Children and adolescents with ADHD followed up to adulthood: a systematic review of long-term outcomes
The objective is to highlight the clinical and social outcomes among adults who suffered from Attention-Deficit Hyperactivity Disorder (ADHD) in their childhood/adolescence. PubMed, PsycINFO, and Scopus databases were searched for prospective studies published during the last 5 years addressing pati...
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Veröffentlicht in: | Acta neuropsychiatrica 2021-12, Vol.33 (6), p.283-298 |
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container_title | Acta neuropsychiatrica |
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creator | Di Lorenzo, Rosaria Balducci, Jessica Poppi, Chiara Arcolin, Elisa Cutino, Anna Ferri, Paola D'Amico, Roberto Filippini, Tommaso |
description | The objective is to highlight the clinical and social outcomes among adults who suffered from Attention-Deficit Hyperactivity Disorder (ADHD) in their childhood/adolescence. PubMed, PsycINFO, and Scopus databases were searched for prospective studies published during the last 5 years addressing patients with ADHD in childhood/adolescence followed-up to adulthood. We also included studies published before 2015 reported in other reviews with similar outcomes. Thousand four-hundred and eighty-five studies were identified, but only 39 were included for qualitative analysis and 27 for quantitative analysis. Overall, we found that ADHD persisted into adulthood with a mean rate of 43% and was mainly associated with both substance/alcohol use disorders and antisocial behavior and, less frequently, with anxiety and depressive disorders. The prevalence of persistent ADHD in adulthood reported by studies published after 2011 (55%) was higher than that reported by studies published previously from 1985 to 2011 (34%), suggesting a greater focus on ADHD in recent years. Our results highlight that ADHD can be considered not only a neurodevelopmental disorder, but also a persistent and complex condition, with detrimental consequences for quality of life in adulthood. |
doi_str_mv | 10.1017/neu.2021.23 |
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PubMed, PsycINFO, and Scopus databases were searched for prospective studies published during the last 5 years addressing patients with ADHD in childhood/adolescence followed-up to adulthood. We also included studies published before 2015 reported in other reviews with similar outcomes. Thousand four-hundred and eighty-five studies were identified, but only 39 were included for qualitative analysis and 27 for quantitative analysis. Overall, we found that ADHD persisted into adulthood with a mean rate of 43% and was mainly associated with both substance/alcohol use disorders and antisocial behavior and, less frequently, with anxiety and depressive disorders. The prevalence of persistent ADHD in adulthood reported by studies published after 2011 (55%) was higher than that reported by studies published previously from 1985 to 2011 (34%), suggesting a greater focus on ADHD in recent years. Our results highlight that ADHD can be considered not only a neurodevelopmental disorder, but also a persistent and complex condition, with detrimental consequences for quality of life in adulthood.</description><identifier>ISSN: 0924-2708</identifier><identifier>EISSN: 1601-5215</identifier><identifier>DOI: 10.1017/neu.2021.23</identifier><identifier>PMID: 34384511</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Adolescent ; Adult ; Adults ; Age ; Alcoholism ; Antisocial personality disorder ; Anxiety Disorders ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention deficit hyperactivity disorder ; Child ; Child development ; Comorbidity ; Conduct disorder ; Humans ; Hyperactivity ; Mental disorders ; Meta-analysis ; Neurodevelopmental disorders ; Prospective Studies ; Quality of Life ; Systematic review ; Teenagers</subject><ispartof>Acta neuropsychiatrica, 2021-12, Vol.33 (6), p.283-298</ispartof><rights>The Author(s), 2021. