Calcium equally increases the internal calcium recirculation fraction before and after beta-blockade in canine left ventricles
We studied whether intracoronary Ca administration after beta-blockade would increase the internal Ca recirculation fraction (RF) analogously to the Ca administration before beta-blockade. This was performed in excised cross-circulated canine hearts. We analyzed the exponential decay component of th...
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| Veröffentlicht in: | Heart and vessels 1997-01, Vol.12 (6), p.280-286 |
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| creator | Hosogi, S Araki, J Syuu, Y Suzuki, S Mohri, S Mikane, T Matsubara, H Ohe, T Hirakawa, M Suga, H |
| description | We studied whether intracoronary Ca administration after beta-blockade would increase the internal Ca recirculation fraction (RF) analogously to the Ca administration before beta-blockade. This was performed in excised cross-circulated canine hearts. We analyzed the exponential decay component of the postextrasystolic potentiation (PESP) following a spontaneous extrasystole. All the PESPs decayed in alternans with atrial pacing at a constant rate. We obtained the time constant (tau(e)) of the monoexponential decay component of the alternans PESP. An increment of intracoronary Ca by 1.5 mmol/l enhanced the left ventricular contractility index Emax (end-systolic maximum elastance) by 2.5 times before and after beta-blockade with propranolol. The intracoronary Ca after beta-blockade slightly but significantly increased tau(e), and hence increased RF calculated from tau(e) by RF = exp(-1/tau(e)). This was analogous to the slightly increased tau(e) and RF with Ca before beta-blockade. We speculate that the myocardial cyclic AMP-dependent phosphorylation level would not significantly alter the effect of intracoronarily administered Ca on myocardial Ca handling, in terms of tau(e) and RF. |
| doi_str_mv | 10.1007/BF02766804 |
| format | Article |
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This was performed in excised cross-circulated canine hearts. We analyzed the exponential decay component of the postextrasystolic potentiation (PESP) following a spontaneous extrasystole. All the PESPs decayed in alternans with atrial pacing at a constant rate. We obtained the time constant (tau(e)) of the monoexponential decay component of the alternans PESP. An increment of intracoronary Ca by 1.5 mmol/l enhanced the left ventricular contractility index Emax (end-systolic maximum elastance) by 2.5 times before and after beta-blockade with propranolol. The intracoronary Ca after beta-blockade slightly but significantly increased tau(e), and hence increased RF calculated from tau(e) by RF = exp(-1/tau(e)). This was analogous to the slightly increased tau(e) and RF with Ca before beta-blockade. We speculate that the myocardial cyclic AMP-dependent phosphorylation level would not significantly alter the effect of intracoronarily administered Ca on myocardial Ca handling, in terms of tau(e) and RF.</description><identifier>ISSN: 0910-8327</identifier><identifier>EISSN: 1615-2573</identifier><identifier>DOI: 10.1007/BF02766804</identifier><identifier>PMID: 9860195</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Adenosine Monophosphate - metabolism ; Adrenergic beta-Antagonists - pharmacology ; Alternan ; Animals ; Arrhythmias, Cardiac - drug therapy ; Arrhythmias, Cardiac - metabolism ; Arrhythmias, Cardiac - physiopathology ; Calcium ; Calcium - administration & dosage ; Calcium - pharmacokinetics ; Calcium Channels - drug effects ; Calcium Channels - metabolism ; Contractility ; Coronary Vessels ; Cyclic AMP ; Decay ; Disease Models, Animal ; Dogs ; Electrocardiography - drug effects ; Heart ; Heart Ventricles - drug effects ; Heart Ventricles - metabolism ; Heart Ventricles - physiopathology ; Injections, Intra-Arterial ; Myocardial Contraction - drug effects ; Phosphorylation ; Propranolol ; Propranolol - pharmacology ; Time constant ; Ventricle</subject><ispartof>Heart and vessels, 1997-01, Vol.12 (6), p.280-286</ispartof><rights>Springer-Verlag 1997.