Relation of ischemia-modified albumin to disease manifestations and activity in Egyptian patients with Behçet’s disease
Aim of work To determine level of ischemia-modified albumin (IMA) in patients with Behçet’s disease (BD) and to assess its role in disease manifestations and activity. Patients and methods The study included 48 patients with BD and 38 matched controls. Disease activity was estimated by the BD curren...
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| Veröffentlicht in: | Egyptian Rheumatology and Rehabilitation 2019-04, Vol.46 (2), p.108-112 |
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| creator | Fouad, Nermeen A. Ahmed, Tarek I. Shaker, Olfat G. Abdelaleem, Omayma O. |
| description | Aim of work
To determine level of ischemia-modified albumin (IMA) in patients with Behçet’s disease (BD) and to assess its role in disease manifestations and activity.
Patients and methods
The study included 48 patients with BD and 38 matched controls. Disease activity was estimated by the BD current activity form. Serum IMA was measured.
Results
Mean age of the patients was 33.8±7.9 years. There were 42 males and six females, and the disease duration was 52.9±48.8 months. The serum IMA level was significantly increased in the patients with BD (50.9±12.9 U/ml) compared with the control (7.76±1.6 U/ml) (
P |
| doi_str_mv | 10.4103/err.err_66_18 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2788731252</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A583343436</galeid><sourcerecordid>A583343436</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2868-6dab3e6d9a7b4587d2a9600a7ed863b46252f429a29f76fcc6ad61bffebee2c23</originalsourceid><addsrcrecordid>eNptkd9qFDEUxoMouNReeh8QvJtt_sxkMpe11D9QEETBu5BJTnZSZpI1ySrbK1_DJ-iD-CY-iWmrroVyCIHw-845-T6EnlOybinhJ5DSuh4lhKLyEVoxMpCGM949RitKKWmooJ-fouOcLwkhtBNEEr5CVx9g1sXHgKPDPpsJFq-bJVrvPFis53G3-IBLxNZn0BnwooN3kMutKmMdKmWK_-rLHlfyfLPfFq8D3lYAQsn4my8TfgXTz2sov77_yH87PUNPnJ4zHP-5j9Cn1-cfz942F-_fvDs7vWgMk0I2wuqRg7CD7se2k71lehCE6B6sFHxsBeuYa9mg2eB64YwR2go6OgcjADOMH6EXd323KX7Z1c3VZdylUEcq1kvZc1o7HKiNnkH54GJJ2izVEnXaSc7bWqJS6weoWrb6ZmIA5-v7PcHL_wQT6LlMOc67W_Pug80daFLMOYFT2-QXnfaKEnWTsLpJ91_Ch01y5cIG0uFXDwt-AzF4rOE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2788731252</pqid></control><display><type>article</type><title>Relation of ischemia-modified albumin to disease manifestations and activity in Egyptian patients with Behçet’s disease</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><creator>Fouad, Nermeen A. ; Ahmed, Tarek I. ; Shaker, Olfat G. ; Abdelaleem, Omayma O.</creator><creatorcontrib>Fouad, Nermeen A. ; Ahmed, Tarek I. ; Shaker, Olfat G. ; Abdelaleem, Omayma O.</creatorcontrib><description>Aim of work
To determine level of ischemia-modified albumin (IMA) in patients with Behçet’s disease (BD) and to assess its role in disease manifestations and activity.
Patients and methods
The study included 48 patients with BD and 38 matched controls. Disease activity was estimated by the BD current activity form. Serum IMA was measured.
Results
Mean age of the patients was 33.8±7.9 years. There were 42 males and six females, and the disease duration was 52.9±48.8 months. The serum IMA level was significantly increased in the patients with BD (50.9±12.9 U/ml) compared with the control (7.76±1.6 U/ml) (
P
<0.001). There was a statistically significant association between IMA level and disease activity, with high mean IMA level among active cases (
P
=0.01). There was no statistically significant association between IMA level and any of other clinical characteristics in patients with BD. Sensitivity and specificity test for IMA level in detection of cases illustrated accuracy of 98.5% with sensitivity 95.8% and specificity 78.9% at cutoff value of 9.4 U/ml.
