subject>Biocompatibility</subject><subject>Breast cancer</subject><subject>Fluorescence</subject><subject>Lungs</subject><subject>Quinoline</subject><subject>Toxicity</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpFkE1OwzAQhSMEEqWw4QSW2CEF_BcnWaLyD4IFsI4cZ1y5CnZrO4jueg0kuFxPgqsisZrRN09v5k2WHRN8RjCrzy_p0z0WlJOHnWxEmKjzmgqym3rCeY4LLvazgxBmGBNSCjLKvl6GOXj3aTpAUfopROjQevUdB29zZ9erH6T7wXkICqwCFMAGY6cIrGz7JG2XSKLOBOjBbjxaGRJdDMa63lhAc-9aQNJ2yMSAjEUfJnqXQDRKJkOPpIomweVm-IcU9H04zPa07AMc_dVx9nZ99Tq5zR-fb-4mF4-5okUd8wJXlebQYaoVUIVZyljSusNaVV0rCl0Cq5giGNqSMcoFaKwxo1hVEkoh2Dg72fqmUxcDhNjMXAqfVja0rHlBqqLiSXW6VSnvQvCgm7k379IvG4Kbzeub_9ezXx4SeuA</recordid><startdate>20230403</startdate><enddate>20230403</enddate><creator>Shelar, Divyesh S.</creator><creator>Malankar, Gauri S.</creator><creator>Singh, Pinky R.</creator><creator>Vaidya, Shashikant P.</creator><creator>Pinjari, Rahul V.</creator><creator>Manjare, Sudesh T.</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0001-5182-207X</orcidid></search><sort><creationdate>20230403</creationdate><title>Superoxide targeted “turn-on” fluorescence sensing enabled by a diselenide based quinoline probe and its in vitro anticancer activity in cancer cells</title><author>Shelar, Divyesh S. ; Malankar, Gauri S. ; Singh, Pinky R. ; Vaidya, Shashikant P. ; Pinjari, Rahul V. ; Manjare, Sudesh T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c259t-5088f4ed02fce2c03546729d0fc8db65f7e383c10eb733246ef0f0320c8ae7663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anticancer properties</topic><topic>Biocompatibility</topic><topic>Breast cancer</topic><topic>Fluorescence</topic><topic>Lungs</topic><topic>Quinoline</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shelar, Divyesh S.</creatorcontrib><creatorcontrib>Malankar, Gauri S.</creatorcontrib><creatorcontrib>Singh, Pinky R.</creatorcontrib><creatorcontrib>Vaidya, Shashikant P.</creatorcontrib><creatorcontrib>Pinjari, Rahul V.</creatorcontrib><creatorcontrib>Manjare, Sudesh T.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shelar, Divyesh S.</au><au>Malankar, Gauri S.</au><au>Singh, Pinky R.</au><au>Vaidya, Shashikant P.</au><au>Pinjari, Rahul V.</au><au>Manjare, Sudesh T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Superoxide targeted “turn-on” fluorescence sensing enabled by a diselenide based quinoline probe and its in vitro anticancer activity in cancer cells</atitle><jtitle>New journal of chemistry</jtitle><date>2023-04-03</date><risdate>2023</risdate><volume>47</volume><issue>14</issue><spage>6653</spage><epage>6660</epage><pages>6653-6660</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>The first organoselenium-based quinoline probe was successfully synthesized and characterized by common spectroscopic techniques. The probe was found to be selective and sensitive for superoxide detection over other reactive oxygen species (ROS), biothiols and metal ions, bearing “turn-on” fluorescence response with high photostability. The probe emitted strong yellowish-green fluorescence in the presence of superoxide with a 64 fold increase in fluorescence intensity. The detection limit of the probe was found to be 1.57 μM. The theoretical calculations strongly support the ICT mechanism for turn-on response. In addition, an
in vitro
cytotoxicity study revealed strong anticancer activity of the probe compared to the standard drug cisplatin in lung carcinoma (A549) and breast cancer (MCF-7) cells. The significantly high IC
50
value (65.21 μM) indicated the better biocompatibility of the probe for normal cells (MDCK) and that it will be a compelling medication for lung carcinoma cells (IC
50
= 2.14 μM) and breast cancer cells (IC
50
= 1.81 μM).</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/D2NJ06241K</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5182-207X</orcidid></addata></record> |
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| ispartof | New journal of chemistry, 2023-04, Vol.47 (14), p.6653-6660 |
| issn | 1144-0546 1369-9261 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Anticancer properties Biocompatibility Breast cancer Fluorescence Lungs Quinoline Toxicity |
| title | Superoxide targeted “turn-on” fluorescence sensing enabled by a diselenide based quinoline probe and its in vitro anticancer activity in cancer cells |
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