Progress in Creation of a New Constant Medium for Hyperpolarized MRI
The MRI (Magnetic Resonance Imaging) has been used as one of the powerful tools for medical diagnoses. Its usefulness is, however, still restricted because of the low spatial resolution and long measuring time mainly due to the low NMR (Nuclear Magnetic Resonance) signals relative to the noise level...
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creator | Tanaka, Masayoshi Yosoi, Masaru Rouillé, Gérard Frossati, Georgio Fujimura, Hisako Ueda, Kunihiro de Waard, Arlette Ohta, Takeshi Fujiwara, Mamoru Makino, Seiji |
description | The MRI (Magnetic Resonance Imaging) has been used as one of the powerful tools for medical diagnoses. Its usefulness is, however, still restricted because of the low spatial resolution and long measuring time mainly due to the low NMR (Nuclear Magnetic Resonance) signals relative to the noise levels. To overcome these restrictions, we started developing a method to remarkably enlarge the NMR signals about 10 years ago. We employ a method to hyperpolarize the nuclei, where the “hyperpolarize” means to artificially generate the nuclear polarization by many orders (102~106) of magnitude higher than the ordinary NMR signals currently in use. The hyperpolarized MRI would enable us to provide images with much higher spatial resolution and shorter measuring time than ever. Several techniques for hyperpolarization have been put into practical use; the BF (Brute Force) method, PHIP (Parahydrogen Induced Polarization) method, Laser optical pumping, DNP (Dynamic Nuclear Polarization), and so on. The experimental study on the hyperpolarization of 3He by the BF method, and that of 19F in PFC (Perfluorocarbon, known as an artificial blood) by the PHIP method has gotten started. In the former method, we use an extremely low temperature realized by the Pomeranchuk cooling in combination with 3He/4He dilution refrigerator and high magnetic field. In the latter method, we use the hydrogenation of the parahydrogen in the unsaturated hydrocarbon substrate at room temperature. Very recently, we started developing a novel type of the hyperpolarized MRI named HMM (Hyperpolarized Metabolic MRI) hoping for the cancer diagnosis. |
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Its usefulness is, however, still restricted because of the low spatial resolution and long measuring time mainly due to the low NMR (Nuclear Magnetic Resonance) signals relative to the noise levels. To overcome these restrictions, we started developing a method to remarkably enlarge the NMR signals about 10 years ago. We employ a method to hyperpolarize the nuclei, where the “hyperpolarize” means to artificially generate the nuclear polarization by many orders (102~106) of magnitude higher than the ordinary NMR signals currently in use. The hyperpolarized MRI would enable us to provide images with much higher spatial resolution and shorter measuring time than ever. Several techniques for hyperpolarization have been put into practical use; the BF (Brute Force) method, PHIP (Parahydrogen Induced Polarization) method, Laser optical pumping, DNP (Dynamic Nuclear Polarization), and so on. The experimental study on the hyperpolarization of 3He by the BF method, and that of 19F in PFC (Perfluorocarbon, known as an artificial blood) by the PHIP method has gotten started. In the former method, we use an extremely low temperature realized by the Pomeranchuk cooling in combination with 3He/4He dilution refrigerator and high magnetic field. In the latter method, we use the hydrogenation of the parahydrogen in the unsaturated hydrocarbon substrate at room temperature. Very recently, we started developing a novel type of the hyperpolarized MRI named HMM (Hyperpolarized Metabolic MRI) hoping for the cancer diagnosis.</description><identifier>ISSN: 1013-9826</identifier><identifier>ISSN: 1662-9795</identifier><identifier>EISSN: 1662-9795</identifier><identifier>DOI: 10.4028/www.scientific.net/KEM.843.52</identifier><language>eng</language><publisher>Zurich: Trans Tech Publications Ltd</publisher><subject>Acids ; Cancer ; Contrast agents ; Cooling ; Dilution ; Feasibility studies ; Hydrocarbons ; Hydrogenation ; Induced polarization ; Laser pumping ; Low temperature ; Magnetic fields ; Magnetic resonance imaging ; Medical diagnosis ; Metabolism ; NMR ; Noise levels ; Nuclear magnetic resonance ; Optical pumping ; Perfluorocarbons ; Physics ; Radiation ; Room temperature ; Spatial resolution ; Substrates ; Time measurement</subject><ispartof>Key engineering materials, 2020-05, Vol.843, p.52-57</ispartof><rights>2020 Trans Tech Publications Ltd</rights><rights>Copyright Trans Tech Publications Ltd. 