Conclusion
There is growing evidence indicating the role of oxidative stress in BD. IMA is accepted as an essential marker of oxidative stress in patients with BD. It has a potential diagnostic value for the detection of the disease. Furthermore, it correlates with the disease activity.</description><identifier>ISSN: 1110-161X</identifier><identifier>EISSN: 2090-3235</identifier><identifier>DOI: 10.4103/err.err_66_18</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Albumin ; Behcet's syndrome ; Development and progression ; Diagnosis ; Health aspects ; Ischemia ; Measurement ; Medical research ; Medicine & Public Health ; Original Article ; Oxidative stress ; Rehabilitation ; Vein & artery diseases ; Women</subject><ispartof>Egyptian Rheumatology and Rehabilitation, 2019-04, Vol.46 (2), p.108-112</ispartof><rights>Egyptian Society for Rheumatology and Rehabilitation 2019</rights><rights>COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd.</rights><rights>Egyptian Society for Rheumatology and Rehabilitation 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2868-6dab3e6d9a7b4587d2a9600a7ed863b46252f429a29f76fcc6ad61bffebee2c23</citedby><cites>FETCH-LOGICAL-c2868-6dab3e6d9a7b4587d2a9600a7ed863b46252f429a29f76fcc6ad61bffebee2c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.4103/err.err_66_18$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://doi.org/10.4103/err.err_66_18$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,27901,27902,41096,42165,51551</link.rule.ids></links><search><creatorcontrib>Fouad, Nermeen A.</creatorcontrib><creatorcontrib>Ahmed, Tarek I.</creatorcontrib><creatorcontrib>Shaker, Olfat G.</creatorcontrib><creatorcontrib>Abdelaleem, Omayma O.</creatorcontrib><title>Relation of ischemia-modified albumin to disease manifestations and activity in Egyptian patients with Behçet’s disease</title><title>Egyptian Rheumatology and Rehabilitation</title><addtitle>Egypt Rheumatol Rehabil</addtitle><description>Aim of work
To determine level of ischemia-modified albumin (IMA) in patients with Behçet’s disease (BD) and to assess its role in disease manifestations and activity.
Patients and methods
The study included 48 patients with BD and 38 matched controls. Disease activity was estimated by the BD current activity form. Serum IMA was measured.
Results
Mean age of the patients was 33.8±7.9 years. There were 42 males and six females, and the disease duration was 52.9±48.8 months. The serum IMA level was significantly increased in the patients with BD (50.9±12.9 U/ml) compared with the control (7.76±1.6 U/ml) (
P
<0.001). There was a statistically significant association between IMA level and disease activity, with high mean IMA level among active cases (
P
=0.01). There was no statistically significant association between IMA level and any of other clinical characteristics in patients with BD. Sensitivity and specificity test for IMA level in detection of cases illustrated accuracy of 98.5% with sensitivity 95.8% and specificity 78.9% at cutoff value of 9.4 U/ml.
