Hemin‐Promoted Direct C−H Thiolation in the Synthesis of Diaryl Sulfides

Hemin‐Promoted Direct C−H Thiolation in the Synthesis of Diaryl Sulfides

Diaryl sulfides are a class of important synthetic chemical units. Herein, we report a new method for direct preparation of diphenyl sulfides using P‐toluenesulfonyl chloride as an effective thiophenyl radical precursor with assistance from Hemin. Various substituted anisoles and benzenesulfonyl chl...

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Veröffentlicht in:European journal of organic chemistry 2023-03, Vol.26 (12), p.n/a
Hauptverfasser: Li, Bao, Wang, Junrui, Tu, Guangliang, Ju, Guodong, Zhou, Kehan, Zhao, Yingsheng
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anisoles
benzenesulfonyl chlorides
Chlorides
C−H functionalization
diaryl sulfides
hemin
Sulfides
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container_issue 12
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container_title European journal of organic chemistry
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creator Li, Bao
Wang, Junrui
Tu, Guangliang
Ju, Guodong
Zhou, Kehan
Zhao, Yingsheng
description Diaryl sulfides are a class of important synthetic chemical units. Herein, we report a new method for direct preparation of diphenyl sulfides using P‐toluenesulfonyl chloride as an effective thiophenyl radical precursor with assistance from Hemin. Various substituted anisoles and benzenesulfonyl chlorides are well tolerated, resulting in moderate to good yields of diaryl sulfides. The potential of the proposed method is validated by good yields obtained in gram scale reactions. A new method for direct preparation of diphenyl sulfides using P‐toluenesulfonyl chloride as an effective thiophenyl radical precursor with assistance from Hemin. Various substituted anisoles and benzenesulfonyl chlorides are well tolerated. Gram scale reactions showed a satisfactory performance, demonstrating the potential synthetic application of this method.
doi_str_mv 10.1002/ejoc.202201458
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subjects anisoles
benzenesulfonyl chlorides
Chlorides
C−H functionalization
diaryl sulfides
hemin
Sulfides
title Hemin‐Promoted Direct C−H Thiolation in the Synthesis of Diaryl Sulfides
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