Case report of severe refractory inflammatory dermatoses in a young female diagnosed with hereditary alpha tryptasemia
Hereditary alpha tryptasemia (HaT), an autosomal dominant condition first described in 2014, has previously been associated with multiple dermatologic, allergic, gastrointestinal, neuropsychiatric, autonomic, and connective tissue abnormalities. We describe a pediatric patient with predominantly mix...
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| Veröffentlicht in: | Pediatric dermatology 2023-03, Vol.40 (2), p.337-340 |
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| container_title | Pediatric dermatology |
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| creator | Kranyak, Allison Shuler, Marshall Williams, Kelli W. Wine Lee, Lara |
| description | Hereditary alpha tryptasemia (HaT), an autosomal dominant condition first described in 2014, has previously been associated with multiple dermatologic, allergic, gastrointestinal, neuropsychiatric, autonomic, and connective tissue abnormalities. We describe a pediatric patient with predominantly mixed cutaneous inflammatory manifestations and atopic manifestations resistant to treatment who was found to have HaT. HaT should be considered in individuals with refractory inflammatory dermatologic disease and signs and/or symptoms concerning for mast cell activation. |
| doi_str_mv | 10.1111/pde.15160 |
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We describe a pediatric patient with predominantly mixed cutaneous inflammatory manifestations and atopic manifestations resistant to treatment who was found to have HaT. 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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | atopic dermatitis Atopy Autonomic nervous system Case reports Cell activation Child Connective tissues Dermatitis Eczema Female hereditary alpha tryptasemia Humans Hypersensitivity Hypersensitivity, Immediate mast cells Pediatrics pruritus tryptase urticaria |
| title | Case report of severe refractory inflammatory dermatoses in a young female diagnosed with hereditary alpha tryptasemia |
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