Furopyrimidines as Mackinazolinone/Isaindigotone Analogs: Synthesis, Modification, Antitumor Activity, and Molecular Docking Study
The chemical transformation of the tricyclic furo[2,3‐d]pyrimidines was performed under isosteric and scaffold‐hopping strategies focusing on the synthesis of its arylidene and imine‐containing derivatives. Naturally‐occurring alkaloids mackinazolinone and isaindigotone were as templates of target h...
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| Veröffentlicht in: | Chemistry & biodiversity 2023-03, Vol.20 (3) |
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| creator | Song, Buer Nie, Lifei Bozorov, Khurshed Niu, Chao Kuryazov, Rustamkhon Haji Akber Aisa Zhao, Jiangyu |
| description | The chemical transformation of the tricyclic furo[2,3‐d]pyrimidines was performed under isosteric and scaffold‐hopping strategies focusing on the synthesis of its arylidene and imine‐containing derivatives. Naturally‐occurring alkaloids mackinazolinone and isaindigotone were as templates of target heterocycles. Synthesized compounds evaluated for their antitumor activity on human cancer cervical HeLa, breast MCF‐7, and colon HT‐29 cell lines. Four compounds: 8c, 8e, 10b, and 10c demonstrated potency against HeLa and HT‐29 cell lines, and IC50 values were between 7.37–13.72 μM, respectively. The molecular docking results showed that compounds 8c and 10b had good binding and high matching with the target EGFR protein. |
| doi_str_mv | 10.1002/cbdv.202201059 |
| format | Article |
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Naturally‐occurring alkaloids mackinazolinone and isaindigotone were as templates of target heterocycles. Synthesized compounds evaluated for their antitumor activity on human cancer cervical HeLa, breast MCF‐7, and colon HT‐29 cell lines. Four compounds: 8c, 8e, 10b, and 10c demonstrated potency against HeLa and HT‐29 cell lines, and IC50 values were between 7.37–13.72 μM, respectively. 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| ispartof | Chemistry & biodiversity, 2023-03, Vol.20 (3) |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Anticancer properties Antitumor activity Antitumor agents Chemical synthesis Molecular docking Pyrimidines |
| title | Furopyrimidines as Mackinazolinone/Isaindigotone Analogs: Synthesis, Modification, Antitumor Activity, and Molecular Docking Study |
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