Indium-promoted butenolide synthesis through consecutive C–C and C–O bond formations in aqueous tetrahydrofuran enabled by radicals

An indium-promoted lactonization of (indol-3-yl)-2-oxoacetaldehydes, which allows the synthesis of substituted γ-methylenebutenolides in an aqueous environment, has been accomplished. This process is in clear contrast with the established metal-mediated reactivity of unsaturated organic halides and...

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Veröffentlicht in:	Organic Chemistry Frontiers 2023-03, Vol.10 (7), p.1773-1779
Hauptverfasser:	Yanai, Hikaru, Rosa Márquez, M., Cembellín, Sara, del Campo, Teresa Martínez, Almendros, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous environments Aqueous solutions Carbonyl compounds Carbonyls Density functional theory Halides Indium Organic chemistry Synthesis Tetrahydrofuran
Online-Zugang:	Volltext
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