Conclusion
There is growing evidence indicating the role of oxidative stress in BD. IMA is accepted as an essential marker of oxidative stress in patients with BD. It has a potential diagnostic value for the detection of the disease. Furthermore, it correlates with the disease activity.</description><subject>Albumin</subject><subject>Behcet's syndrome</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Health aspects</subject><subject>Ischemia</subject><subject>Measurement</subject><subject>Medical research</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Rehabilitation</subject><subject>Vein & artery diseases</subject><subject>Women</subject><issn>1110-161X</issn><issn>2090-3235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNptkd9qFDEUxoMouNReeh8QvJtt_sxkMpe11D9QEETBu5BJTnZSZpI1ySrbK1_DJ-iD-CY-iWmrroVyCIHw-845-T6EnlOybinhJ5DSuh4lhKLyEVoxMpCGM949RitKKWmooJ-fouOcLwkhtBNEEr5CVx9g1sXHgKPDPpsJFq-bJVrvPFis53G3-IBLxNZn0BnwooN3kMutKmMdKmWK_-rLHlfyfLPfFq8D3lYAQsn4my8TfgXTz2sov77_yH87PUNPnJ4zHP-5j9Cn1-cfz942F-_fvDs7vWgMk0I2wuqRg7CD7se2k71lehCE6B6sFHxsBeuYa9mg2eB64YwR2go6OgcjADOMH6EXd323KX7Z1c3VZdylUEcq1kvZc1o7HKiNnkH54GJJ2izVEnXaSc7bWqJS6weoWrb6ZmIA5-v7PcHL_wQT6LlMOc67W_Pug80daFLMOYFT2-QXnfaKEnWTsLpJ91_Ch01y5cIG0uFXDwt-AzF4rOE</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Fouad, Nermeen A.</creator><creator>Ahmed, Tarek I.</creator><creator>Shaker, Olfat G.</creator><creator>Abdelaleem, Omayma O.</creator><general>Springer Berlin Heidelberg</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20190401</creationdate><title>Relation of ischemia-modified albumin to disease manifestations and activity in Egyptian patients with Behçet’s disease</title><author>Fouad, Nermeen A. ; Ahmed, Tarek I. ; Shaker, Olfat G. ; Abdelaleem, Omayma O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2868-6dab3e6d9a7b4587d2a9600a7ed863b46252f429a29f76fcc6ad61bffebee2c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Albumin</topic><topic>Behcet's syndrome</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Health aspects</topic><topic>Ischemia</topic><topic>Measurement</topic><topic>Medical research</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Rehabilitation</topic><topic>Vein & artery diseases</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fouad, Nermeen A.</creatorcontrib><creatorcontrib>Ahmed, Tarek I.</creatorcontrib><creatorcontrib>Shaker, Olfat G.</creatorcontrib><creatorcontrib>Abdelaleem, Omayma O.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Egyptian Rheumatology and Rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fouad, Nermeen A.</au><au>Ahmed, Tarek I.</au><au>Shaker, Olfat G.</au><au>Abdelaleem, Omayma O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of ischemia-modified albumin to disease manifestations and activity in Egyptian patients with Behçet’s disease</atitle><jtitle>Egyptian Rheumatology and Rehabilitation</jtitle><stitle>Egypt Rheumatol Rehabil</stitle><date>2019-04-01</date><risdate>2019</risdate><volume>46</volume><issue>2</issue><spage>108</spage><epage>112</epage><pages>108-112</pages><issn>1110-161X</issn><eissn>2090-3235</eissn><abstract>Aim of work
To determine level of ischemia-modified albumin (IMA) in patients with Behçet’s disease (BD) and to assess its role in disease manifestations and activity.
Patients and methods
The study included 48 patients with BD and 38 matched controls. Disease activity was estimated by the BD current activity form. Serum IMA was measured.
Results
Mean age of the patients was 33.8±7.9 years. There were 42 males and six females, and the disease duration was 52.9±48.8 months. The serum IMA level was significantly increased in the patients with BD (50.9±12.9 U/ml) compared with the control (7.76±1.6 U/ml) (
P
<0.001). There was a statistically significant association between IMA level and disease activity, with high mean IMA level among active cases (
P
=0.01). There was no statistically significant association between IMA level and any of other clinical characteristics in patients with BD. Sensitivity and specificity test for IMA level in detection of cases illustrated accuracy of 98.5% with sensitivity 95.8% and specificity 78.9% at cutoff value of 9.4 U/ml.
Conclusion
There is growing evidence indicating the role of oxidative stress in BD. IMA is accepted as an essential marker of oxidative stress in patients with BD. It has a potential diagnostic value for the detection of the disease. Furthermore, it correlates with the disease activity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.4103/err.err_66_18</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Albumin Behcet's syndrome Development and progression Diagnosis Health aspects Ischemia Measurement Medical research Medicine & Public Health Original Article Oxidative stress Rehabilitation Vein & artery diseases Women |
| title | Relation of ischemia-modified albumin to disease manifestations and activity in Egyptian patients with Behçet’s disease |
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