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-d93b02c99387a4176c1a1b870cd8293a673d6a7929e61b9eb4910f9529b12ffa3</citedby><cites>FETCH-LOGICAL-c317t-d93b02c99387a4176c1a1b870cd8293a673d6a7929e61b9eb4910f9529b12ffa3</cites><orcidid>0000-0003-4263-5947 ; 0000-0003-2100-0344 ; 0000-0001-9497-6837 ; 0000-0001-7761-7226 ; 0000-0002-3211-6687</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34384511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Lorenzo, Rosaria</creatorcontrib><creatorcontrib>Balducci, Jessica</creatorcontrib><creatorcontrib>Poppi, Chiara</creatorcontrib><creatorcontrib>Arcolin, Elisa</creatorcontrib><creatorcontrib>Cutino, Anna</creatorcontrib><creatorcontrib>Ferri, Paola</creatorcontrib><creatorcontrib>D'Amico, Roberto</creatorcontrib><creatorcontrib>Filippini, Tommaso</creatorcontrib><title>Children and adolescents with ADHD followed up to adulthood: a systematic review of long-term outcomes</title><title>Acta neuropsychiatrica</title><addtitle>Acta Neuropsychiatr</addtitle><description>The objective is to highlight the clinical and social outcomes among adults who suffered from Attention-Deficit Hyperactivity Disorder (ADHD) in their childhood/adolescence. 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Our results highlight that ADHD can be considered not only a neurodevelopmental disorder, but also a persistent and complex condition, with detrimental consequences for quality of life in adulthood.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Age</subject><subject>Alcoholism</subject><subject>Antisocial personality disorder</subject><subject>Anxiety Disorders</subject><subject>Attention Deficit Disorder with Hyperactivity - epidemiology</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Child</subject><subject>Child development</subject><subject>Comorbidity</subject><subject>Conduct disorder</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Mental disorders</subject><subject>Meta-analysis</subject><subject>Neurodevelopmental disorders</subject><subject>Prospective Studies</subject><subject>Quality of Life</subject><subject>Systematic review</subject><subject>Teenagers</subject><issn>0924-2708</issn><issn>1601-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNo90MFLwzAUx_EgipvTk3cJeJTOvKRtGm9jUycMvOg5pEnqOtpmJqlj_70dm57e5cPvwRehWyBTIMAfO9tPKaEwpewMjSEnkGQUsnM0JoKmCeWkGKGrEDZk0ILQSzRiKSvSDGCMqvm6boy3HVadwcq4xgZtuxjwro5rPFssF7hyTeN21uB-i6MbUN_EtXPmCSsc9iHaVsVaY29_arvDrsKN676SaH2LXR-1a224RheVaoK9Od0J-nx5_pgvk9X769t8tko0Ax4TI1hJqBaCFVylwHMNCsqCE20KKpjKOTO54oIKm0MpbJkKIJXIqCiBVpViE3R_3N16993bEOXG9b4bXkrKCy6yPAU2qIej0t6F4G0lt75uld9LIPLQVA5N5aGppAd9d9rsy9aaf_sXkf0Cd9NxnQ</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Di Lorenzo, Rosaria</creator><creator>Balducci, Jessica</creator><creator>Poppi, Chiara</creator><creator>Arcolin, Elisa</creator><creator>Cutino, Anna</creator><creator>Ferri, Paola</creator><creator>D'Amico, Roberto</creator><creator>Filippini, Tommaso</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0003-4263-5947</orcidid><orcidid>https://orcid.org/0000-0003-2100-0344</orcidid><orcidid>https://orcid.org/0000-0001-9497-6837</orcidid><orcidid>https://orcid.org/0000-0001-7761-7226</orcidid><orcidid>https://orcid.org/0000-0002-3211-6687</orcidid></search><sort><creationdate>20211201</creationdate><title>Children and adolescents with ADHD followed up to adulthood: a systematic review of long-term outcomes</title><author>Di Lorenzo, Rosaria ; 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subjects | Adolescent Adult Adults Age Alcoholism Antisocial personality disorder Anxiety Disorders Attention Deficit Disorder with Hyperactivity - epidemiology Attention deficit hyperactivity disorder Child Child development Comorbidity Conduct disorder Humans Hyperactivity Mental disorders Meta-analysis Neurodevelopmental disorders Prospective Studies Quality of Life Systematic review Teenagers |
title | Children and adolescents with ADHD followed up to adulthood: a systematic review of long-term outcomes |
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