High efficacy of low-dose albumin infusion in the prevention of paracentesis-induced circulatory dysfunction
Background Large-volume paracentesis (LVP) is a main pillar in treating patients with tense ascites. Without plasma expanders use, paracentesis-induced circulatory dysfunction (PICD) is a common complication with decreased survival. The aim was to compare low-dose albumin (2 g/L ascitic fluid remove...
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| Veröffentlicht in: | Egyptian Liver Journal 2020-04, Vol.10 (1), p.9-8, Article 9 |
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| description | Background
Large-volume paracentesis (LVP) is a main pillar in treating patients with tense ascites. Without plasma expanders use, paracentesis-induced circulatory dysfunction (PICD) is a common complication with decreased survival. The aim was to compare low-dose albumin (2 g/L ascitic fluid removed
n
= 85) with standard-dose albumin (6 g/L ascitic fluid removed,
n
= 25) for prevention of PICD. Liver function tests, urea, creatinine, CBC, and abdominal ultrasonography were done. Plasma renin activity (PRA) was measured at baseline and on the 6th day post-LVP. The delta change (Δ) = day 6 variable minus baseline variable value. PICD was defined as increase in PRA of > 50% of the baseline value.
Results
Patients in low-dose albumin group were mainly Child B compared with Child C (85.9% vs. 52%;
p
= 0.001), underwent less paracentesis volume (9.78 ± 3.56 vs. 12.52 ± 3.6 L;
p
= 0.001), but had higher baseline PRA (859.62 ± 1151.34 vs. 165.93 ± 95.34 pg/mL;
p
= 0.001). In both groups, the PRA increased at day 6 compared with the baseline (1141.57 ± 1433.01 vs. 859.62 ± 1151.34 pg/mL;
p
= 0.01) and (192.21 ± 80.99 vs. 165.93 ± 95.34 pg/mL;
p
= 0.01) respectively. Both groups were comparable for Δ PRA (281.95 ± 851.4 vs. 26.28 ± 30.2 pg/mL;
p
= 0.102) and PRA percent increase (10.97 ± 30.77 vs. 12.57 ± 14.87;
p
= 0.844). They had comparable PICD incidence (24.7% vs. 12%;
p
= 0.27). Females were more liable for PICD occurrence than males (OR 2.91, 95% CI 1.125–7.547,
p
= 0.028) and so Child B patients than Child C (OR 8.4, 95% CI 1.072–65.767,
p
= 0.043).
Conclusion
Low-dose albumin infusion is comparable to the standard-dose albumin for the prevention of PICD. |
| doi_str_mv | 10.1186/s43066-020-0024-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_proquest_journals_2788456694</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A679595701</galeid><doaj_id>oai_doaj_org_article_419b833073e04655ad38155ffa585337</doaj_id><sourcerecordid>A679595701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4438-78d0f29767aa5041c23c259d69e660be7386e29aa545311bfa77cb6171a29baa3</originalsourceid><addsrcrecordid>eNp1UU1rFTEUHYpCS-0PcBfoemq-P5alqC0U3Og63MnHax7zJq_JjPL-vZmOWAVNFrk5Oedwc0_XvSf4hhAtP1TOsJQ9prjHmPJenHUXFBvcS0rlmz_q8-6q1j1uSxOFmbroxvu0e0IhxuTAnVCOaMw_ep9rQDAOyyFNKE1xqSmvBZqfAjqW8D1M84o0-hEKuHYNNdU-TX5xwSOXiltGmHM5IX-qcZncyn_XvY0w1nD167zsvn36-PXuvn_88vnh7vaxd5wz3SvtcaRGSQUgMCeOMkeF8dIEKfEQFNMyUNMeuWCEDBGUcoMkigA1AwC77B42X59hb48lHaCcbIZkX4BcdhbKnNwYLCdm0IxhxQLmUgjwTBMhYgShBWOqeV1vXseSn5dQZ7vPS5la-5YqrbmQ0vBX1g6aaZtYnttYDqk6eyuVEUYoTBrr5h-stn04JJenEFPD_xKQTeBKrrWE-PszBNs1ertFb1v0do3eiqahm6Y27rQL5bXh_4t-AgbSrsI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2788456694</pqid></control><display><type>article</type><title>High efficacy of low-dose albumin infusion in the prevention of paracentesis-induced circulatory dysfunction</title><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><creator>Alsebaey, Ayman ; Rewisha, Eman ; Waked, Imam</creator><creatorcontrib>Alsebaey, Ayman ; Rewisha, Eman ; Waked, Imam</creatorcontrib><description>Background
Large-volume paracentesis (LVP) is a main pillar in treating patients with tense ascites. Without plasma expanders use, paracentesis-induced circulatory dysfunction (PICD) is a common complication with decreased survival. The aim was to compare low-dose albumin (2 g/L ascitic fluid removed
n
= 85) with standard-dose albumin (6 g/L ascitic fluid removed,
n
= 25) for prevention of PICD. Liver function tests, urea, creatinine, CBC, and abdominal ultrasonography were done. Plasma renin activity (PRA) was measured at baseline and on the 6th day post-LVP. The delta change (Δ) = day 6 variable minus baseline variable value. PICD was defined as increase in PRA of > 50% of the baseline value.
