Effects of mutations at thestambh A locus ofDrosophila melanogaster
We report novel findings on the cytogenetic location, functional complexity and maternal and germline roles of thestambh A locus ofDrosophila melanogaster. stmA is localized to polytene bands 44D1.2 on 2R.stmA mutations are of two types: temperature-sensitive (ts) adult and larval paralytic or uncon...
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| Veröffentlicht in: | Journal of genetics 2001-08, Vol.80 (2), p.83-95 |
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| creator | Kumar, M. Joseph, Minu Chandrashekaran, Shanti |
| description | We report novel findings on the cytogenetic location, functional complexity and maternal and germline roles of thestambh A locus ofDrosophila melanogaster. stmA is localized to polytene bands 44D1.2 on 2R.stmA mutations are of two types: temperature-sensitive (ts) adult and larval paralytic or unconditional embryonic or larval lethal. Twelve alleles reported in this study fall into two intragenic complementing groups suggesting thatstmA is a complex locus with more than one functional domain. Some unconditional embryonic lethal alleles show a 'neurogenic' phenotype of cuticle loss accompanied by neural hypertrophy. It is shown that embryos of ts paralytic alleles also show mild neural hypertrophy at permissive temperatures while short exposure to heat induces severe cuticle loss in these embryos.stmA exerts a maternal influence over heat-induced cuticle loss. Unconditional embryonic lethal alleles ofstmA are also germline lethal.[PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1007/BF02728334 |
| format | Article |
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Twelve alleles reported in this study fall into two intragenic complementing groups suggesting thatstmA is a complex locus with more than one functional domain. Some unconditional embryonic lethal alleles show a 'neurogenic' phenotype of cuticle loss accompanied by neural hypertrophy. It is shown that embryos of ts paralytic alleles also show mild neural hypertrophy at permissive temperatures while short exposure to heat induces severe cuticle loss in these embryos.stmA exerts a maternal influence over heat-induced cuticle loss. Unconditional embryonic lethal alleles ofstmA are also germline lethal.[PUBLICATION ABSTRACT]</description><identifier>ISSN: 0022-1333</identifier><identifier>EISSN: 0973-7731</identifier><identifier>DOI: 10.1007/BF02728334</identifier><language>eng</language><publisher>London: Springer Nature B.V</publisher><subject>Alleles ; Cytogenetics ; Drosophila melanogaster ; Embryos ; Epicuticle ; Gene loci ; Genomics ; Hypertrophy ; Insects ; Mutation ; Phenotypes ; Polytene</subject><ispartof>Journal of genetics, 2001-08, Vol.80 (2), p.83-95</ispartof><rights>Indian Academy of Sciences 2001</rights><rights>Indian Academy of Sciences 2001.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1312-30fd760088d17dfc910024f392be33caede5117b69127b1d6f3ead85c21838e13</citedby><cites>FETCH-LOGICAL-c1312-30fd760088d17dfc910024f392be33caede5117b69127b1d6f3ead85c21838e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Kumar, M.</creatorcontrib><creatorcontrib>Joseph, Minu</creatorcontrib><creatorcontrib>Chandrashekaran, Shanti</creatorcontrib><title>Effects of mutations at thestambh A locus ofDrosophila melanogaster</title><title>Journal of genetics</title><description>We report novel findings on the cytogenetic location, functional complexity and maternal and germline roles of thestambh A locus ofDrosophila melanogaster. stmA is localized to polytene bands 44D1.2 on 2R.stmA mutations are of two types: temperature-sensitive (ts) adult and larval paralytic or unconditional embryonic or larval lethal. Twelve alleles reported in this study fall into two intragenic complementing groups suggesting thatstmA is a complex locus with more than one functional domain. Some unconditional embryonic lethal alleles show a 'neurogenic' phenotype of cuticle loss accompanied by neural hypertrophy. It is shown that embryos of ts paralytic alleles also show mild neural hypertrophy at permissive temperatures while short exposure to heat induces severe cuticle loss in these embryos.stmA exerts a maternal influence over heat-induced cuticle loss. Unconditional embryonic lethal alleles ofstmA are also germline lethal.[PUBLICATION ABSTRACT]</description><subject>Alleles</subject><subject>Cytogenetics</subject><subject>Drosophila melanogaster</subject><subject>Embryos</subject><subject>Epicuticle</subject><subject>Gene loci</subject><subject>Genomics</subject><subject>Hypertrophy</subject><subject>Insects</subject><subject>Mutation</subject><subject>Phenotypes</subject><subject>Polytene</subject><issn>0022-1333</issn><issn>0973-7731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kDFPwzAQhS0EEqWw8Ass2JACPl8SO2MpLSBVYoE5chybtErqYjsD_x5HRWJiujvpu7v3HiHXwO6BMfHwuGZccImYn5AZqwRmQiCcpp5xngEinpOLEHbTKBifkeXKWqNjoM7SYYwqbt0-UBVp7EyIamg6uqC90-NEPHkX3KHb9ooOpld796lCNP6SnFnVB3P1W-fkY716X75km7fn1-Vik2lA4Bky24qSMSlbEK3VVVLMc4sVbwyiVqY1BYBoygq4aKAtLRrVykJzkCgN4JzcHu8evPsak7x650a_Ty9rLmRZFDxtJurmPwoqwZHlBSbo7gjpZCl4Y-uD3w7Kf9fA6inJ-i9J_AGOimNe</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Kumar, M.</creator><creator>Joseph, Minu</creator><creator>Chandrashekaran, Shanti</creator><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope></search><sort><creationdate>20010801</creationdate><title>Effects of mutations at thestambh A locus ofDrosophila melanogaster</title><author>Kumar, M. ; 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Twelve alleles reported in this study fall into two intragenic complementing groups suggesting thatstmA is a complex locus with more than one functional domain. Some unconditional embryonic lethal alleles show a 'neurogenic' phenotype of cuticle loss accompanied by neural hypertrophy. It is shown that embryos of ts paralytic alleles also show mild neural hypertrophy at permissive temperatures while short exposure to heat induces severe cuticle loss in these embryos.stmA exerts a maternal influence over heat-induced cuticle loss. Unconditional embryonic lethal alleles ofstmA are also germline lethal.[PUBLICATION ABSTRACT]</abstract><cop>London</cop><pub>Springer Nature B.V</pub><doi>10.1007/BF02728334</doi><tpages>13</tpages></addata></record> |
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| source | SpringerNature Journals; Indian Academy of Sciences; EZB-FREE-00999 freely available EZB journals |
| subjects | Alleles Cytogenetics Drosophila melanogaster Embryos Epicuticle Gene loci Genomics Hypertrophy Insects Mutation Phenotypes Polytene |
| title | Effects of mutations at thestambh A locus ofDrosophila melanogaster |
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