Review and future perspectives on the integration characteristics for equine lentivirus in the host genome
Despite over 40 years of research on the human immunodeficiency virus type 1 (HIV-1) vaccine, we still lack a considerable progress. Equine infectious anemia virus (EIAV) is a lentivirus in the Retroviridae family, akin to HIV-1 in genome structure and antigenicity. EIA is an important infectious di...
Gespeichert in:
| Veröffentlicht in: | Polish journal of veterinary sciences 2023-01, Vol.26 (1), p.163-172 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 172 |
|---|---|
| container_issue | 1 |
| container_start_page | 163 |
| container_title | Polish journal of veterinary sciences |
| container_volume | 26 |
| creator | Yu, Y-Y Xu, M-S Liang, H Wang, H-Y Yu, C-Q Liu, Q |
| description | Despite over 40 years of research on the human immunodeficiency virus type 1 (HIV-1) vaccine, we still lack a considerable progress. Equine infectious anemia virus (EIAV) is a lentivirus in the Retroviridae family, akin to HIV-1 in genome structure and antigenicity. EIA is an important infectious disease in equids, characterized by anemia, persistent infection, and repeated fevers. The EIAV attenuated vaccine in China is the only lentiviral vaccine used on a large scale. Elucidating the mechanism of waning and induction of protective immunity from this attenuated vaccine strain will provide a critical theoretical basis and reference point for vaccine research, particularly in the development of lentivirus vaccines, with far-reaching scientific value and social significance. In this paper, we summarize the information related to EIAV integration site selection, particularly for the Chinese EIAV attenuated vaccine strains on the equine genome. This may improve our mechanistic understanding of EIAV virulence reduction at the host genome level. The obtained data may help elucidate the biological characteristics of EIAV, particularly the Chinese attenuated EIAV vaccine strain, and provide valuable information regarding retroviral infections, particularly lentiviral infection and associated therapeutic vectors. |
| doi_str_mv | 10.24425/pjvs.2023.145019 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_2790104959</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2790104959</sourcerecordid><originalsourceid>FETCH-LOGICAL-p282t-db211bc46c6b7f5fcb52b0beaad332fc4d2c091fabe33bb3da57bea390bd800e3</originalsourceid><addsrcrecordid>eNo1kF1LwzAUhoMobk5_gDcS8LrzJGna5VKGU2EgiF6XJD3dUra2y8fEf2_ReXV4Oc9zDryE3DKY8zzn8mFoj2HOgYs5yyUwdUamXABkXMrynEyZBJmxshQTchVCC1AosSguyUQUqmC8KKekfcejwy-qu5o2KSaPdEAfBrTRHTHQvqNxi9R1ETdeRzdmu9Ve24jehehsoE3vKR6S65DusBs151MYjV9x24dIN9j1e7wmF43eBbw5zRn5XD19LF-y9dvz6_JxnQ18wWNWG86YsXlhC1M2srFGcgMGta6F4I3Na25BsUYbFMIYUWtZjluhwNQLABQzcv93d_D9IWGIVdsn340vK14qYJArqUbq7kQls8e6Grzba_9d_VcjfgCVv2oe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2790104959</pqid></control><display><type>article</type><title>Review and future perspectives on the integration characteristics for equine lentivirus in the host genome</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Yu, Y-Y ; Xu, M-S ; Liang, H ; Wang, H-Y ; Yu, C-Q ; Liu, Q</creator><creatorcontrib>Yu, Y-Y ; Xu, M-S ; Liang, H ; Wang, H-Y ; Yu, C-Q ; Liu, Q</creatorcontrib><description>Despite over 40 years of research on the human immunodeficiency virus type 1 (HIV-1) vaccine, we still lack a considerable progress. Equine infectious anemia virus (EIAV) is a lentivirus in the Retroviridae family, akin to HIV-1 in genome structure and antigenicity. EIA is an important infectious disease in equids, characterized by anemia, persistent infection, and repeated fevers. The EIAV attenuated vaccine in China is the only lentiviral vaccine used on a large scale. Elucidating the mechanism of waning and induction of protective immunity from this attenuated vaccine strain will provide a critical theoretical basis and reference point for vaccine research, particularly in the development of lentivirus vaccines, with far-reaching scientific value and social significance. In this paper, we summarize the information related to EIAV integration site selection, particularly for the Chinese EIAV attenuated vaccine strains on the equine genome. This may improve our mechanistic understanding of EIAV virulence reduction at the host genome level. The obtained data may help elucidate the biological characteristics of EIAV, particularly the Chinese attenuated EIAV vaccine strain, and provide valuable information regarding retroviral infections, particularly lentiviral infection and associated therapeutic vectors.