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The experimental study on the hyperpolarization of 3He by the BF method, and that of 19F in PFC (Perfluorocarbon, known as an artificial blood) by the PHIP method has gotten started. In the former method, we use an extremely low temperature realized by the Pomeranchuk cooling in combination with 3He/4He dilution refrigerator and high magnetic field. In the latter method, we use the hydrogenation of the parahydrogen in the unsaturated hydrocarbon substrate at room temperature. Very recently, we started developing a novel type of the hyperpolarized MRI named HMM (Hyperpolarized Metabolic MRI) hoping for the cancer diagnosis.</description><subject>Acids</subject><subject>Cancer</subject><subject>Contrast agents</subject><subject>Cooling</subject><subject>Dilution</subject><subject>Feasibility studies</subject><subject>Hydrocarbons</subject><subject>Hydrogenation</subject><subject>Induced polarization</subject><subject>Laser pumping</subject><subject>Low temperature</subject><subject>Magnetic fields</subject><subject>Magnetic resonance imaging</subject><subject>Medical diagnosis</subject><subject>Metabolism</subject><subject>NMR</subject><subject>Noise levels</subject><subject>Nuclear magnetic resonance</subject><subject>Optical pumping</subject><subject>Perfluorocarbons</subject><subject>Physics</subject><subject>Radiation</subject><subject>Room temperature</subject><subject>Spatial resolution</subject><subject>Substrates</subject><subject>Time measurement</subject><issn>1013-9826</issn><issn>1662-9795</issn><issn>1662-9795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkE1LwzAYx4MoOKffISAe2yVp3noQkTndcFMRPYesTTRja2rSUeanNzJhV0_P__B_4fkBcIVRThGRo77v81g503TOuipvTDd6nCxySYuckSMwwJyTrBQlO04a4SIrJeGn4CzGFUIFlpgNwN1L8B_BxAhdA8fB6M75BnoLNXwyPRz7Jna66eDC1G67gdYHON21JrR-rYP7NjVcvM7OwYnV62gu_u4QvN9P3sbTbP78MBvfzrOKIEkyliYpRQgzxq1ZyoIWGpcCcYLrkooac4Sqmotal0ILUVOsqRWEWWPwklW0GILLfW8b_NfWxE6t_DY0aVIRITkTGEmWXNd7VxV8jMFY1Qa30WGnMFK_4FQCpw7gVAKnEjiVwClGUv5mn--CTt-b6vMw87-GH3HcfSg</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Tanaka, Masayoshi</creator><creator>Yosoi, Masaru</creator><creator>Rouillé, Gérard</creator><creator>Frossati, Georgio</creator><creator>Fujimura, Hisako</creator><creator>Ueda, Kunihiro</creator><creator>de Waard, Arlette</creator><creator>Ohta, Takeshi</creator><creator>Fujiwara, Mamoru</creator><creator>Makino, Seiji</creator><general>Trans Tech Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope></search><sort><creationdate>20200501</creationdate><title>Progress in Creation of a New Constant Medium for Hyperpolarized MRI</title><author>Tanaka, Masayoshi ; 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The experimental study on the hyperpolarization of 3He by the BF method, and that of 19F in PFC (Perfluorocarbon, known as an artificial blood) by the PHIP method has gotten started. In the former method, we use an extremely low temperature realized by the Pomeranchuk cooling in combination with 3He/4He dilution refrigerator and high magnetic field. In the latter method, we use the hydrogenation of the parahydrogen in the unsaturated hydrocarbon substrate at room temperature. Very recently, we started developing a novel type of the hyperpolarized MRI named HMM (Hyperpolarized Metabolic MRI) hoping for the cancer diagnosis.</abstract><cop>Zurich</cop><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/KEM.843.52</doi><tpages>6</tpages></addata></record> |
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subjects | Acids Cancer Contrast agents Cooling Dilution Feasibility studies Hydrocarbons Hydrogenation Induced polarization Laser pumping Low temperature Magnetic fields Magnetic resonance imaging Medical diagnosis Metabolism NMR Noise levels Nuclear magnetic resonance Optical pumping Perfluorocarbons Physics Radiation Room temperature Spatial resolution Substrates Time measurement |
title | Progress in Creation of a New Constant Medium for Hyperpolarized MRI |
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