Eugenol-loaded mesoporous silica nanoparticles enhance the sensitivity of cisplatin against AGS human gastric adenocarcinoma cell line
Gastric cancer is one of the most common cancers with a high mortality rate worldwide. Eugenol possesses antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Mesoporous silica nanoparticles (MSN) have been promising carriers for drug delivery. This study aimed to investigate the...
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| Veröffentlicht in: | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2023-04, Vol.25 (4), p.57, Article 57 |
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| description | Gastric cancer is one of the most common cancers with a high mortality rate worldwide. Eugenol possesses antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Mesoporous silica nanoparticles (MSN) have been promising carriers for drug delivery. This study aimed to investigate the synergism effect of free eugenol/eugenol-MSN and cisplatin on the AGS human gastric adenocarcinoma cell line. In this study, MSN was synthesized and loaded with eugenol. Cultured AGS cells were treated with different concentrations of free eugenol/eugenol-MSN individually and in combination with cisplatin. MTT assay, scratch assay, and flow cytometry were employed to assess cell viability, migration, and apoptosis. The antioxidant properties of free eugenol/eugenol-MSN and their effect on superoxide dismutase (SOD) activity were evaluated. Real-time PCR was used to study the effect of free eugenol/eugenol-MSN on the expression of metastatic pathway genes such as MMP2, MMP9, and KRAS, and some genes involved in apoptosis including caspase 3, caspase 8, and caspase 9. A synergism effect of free eugenol/eugenol-MSN and cisplatin (CI |
| doi_str_mv | 10.1007/s11051-023-05712-7 |
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Eugenol possesses antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Mesoporous silica nanoparticles (MSN) have been promising carriers for drug delivery. This study aimed to investigate the synergism effect of free eugenol/eugenol-MSN and cisplatin on the AGS human gastric adenocarcinoma cell line. In this study, MSN was synthesized and loaded with eugenol. Cultured AGS cells were treated with different concentrations of free eugenol/eugenol-MSN individually and in combination with cisplatin. MTT assay, scratch assay, and flow cytometry were employed to assess cell viability, migration, and apoptosis. The antioxidant properties of free eugenol/eugenol-MSN and their effect on superoxide dismutase (SOD) activity were evaluated. Real-time PCR was used to study the effect of free eugenol/eugenol-MSN on the expression of metastatic pathway genes such as MMP2, MMP9, and KRAS, and some genes involved in apoptosis including caspase 3, caspase 8, and caspase 9. A synergism effect of free eugenol/eugenol-MSN and cisplatin (CI < 1) was observed. Combination therapies were significantly more effective in cell growth reduction, migration inhibition, and apoptosis induction than single treatments. Free eugenol has more potential in DPPH radical scavenging, and eugenol-MSN has more potential in increasing SOD activity. The relative expression of caspase 3, caspase 8, and caspase 9 genes in the treated cells increased compared to the control group, and the expression of MMP2, MMP9, and KRAS oncogenes decreased significantly. Eugenol loading in MSN leads to increasing the sensitivity of cisplatin against gastric cancer.</description><identifier>ISSN: 1388-0764</identifier><identifier>EISSN: 1572-896X</identifier><identifier>DOI: 10.1007/s11051-023-05712-7</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adenocarcinoma ; Anticancer properties ; Antioxidants ; Apoptosis ; Caspase-3 ; Caspase-8 ; Caspase-9 ; Cell migration ; Cell viability ; Characterization and Evaluation of Materials ; Chemistry and Materials Science ; Chemotherapy ; Cisplatin ; Drug delivery ; Eugenol ; Flow cytometry ; Gastric cancer ; Gelatinase A ; Gelatinase B ; Gene expression ; Genes ; Inflammation ; Inorganic Chemistry ; K-Ras protein ; Lasers ; Materials Science ; Metastases ; Migration inhibition ; Nanoparticles ; Nanotechnology ; Optical Devices ; Optics ; Photonics ; Physical Chemistry ; Research Paper ; Scavenging ; Sensitivity enhancement ; Silica ; Silicon dioxide ; Superoxide dismutase ; Synergism</subject><ispartof>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2023-04, Vol.25 (4), p.57, Article 57</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-359765c9766035297365b7921fea29da734dcc1cf76baf18f9d4400e1822311b3</citedby><cites>FETCH-LOGICAL-c319t-359765c9766035297365b7921fea29da734dcc1cf76baf18f9d4400e1822311b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11051-023-05712-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11051-023-05712-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Shahbazi, Shahrzad</creatorcontrib><creatorcontrib>Reiisi, Somayeh</creatorcontrib><creatorcontrib>Heidari, Razieh</creatorcontrib><creatorcontrib>Raeisi, Morteza</creatorcontrib><title>Eugenol-loaded mesoporous silica nanoparticles enhance the sensitivity of cisplatin against AGS human gastric adenocarcinoma cell line</title><title>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</title><addtitle>J Nanopart Res</addtitle><description>Gastric cancer is one of the most common cancers with a high mortality rate worldwide. Eugenol possesses antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Mesoporous