</description><identifier>ISSN: 1505-1773</identifier><identifier>EISSN: 2300-2557</identifier><identifier>DOI: 10.24425/pjvs.2023.145019</identifier><identifier>PMID: 36961267</identifier><language>eng</language><publisher>Germany: Polish Academy of Sciences, Committee of Veterinary Sciences</publisher><subject>Anemia ; Animals ; Antigenicity ; Bone marrow ; Cell division ; Chromosomes ; Cytokines ; Disease ; Equine infectious anemia ; Equine Infectious Anemia - prevention & control ; Gene expression ; Gene therapy ; Genomes ; HIV ; Horse Diseases ; Horses ; Human immunodeficiency virus ; Humans ; Immune system ; Infections ; Infectious Anemia Virus, Equine - genetics ; Infectious diseases ; Lentiviruses, Equine ; Lymphatic system ; Mutagenesis ; Mutation ; Proteins ; Site selection ; Vaccines ; Vaccines, Attenuated - genetics ; Vectors ; Vectors (Biology) ; Viral infections ; Viral Vaccines ; Virulence ; Viruses</subject><ispartof>Polish journal of veterinary sciences, 2023-01, Vol.26 (1), p.163-172</ispartof><rights>Copyright© by the Polish Academy of Sciences.</rights><rights>Copyright Polish Academy of Sciences, Committee of Veterinary Sciences 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27925,27926</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36961267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Y-Y</creatorcontrib><creatorcontrib>Xu, M-S</creatorcontrib><creatorcontrib>Liang, H</creatorcontrib><creatorcontrib>Wang, H-Y</creatorcontrib><creatorcontrib>Yu, C-Q</creatorcontrib><creatorcontrib>Liu, Q</creatorcontrib><title>Review and future perspectives on the integration characteristics for equine lentivirus in the host genome</title><title>Polish journal of veterinary sciences</title><addtitle>Pol J Vet Sci</addtitle><description>Despite over 40 years of research on the human immunodeficiency virus type 1 (HIV-1) vaccine, we still lack a considerable progress. Equine infectious anemia virus (EIAV) is a lentivirus in the Retroviridae family, akin to HIV-1 in genome structure and antigenicity. EIA is an important infectious disease in equids, characterized by anemia, persistent infection, and repeated fevers. The EIAV attenuated vaccine in China is the only lentiviral vaccine used on a large scale. Elucidating the mechanism of waning and induction of protective immunity from this attenuated vaccine strain will provide a critical theoretical basis and reference point for vaccine research, particularly in the development of lentivirus vaccines, with far-reaching scientific value and social significance. In this paper, we summarize the information related to EIAV integration site selection, particularly for the Chinese EIAV attenuated vaccine strains on the equine genome. This may improve our mechanistic understanding of EIAV virulence reduction at the host genome level. The obtained data may help elucidate the biological characteristics of EIAV, particularly the Chinese attenuated EIAV vaccine strain, and provide valuable information regarding retroviral infections, particularly lentiviral infection and associated therapeutic vectors.</description><subject>Anemia</subject><subject>Animals</subject><subject>Antigenicity</subject><subject>Bone marrow</subject><subject>Cell division</subject><subject>Chromosomes</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Equine infectious anemia</subject><subject>Equine Infectious Anemia - prevention & control</subject><subject>Gene expression</subject><subject>Gene therapy</subject><subject>Genomes</subject><subject>HIV</subject><subject>Horse Diseases</subject><subject>Horses</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune system</subject><subject>Infections</subject><subject>Infectious Anemia Virus, Equine - genetics</subject><subject>Infectious diseases</subject><subject>Lentiviruses, Equine</subject><subject>Lymphatic system</subject><subject>Mutagenesis</subject><subject>Mutation</subject><subject>Proteins</subject><subject>Site selection</subject><subject>Vaccines</subject><subject>Vaccines, Attenuated - genetics</subject><subject>Vectors</subject><subject>Vectors (Biology)</subject><subject>Viral infections</subject><subject>Viral Vaccines</subject><subject>Virulence</subject><subject>Viruses</subject><issn>1505-1773</issn><issn>2300-2557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNo1kF1LwzAUhoMobk5_gDcS8LrzJGna5VKGU2EgiF6XJD3dUra2y8fEf2_ReXV4Oc9zDryE3DKY8zzn8mFoj2HOgYs5yyUwdUamXABkXMrynEyZBJmxshQTchVCC1AosSguyUQUqmC8KKekfcejwy-qu5o2KSaPdEAfBrTRHTHQvqNxi9R1ETdeRzdmu9Ve24jehehsoE3vKR6S65DusBs151MYjV9x24dIN9j1e7wmF43eBbw5zRn5XD19LF-y9dvz6_JxnQ18wWNWG86YsXlhC1M2srFGcgMGta6F4I3Na25BsUYbFMIYUWtZjluhwNQLABQzcv93d_D9IWGIVdsn340vK14qYJArqUbq7kQls8e6Grzba_9d_VcjfgCVv2oe</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Yu, Y-Y</creator><creator>Xu, M-S</creator><creator>Liang, H</creator><creator>Wang, H-Y</creator><creator>Yu, C-Q</creator><creator>Liu, Q</creator><general>Polish Academy of Sciences, Committee of Veterinary Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20230101</creationdate><title>Review and future perspectives on the integration characteristics for equine lentivirus in the host genome</title><author>Yu, Y-Y ; Xu, M-S ; Liang, H ; Wang, H-Y ; Yu, C-Q ; Liu, Q</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p282t-db211bc46c6b7f5fcb52b0beaad332fc4d2c091fabe33bb3da57bea390bd800e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anemia</topic><topic>Animals</topic><topic>Antigenicity</topic><topic>Bone