Hepatotoxicity Associated with Immune Checkpoint Inhibitors in Clinical Practice: A Study Leveraging Data from the US Food and Drug Administration's Adverse Event Reporting System

Immune checkpoint inhibitors (ICIs) are a promising option for the treatment of patients with various cancers. Emerging case reports have raised awareness on hepatotoxicity, a potentially fatal adverse event (AE) that may be associated with the use of ICIs. This study assessed the potential associat...

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Veröffentlicht in:	Clinical therapeutics 2023-02, Vol.45 (2), p.151-159
Hauptverfasser:	Yang, Hui, Wang, Haozhou, Zhou, Xiaoguang, Zhang, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Case reports Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - epidemiology Chemical and Drug Induced Liver Injury - etiology Clinical medicine Digestive System Diseases disproportionality analysis Drug-Related Side Effects and Adverse Reactions - diagnosis Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - etiology Enzymes hepatic failure Hepatitis Hepatotoxicity Humans Immune checkpoint inhibitors Immune Checkpoint Inhibitors - adverse effects Immunosuppressive agents Immunotherapy Inhibitors Liver Liver Failure Patients Pharmaceutical Preparations Pharmacovigilance real-word study Subgroups Therapy United States United States Food and Drug Administration US Food and Drug Administration Adverse Event Reporting System
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