silica nanoparticles (MSN) have been promising carriers for drug delivery. This study aimed to investigate the synergism effect of free eugenol/eugenol-MSN and cisplatin on the AGS human gastric adenocarcinoma cell line. In this study, MSN was synthesized and loaded with eugenol. Cultured AGS cells were treated with different concentrations of free eugenol/eugenol-MSN individually and in combination with cisplatin. MTT assay, scratch assay, and flow cytometry were employed to assess cell viability, migration, and apoptosis. The antioxidant properties of free eugenol/eugenol-MSN and their effect on superoxide dismutase (SOD) activity were evaluated. Real-time PCR was used to study the effect of free eugenol/eugenol-MSN on the expression of metastatic pathway genes such as MMP2, MMP9, and KRAS, and some genes involved in apoptosis including caspase 3, caspase 8, and caspase 9. A synergism effect of free eugenol/eugenol-MSN and cisplatin (CI < 1) was observed. Combination therapies were significantly more effective in cell growth reduction, migration inhibition, and apoptosis induction than single treatments. Free eugenol has more potential in DPPH radical scavenging, and eugenol-MSN has more potential in increasing SOD activity. The relative expression of caspase 3, caspase 8, and caspase 9 genes in the treated cells increased compared to the control group, and the expression of MMP2, MMP9, and KRAS oncogenes decreased significantly. Eugenol loading in MSN leads to increasing the sensitivity of cisplatin against gastric cancer.</description><subject>Adenocarcinoma</subject><subject>Anticancer properties</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Caspase-3</subject><subject>Caspase-8</subject><subject>Caspase-9</subject><subject>Cell migration</subject><subject>Cell viability</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Drug delivery</subject><subject>Eugenol</subject><subject>Flow cytometry</subject><subject>Gastric cancer</subject><subject>Gelatinase A</subject><subject>Gelatinase B</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Inflammation</subject><subject>Inorganic Chemistry</subject><subject>K-Ras protein</subject><subject>Lasers</subject><subject>Materials Science</subject><subject>Metastases</subject><subject>Migration inhibition</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Photonics</subject><subject>Physical Chemistry</subject><subject>Research Paper</subject><subject>Scavenging</subject><subject>Sensitivity enhancement</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Superoxide 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Res</stitle><date>2023-04-01</date><risdate>2023</risdate><volume>25</volume><issue>4</issue><spage>57</spage><pages>57-</pages><artnum>57</artnum><issn>1388-0764</issn><eissn>1572-896X</eissn><abstract>Gastric cancer is one of the most common cancers with a high mortality rate worldwide. Eugenol possesses antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Mesoporous silica nanoparticles (MSN) have been promising carriers for drug delivery. This study aimed to investigate the synergism effect of free eugenol/eugenol-MSN and cisplatin on the AGS human gastric adenocarcinoma cell line. In this study, MSN was synthesized and loaded with eugenol. Cultured AGS cells were treated with different concentrations of free eugenol/eugenol-MSN individually and in combination with cisplatin. MTT assay, scratch assay, and flow cytometry were employed to assess cell viability, migration, and apoptosis. The antioxidant properties of free eugenol/eugenol-MSN and their effect on superoxide dismutase (SOD) activity were evaluated. Real-time PCR was used to study the effect of free eugenol/eugenol-MSN on the expression of metastatic pathway genes such as MMP2, MMP9, and KRAS, and some genes involved in apoptosis including caspase 3, caspase 8, and caspase 9. A synergism effect of free eugenol/eugenol-MSN and cisplatin (CI < 1) was observed. Combination therapies were significantly more effective in cell growth reduction, migration inhibition, and apoptosis induction than single treatments. Free eugenol has more potential in DPPH radical scavenging, and eugenol-MSN has more potential in increasing SOD activity. The relative expression of caspase 3, caspase 8, and caspase 9 genes in the treated cells increased compared to the control group, and the expression of MMP2, MMP9, and KRAS oncogenes decreased significantly. Eugenol loading in MSN leads to increasing the sensitivity of cisplatin against gastric cancer.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s11051-023-05712-7</doi></addata></record> |
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| subjects | Adenocarcinoma Anticancer properties Antioxidants Apoptosis Caspase-3 Caspase-8 Caspase-9 Cell migration Cell viability Characterization and Evaluation of Materials Chemistry and Materials Science Chemotherapy Cisplatin Drug delivery Eugenol Flow cytometry Gastric cancer Gelatinase A Gelatinase B Gene expression Genes Inflammation Inorganic Chemistry K-Ras protein Lasers Materials Science Metastases Migration inhibition Nanoparticles Nanotechnology Optical Devices Optics Photonics Physical Chemistry Research Paper Scavenging Sensitivity enhancement Silica Silicon dioxide Superoxide dismutase Synergism |
| title | Eugenol-loaded mesoporous silica nanoparticles enhance the sensitivity of cisplatin against AGS human gastric adenocarcinoma cell line |
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