marrow</topic><topic>Cell division</topic><topic>Chromosomes</topic><topic>Cytokines</topic><topic>Disease</topic><topic>Equine infectious anemia</topic><topic>Equine Infectious Anemia - prevention & control</topic><topic>Gene expression</topic><topic>Gene therapy</topic><topic>Genomes</topic><topic>HIV</topic><topic>Horse Diseases</topic><topic>Horses</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune system</topic><topic>Infections</topic><topic>Infectious Anemia Virus, Equine - genetics</topic><topic>Infectious diseases</topic><topic>Lentiviruses, Equine</topic><topic>Lymphatic system</topic><topic>Mutagenesis</topic><topic>Mutation</topic><topic>Proteins</topic><topic>Site selection</topic><topic>Vaccines</topic><topic>Vaccines, Attenuated - genetics</topic><topic>Vectors</topic><topic>Vectors (Biology)</topic><topic>Viral infections</topic><topic>Viral Vaccines</topic><topic>Virulence</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Y-Y</creatorcontrib><creatorcontrib>Xu, M-S</creatorcontrib><creatorcontrib>Liang, H</creatorcontrib><creatorcontrib>Wang, H-Y</creatorcontrib><creatorcontrib>Yu, C-Q</creatorcontrib><creatorcontrib>Liu, Q</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Polish journal of veterinary sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Y-Y</au><au>Xu, M-S</au><au>Liang, H</au><au>Wang, H-Y</au><au>Yu, C-Q</au><au>Liu, Q</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Review and future perspectives on the integration characteristics for equine lentivirus in the host genome</atitle><jtitle>Polish journal of veterinary sciences</jtitle><addtitle>Pol J Vet Sci</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>26</volume><issue>1</issue><spage>163</spage><epage>172</epage><pages>163-172</pages><issn>1505-1773</issn><eissn>2300-2557</eissn><abstract>Despite over 40 years of research on the human immunodeficiency virus type 1 (HIV-1) vaccine, we still lack a considerable progress. Equine infectious anemia virus (EIAV) is a lentivirus in the Retroviridae family, akin to HIV-1 in genome structure and antigenicity. EIA is an important infectious disease in equids, characterized by anemia, persistent infection, and repeated fevers. The EIAV attenuated vaccine in China is the only lentiviral vaccine used on a large scale. Elucidating the mechanism of waning and induction of protective immunity from this attenuated vaccine strain will provide a critical theoretical basis and reference point for vaccine research, particularly in the development of lentivirus vaccines, with far-reaching scientific value and social significance. In this paper, we summarize the information related to EIAV integration site selection, particularly for the Chinese EIAV attenuated vaccine strains on the equine genome. This may improve our mechanistic understanding of EIAV virulence reduction at the host genome level. The obtained data may help elucidate the biological characteristics of EIAV, particularly the Chinese attenuated EIAV vaccine strain, and provide valuable information regarding retroviral infections, particularly lentiviral infection and associated therapeutic vectors.</abstract><cop>Germany</cop><pub>Polish Academy of Sciences, Committee of Veterinary Sciences</pub><pmid>36961267</pmid><doi>10.24425/pjvs.2023.145019</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1505-1773 |
| ispartof | Polish journal of veterinary sciences, 2023-01, Vol.26 (1), p.163-172 |
| issn | 1505-1773 2300-2557 |
| language | eng |
| recordid | cdi_proquest_journals_2790104959 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anemia Animals Antigenicity Bone marrow Cell division Chromosomes Cytokines Disease Equine infectious anemia Equine Infectious Anemia - prevention & control Gene expression Gene therapy Genomes HIV Horse Diseases Horses Human immunodeficiency virus Humans Immune system Infections Infectious Anemia Virus, Equine - genetics Infectious diseases Lentiviruses, Equine Lymphatic system Mutagenesis Mutation Proteins Site selection Vaccines Vaccines, Attenuated - genetics Vectors Vectors (Biology) Viral infections Viral Vaccines Virulence Viruses |
| title | Review and future perspectives on the integration characteristics for equine lentivirus in the host genome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T14%3A16%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Review%20and%20future%20perspectives%20on%20the%20integration%20characteristics%20for%20equine%20lentivirus%20in%20the%20host%20genome&rft.jtitle=Polish%20journal%20of%20veterinary%20sciences&rft.au=Yu,%20Y-Y&rft.date=2023-01-01&rft.volume=26&rft.issue=1&rft.spage=163&rft.epage=172&rft.pages=163-172&rft.issn=1505-1773&rft.eissn=2300-2557&rft_id=info:doi/10.24425/pjvs.2023.145019&rft_dat=%3Cproquest_pubme%3E2790104959%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2790104959&rft_id=info:pmid/36961267&rfr_iscdi=true |