Results
Patients in low-dose albumin group were mainly Child B compared with Child C (85.9% vs. 52%;
p
= 0.001), underwent less paracentesis volume (9.78 ± 3.56 vs. 12.52 ± 3.6 L;
p
= 0.001), but had higher baseline PRA (859.62 ± 1151.34 vs. 165.93 ± 95.34 pg/mL;
p
= 0.001). In both groups, the PRA increased at day 6 compared with the baseline (1141.57 ± 1433.01 vs. 859.62 ± 1151.34 pg/mL;
p
= 0.01) and (192.21 ± 80.99 vs. 165.93 ± 95.34 pg/mL;
p
= 0.01) respectively. Both groups were comparable for Δ PRA (281.95 ± 851.4 vs. 26.28 ± 30.2 pg/mL;
p
= 0.102) and PRA percent increase (10.97 ± 30.77 vs. 12.57 ± 14.87;
p
= 0.844). They had comparable PICD incidence (24.7% vs. 12%;
p
= 0.27). Females were more liable for PICD occurrence than males (OR 2.91, 95% CI 1.125–7.547,
p
= 0.028) and so Child B patients than Child C (OR 8.4, 95% CI 1.072–65.767,
p
= 0.043).
Conclusion
Low-dose albumin infusion is comparable to the standard-dose albumin for the prevention of PICD.</description><identifier>ISSN: 2090-6226</identifier><identifier>ISSN: 2090-6218</identifier><identifier>EISSN: 2090-6226</identifier><identifier>DOI: 10.1186/s43066-020-0024-5</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Albumin ; Ascites ; Blood pressure ; Creatinine ; Disease prevention ; Diuretics ; Dosage and administration ; Electrocardiography ; Ethylenediaminetetraacetic acid ; Heart rate ; Hemoglobin ; Hepatitis C ; Hepatology ; Laboratories ; Large-volume paracentesis ; Liver cirrhosis ; Medicine ; Medicine & Public Health ; Original Research Article ; Paracentesis-induced circulatory dysfunction ; Plasma ; Plasma renin activity ; Potassium ; Urea</subject><ispartof>Egyptian Liver Journal, 2020-04, Vol.10 (1), p.9-8, Article 9</ispartof><rights>The Author(s) 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-78d0f29767aa5041c23c259d69e660be7386e29aa545311bfa77cb6171a29baa3</citedby><cites>FETCH-LOGICAL-c4438-78d0f29767aa5041c23c259d69e660be7386e29aa545311bfa77cb6171a29baa3</cites><orcidid>0000-0003-3781-2312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids></links><search><creatorcontrib>Alsebaey, Ayman</creatorcontrib><creatorcontrib>Rewisha, Eman</creatorcontrib><creatorcontrib>Waked, Imam</creatorcontrib><title>High efficacy of low-dose albumin infusion in the prevention of paracentesis-induced circulatory dysfunction</title><title>Egyptian Liver Journal</title><addtitle>Egypt Liver Journal</addtitle><description>Background
Large-volume paracentesis (LVP) is a main pillar in treating patients with tense ascites. Without plasma expanders use, paracentesis-induced circulatory dysfunction (PICD) is a common complication with decreased survival. The aim was to compare low-dose albumin (2 g/L ascitic fluid removed
n
= 85) with standard-dose albumin (6 g/L ascitic fluid removed,
n
= 25) for prevention of PICD. Liver function tests, urea, creatinine, CBC, and abdominal ultrasonography were done. Plasma renin activity (PRA) was measured at baseline and on the 6th day post-LVP. The delta change (Δ) = day 6 variable minus baseline variable value. PICD was defined as increase in PRA of > 50% of the baseline value.
