Effects of pollutant toxicity on the eyes of aquatic life monitored by visual dysfunction in zebrafish: a review
The eyes of aquatic organisms may be damaged by exposure to pollutants. Zebrafish is a common laboratory model to study ocular toxicity, combining both fish and vertebrate characteristics. The toxic effects on zebrafish eyes caused by pollutants include morphological changes and damage to the retina...
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| Veröffentlicht in: | Environmental chemistry letters 2023-04, Vol.21 (2), p.1177-1201 |
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| creator | Chen, Xiao-Fan Lin, Zhi-Cheng Qi, Zenghua Cai, Zongwei Chen, Zhi-Feng |
| description | The eyes of aquatic organisms may be damaged by exposure to pollutants. Zebrafish is a common laboratory model to study ocular toxicity, combining both fish and vertebrate characteristics. The toxic effects on zebrafish eyes caused by pollutants include morphological changes and damage to the retina at the molecular, cellular, and tissue levels; and abnormalities in the visual phototransduction and electrical signal transmission processes. Such damage induces functional disorders of vision-related behaviors. The underlying mechanisms include thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. Here, we review the ocular toxicity phenotypes and related signaling pathways induced by contaminants. We present detection methods and emerging tools for studying ocular toxicity. We also propose a model to predict the potential ocular toxicity of contaminants. |
| doi_str_mv | 10.1007/s10311-022-01531-9 |
| format | Article |
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Zebrafish is a common laboratory model to study ocular toxicity, combining both fish and vertebrate characteristics. The toxic effects on zebrafish eyes caused by pollutants include morphological changes and damage to the retina at the molecular, cellular, and tissue levels; and abnormalities in the visual phototransduction and electrical signal transmission processes. Such damage induces functional disorders of vision-related behaviors. The underlying mechanisms include thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. Here, we review the ocular toxicity phenotypes and related signaling pathways induced by contaminants. We present detection methods and emerging tools for studying ocular toxicity. We also propose a model to predict the potential ocular toxicity of contaminants.</description><identifier>ISSN: 1610-3653</identifier><identifier>EISSN: 1610-3661</identifier><identifier>DOI: 10.1007/s10311-022-01531-9</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abnormalities ; Analytical Chemistry ; Aquatic life ; Aquatic organisms ; Behavior ; Chemistry ; Contaminants ; Damage ; Danio rerio ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Eye ; Eye (anatomy) ; Eye diseases ; Fish ; Freshwater fishes ; Genes ; Geochemistry ; Glucose metabolism ; Hormones ; Laboratories ; Malformations ; Metabolism ; Morphology ; Phenotypes ; Photoreceptors ; Phototransduction ; Pollutants ; Pollution ; Pollution effects ; Pollution monitoring ; Retina ; Retinoic acid ; ReviewPaper ; Scale models ; Signal transmission ; Signaling ; Thyroid ; Toxicity ; Vertebrates ; Vision ; Visual signals ; Zebrafish</subject><ispartof>Environmental chemistry letters, 2023-04, Vol.21 (2), p.1177-1201</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. 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Zebrafish is a common laboratory model to study ocular toxicity, combining both fish and vertebrate characteristics. The toxic effects on zebrafish eyes caused by pollutants include morphological changes and damage to the retina at the molecular, cellular, and tissue levels; and abnormalities in the visual phototransduction and electrical signal transmission processes. Such damage induces functional disorders of vision-related behaviors. The underlying mechanisms include thyroid hormone signaling, retinoic acid signaling, and retinal glucose metabolism. Here, we review the ocular toxicity phenotypes and related signaling pathways induced by contaminants. We present detection methods and emerging tools for studying ocular toxicity. 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| subjects | Abnormalities Analytical Chemistry Aquatic life Aquatic organisms Behavior Chemistry Contaminants Damage Danio rerio Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Eye Eye (anatomy) Eye diseases Fish Freshwater fishes Genes Geochemistry Glucose metabolism Hormones Laboratories Malformations Metabolism Morphology Phenotypes Photoreceptors Phototransduction Pollutants Pollution Pollution effects Pollution monitoring Retina Retinoic acid ReviewPaper Scale models Signal transmission Signaling Thyroid Toxicity Vertebrates Vision Visual signals Zebrafish |
| title | Effects of pollutant toxicity on the eyes of aquatic life monitored by visual dysfunction in zebrafish: a review |
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