Results
Patients in low-dose albumin group were mainly Child B compared with Child C (85.9% vs. 52%;
p
= 0.001), underwent less paracentesis volume (9.78 ± 3.56 vs. 12.52 ± 3.6 L;
p
= 0.001), but had higher baseline PRA (859.62 ± 1151.34 vs. 165.93 ± 95.34 pg/mL;
p
= 0.001). In both groups, the PRA increased at day 6 compared with the baseline (1141.57 ± 1433.01 vs. 859.62 ± 1151.34 pg/mL;
p
= 0.01) and (192.21 ± 80.99 vs. 165.93 ± 95.34 pg/mL;
p
= 0.01) respectively. Both groups were comparable for Δ PRA (281.95 ± 851.4 vs. 26.28 ± 30.2 pg/mL;
p
= 0.102) and PRA percent increase (10.97 ± 30.77 vs. 12.57 ± 14.87;
p
= 0.844). They had comparable PICD incidence (24.7% vs. 12%;
p
= 0.27). Females were more liable for PICD occurrence than males (OR 2.91, 95% CI 1.125–7.547,
p
= 0.028) and so Child B patients than Child C (OR 8.4, 95% CI 1.072–65.767,
p
= 0.043).
Conclusion
Low-dose albumin infusion is comparable to the standard-dose albumin for the prevention of PICD.</description><subject>Albumin</subject><subject>Ascites</subject><subject>Blood pressure</subject><subject>Creatinine</subject><subject>Disease prevention</subject><subject>Diuretics</subject><subject>Dosage and administration</subject><subject>Electrocardiography</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Heart rate</subject><subject>Hemoglobin</subject><subject>Hepatitis C</subject><subject>Hepatology</subject><subject>Laboratories</subject><subject>Large-volume paracentesis</subject><subject>Liver cirrhosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Research Article</subject><subject>Paracentesis-induced circulatory dysfunction</subject><subject>Plasma</subject><subject>Plasma renin activity</subject><subject>Potassium</subject><subject>Urea</subject><issn>2090-6226</issn><issn>2090-6218</issn><issn>2090-6226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp1UU1rFTEUHYpCS-0PcBfoemq-P5alqC0U3Og63MnHax7zJq_JjPL-vZmOWAVNFrk5Oedwc0_XvSf4hhAtP1TOsJQ9prjHmPJenHUXFBvcS0rlmz_q8-6q1j1uSxOFmbroxvu0e0IhxuTAnVCOaMw_ep9rQDAOyyFNKE1xqSmvBZqfAjqW8D1M84o0-hEKuHYNNdU-TX5xwSOXiltGmHM5IX-qcZncyn_XvY0w1nD167zsvn36-PXuvn_88vnh7vaxd5wz3SvtcaRGSQUgMCeOMkeF8dIEKfEQFNMyUNMeuWCEDBGUcoMkigA1AwC77B42X59hb48lHaCcbIZkX4BcdhbKnNwYLCdm0IxhxQLmUgjwTBMhYgShBWOqeV1vXseSn5dQZ7vPS5la-5YqrbmQ0vBX1g6aaZtYnttYDqk6eyuVEUYoTBrr5h-stn04JJenEFPD_xKQTeBKrrWE-PszBNs1ertFb1v0do3eiqahm6Y27rQL5bXh_4t-AgbSrsI</recordid><startdate>20200415</startdate><enddate>20200415</enddate><creator>Alsebaey, Ayman</creator><creator>Rewisha, Eman</creator><creator>Waked, Imam</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-3781-2312</orcidid></search><sort><creationdate>20200415</creationdate><title>High efficacy of low-dose albumin infusion in the prevention of paracentesis-induced circulatory dysfunction</title><author>Alsebaey, Ayman ; Rewisha, Eman ; Waked, Imam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-78d0f29767aa5041c23c259d69e660be7386e29aa545311bfa77cb6171a29baa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Albumin</topic><topic>Ascites</topic><topic>Blood pressure</topic><topic>Creatinine</topic><topic>Disease prevention</topic><topic>Diuretics</topic><topic>Dosage and administration</topic><topic>Electrocardiography</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Heart rate</topic><topic>Hemoglobin</topic><topic>Hepatitis C</topic><topic>Hepatology</topic><topic>Laboratories</topic><topic>Large-volume paracentesis</topic><topic>Liver cirrhosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Research Article</topic><topic>Paracentesis-induced circulatory dysfunction</topic><topic>Plasma</topic><topic>Plasma renin activity</topic><topic>Potassium</topic><topic>Urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alsebaey, Ayman</creatorcontrib><creatorcontrib>Rewisha, Eman</creatorcontrib><creatorcontrib>Waked, Imam</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Liver Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alsebaey, Ayman</au><au>Rewisha, Eman</au><au>Waked, Imam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High efficacy of low-dose albumin infusion in the prevention of paracentesis-induced circulatory dysfunction</atitle><jtitle>Egyptian Liver Journal</jtitle><stitle>Egypt Liver Journal</stitle><date>2020-04-15</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>9</spage><epage>8</epage><pages>9-8</pages><artnum>9</artnum><issn>2090-6226</issn><issn>2090-6218</issn><eissn>2090-6226</eissn><abstract>Background
Large-volume paracentesis (LVP) is a main pillar in treating patients with tense ascites. Without plasma expanders use, paracentesis-induced circulatory dysfunction (PICD) is a common complication with decreased survival. The aim was to compare low-dose albumin (2 g/L ascitic fluid removed
n
= 85) with standard-dose albumin (6 g/L ascitic fluid removed,
n
= 25) for prevention of PICD. Liver function tests, urea, creatinine, CBC, and abdominal ultrasonography were done. Plasma renin activity (PRA) was measured at baseline and on the 6th day post-LVP. The delta change (Δ) = day 6 variable minus baseline variable value. PICD was defined as increase in PRA of > 50% of the baseline value.
Results
Patients in low-dose albumin group were mainly Child B compared with Child C (85.9% vs. 52%;
p
= 0.001), underwent less paracentesis volume (9.78 ± 3.56 vs. 12.52 ± 3.6 L;
p
= 0.001), but had higher baseline PRA (859.62 ± 1151.34 vs. 165.93 ± 95.34 pg/mL;
p
= 0.001). In both groups, the PRA increased at day 6 compared with the baseline (1141.57 ± 1433.01 vs. 859.62 ± 1151.34 pg/mL;
p
= 0.01) and (192.21 ± 80.99 vs. 165.93 ± 95.34 pg/mL;
p
= 0.01) respectively. Both groups were comparable for Δ PRA (281.95 ± 851.4 vs. 26.28 ± 30.2 pg/mL;
p
= 0.102) and PRA percent increase (10.97 ± 30.77 vs. 12.57 ± 14.87;
p
= 0.844). They had comparable PICD incidence (24.7% vs. 12%;
p
= 0.27). Females were more liable for PICD occurrence than males (OR 2.91, 95% CI 1.125–7.547,
p
= 0.028) and so Child B patients than Child C (OR 8.4, 95% CI 1.072–65.767,
p
= 0.043).
Conclusion
Low-dose albumin infusion is comparable to the standard-dose albumin for the prevention of PICD.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43066-020-0024-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3781-2312</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals |
| subjects | Albumin Ascites Blood pressure Creatinine Disease prevention Diuretics Dosage and administration Electrocardiography Ethylenediaminetetraacetic acid Heart rate Hemoglobin Hepatitis C Hepatology Laboratories Large-volume paracentesis Liver cirrhosis Medicine Medicine & Public Health Original Research Article Paracentesis-induced circulatory dysfunction Plasma Plasma renin activity Potassium Urea |
| title | High efficacy of low-dose albumin infusion in the prevention of paracentesis-induced circulatory dysfunction |
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