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c312t-c347f2c32422c2299ad51331d74d69cd636c60dc930c56db51cbfcd2024f9fd83</citedby><cites>FETCH-LOGICAL-c312t-c347f2c32422c2299ad51331d74d69cd636c60dc930c56db51cbfcd2024f9fd83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9860195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hosogi, S</creatorcontrib><creatorcontrib>Araki, J</creatorcontrib><creatorcontrib>Syuu, Y</creatorcontrib><creatorcontrib>Suzuki, S</creatorcontrib><creatorcontrib>Mohri, S</creatorcontrib><creatorcontrib>Mikane, T</creatorcontrib><creatorcontrib>Matsubara, H</creatorcontrib><creatorcontrib>Ohe, T</creatorcontrib><creatorcontrib>Hirakawa, M</creatorcontrib><creatorcontrib>Suga, H</creatorcontrib><title>Calcium equally increases the internal calcium recirculation fraction before and after beta-blockade in canine left ventricles</title><title>Heart and vessels</title><addtitle>Heart Vessels</addtitle><description>We studied whether intracoronary Ca administration after beta-blockade would increase the internal Ca recirculation fraction (RF) analogously to the Ca administration before beta-blockade. This was performed in excised cross-circulated canine hearts. We analyzed the exponential decay component of the postextrasystolic potentiation (PESP) following a spontaneous extrasystole. All the PESPs decayed in alternans with atrial pacing at a constant rate. We obtained the time constant (tau(e)) of the monoexponential decay component of the alternans PESP. An increment of intracoronary Ca by 1.5 mmol/l enhanced the left ventricular contractility index Emax (end-systolic maximum elastance) by 2.5 times before and after beta-blockade with propranolol. The intracoronary Ca after beta-blockade slightly but significantly increased tau(e), and hence increased RF calculated from tau(e) by RF = exp(-1/tau(e)). This was analogous to the slightly increased tau(e) and RF with Ca before beta-blockade. We speculate that the myocardial cyclic AMP-dependent phosphorylation level would not significantly alter the effect of intracoronarily administered Ca on myocardial Ca handling, in terms of tau(e) and RF.</description><subject>Adenosine Monophosphate - metabolism</subject><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Alternan</subject><subject>Animals</subject><subject>Arrhythmias, Cardiac - drug therapy</subject><subject>Arrhythmias, Cardiac - metabolism</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Calcium</subject><subject>Calcium - administration & dosage</subject><subject>Calcium - pharmacokinetics</subject><subject>Calcium Channels - drug effects</subject><subject>Calcium Channels - metabolism</subject><subject>Contractility</subject><subject>Coronary Vessels</subject><subject>Cyclic AMP</subject><subject>Decay</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Electrocardiography - drug effects</subject><subject>Heart</subject><subject>Heart Ventricles - drug effects</subject><subject>Heart Ventricles - metabolism</subject><subject>Heart Ventricles - physiopathology</subject><subject>Injections, Intra-Arterial</subject><subject>Myocardial Contraction - drug effects</subject><subject>Phosphorylation</subject><subject>Propranolol</subject><subject>Propranolol - pharmacology</subject><subject>Time constant</subject><subject>Ventricle</subject><issn>0910-8327</issn><issn>1615-2573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9LwzAUx4Moc04v3oWAN6GaH03aHHU4FQZe9FzSlwQ7s3ZLUmEX_3Y7V_SSl_f4vA-8L0KXlNxSQoq7hwVhhZQlyY_QlEoqMiYKfoymRFGSlZwVp-gsxhUhVCiqJmiiSkmoElP0Pdcemn6N7bbX3u9w00KwOtqI04cdumRDqz2GEQsWmgC916npWuyCht9PbV0XLNatwdoNK8Mg6az2HXxqs9cMgrZpLfbWJfxl2xQa8DaeoxOnfbQXY52h98Xj2_w5W74-vczvlxlwytLw5oVjwFnOGDCmlDaCck5NkRupwEguQRIDihMQ0tSCQu3AMMJyp5wp-QxdH7yb0G17G1O16vr9YbFiRSlFXuaSDdTNgYLQxRisqzahWeuwqyip9klX_0kP8NWo7Ou1NX_oGC3_AYSTegU</recordid><startdate>19970101</startdate><enddate>19970101</enddate><creator>Hosogi, S</creator><creator>Araki, J</creator><creator>Syuu, Y</creator><creator>Suzuki, S</creator><creator>Mohri, S</creator><creator>Mikane, T</creator><creator>Matsubara, H</creator><creator>Ohe, T</creator><creator>Hirakawa, M</creator><creator>Suga, H</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>19970101</creationdate><title>Calcium equally increases the internal calcium recirculation fraction before and after beta-blockade in canine left ventricles</title><author>Hosogi, S ; Araki, J ; Syuu, Y ; Suzuki, S ; Mohri, S ; Mikane, T ; Matsubara, H ; Ohe, T ; Hirakawa, M ; Suga, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-c347f2c32422c2299ad51331d74d69cd636c60dc930c56db51cbfcd2024f9fd83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adenosine Monophosphate - metabolism</topic><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Alternan</topic><topic>Animals</topic><topic>Arrhythmias, Cardiac - drug therapy</topic><topic>Arrhythmias, Cardiac - metabolism</topic><topic>Arrhythmias, Cardiac - physiopathology</topic><topic>Calcium</topic><topic>Calcium - administration & dosage</topic><topic>Calcium - pharmacokinetics</topic><topic>Calcium Channels - drug effects</topic><topic>Calcium Channels - metabolism</topic><topic>Contractility</topic><topic>Coronary Vessels</topic><topic>Cyclic AMP</topic><topic>Decay</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Electrocardiography - drug effects</topic><topic>Heart</topic><topic>Heart Ventricles - drug effects</topic><topic>Heart Ventricles - metabolism</topic><topic>Heart Ventricles - physiopathology</topic><topic>Injections, Intra-Arterial</topic><topic>Myocardial Contraction - drug effects</topic><topic>Phosphorylation</topic><topic>Propranolol</topic><topic>Propranolol - pharmacology</topic><topic>Time constant</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosogi, S</creatorcontrib><creatorcontrib>Araki, J</creatorcontrib><creatorcontrib>Syuu, Y</creatorcontrib><creatorcontrib>Suzuki, S</creatorcontrib><creatorcontrib>Mohri, S</creatorcontrib><creatorcontrib>Mikane, T</creatorcontrib><creatorcontrib>Matsubara, H</creatorcontrib><creatorcontrib>Ohe, T</creatorcontrib><creatorcontrib>Hirakawa, M</creatorcontrib><creatorcontrib>Suga, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Heart and vessels</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hosogi, S</au><au>Araki, J</au><au>Syuu, Y</au><au>Suzuki, S</au><au>Mohri, S</au><au>Mikane, T</au><au>Matsubara, H</au><au>Ohe, T</au><au>Hirakawa, M</au><au>Suga, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium equally increases the internal calcium recirculation fraction before and after beta-blockade in canine left ventricles</atitle><jtitle>Heart and vessels</jtitle><addtitle>Heart Vessels</addtitle><date>1997-01-01</date><risdate>1997</risdate><volume>12</volume><issue>6</issue><spage>280</spage><epage>286</epage><pages>280-286</pages><issn>0910-8327</issn><eissn>1615-2573</eissn><abstract>We studied whether intracoronary Ca administration after beta-blockade would increase the internal Ca recirculation fraction (RF) analogously to the Ca administration before beta-blockade. This was performed in excised cross-circulated canine hearts. We analyzed the exponential decay component of the postextrasystolic potentiation (PESP) following a spontaneous extrasystole. All the PESPs decayed in alternans with atrial pacing at a constant rate. We obtained the time constant (tau(e)) of the monoexponential decay component of the alternans PESP. An increment of intracoronary Ca by 1.5 mmol/l enhanced the left ventricular contractility index Emax (end-systolic maximum elastance) by 2.5 times before and after beta-blockade with propranolol. The intracoronary Ca after beta-blockade slightly but significantly increased tau(e), and hence increased RF calculated from tau(e) by RF = exp(-1/tau(e)). This was analogous to the slightly increased tau(e) and RF with Ca before beta-blockade. We speculate that the myocardial cyclic AMP-dependent phosphorylation level would not significantly alter the effect of intracoronarily administered Ca on myocardial Ca handling, in terms of tau(e) and RF.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>9860195</pmid><doi>10.1007/BF02766804</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenosine Monophosphate - metabolism Adrenergic beta-Antagonists - pharmacology Alternan Animals Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology Calcium Calcium - administration & dosage Calcium - pharmacokinetics Calcium Channels - drug effects Calcium Channels - metabolism Contractility Coronary Vessels Cyclic AMP Decay Disease Models, Animal Dogs Electrocardiography - drug effects Heart Heart Ventricles - drug effects Heart Ventricles - metabolism Heart Ventricles - physiopathology Injections, Intra-Arterial Myocardial Contraction - drug effects Phosphorylation Propranolol Propranolol - pharmacology Time constant Ventricle |
| title | Calcium equally increases the internal calcium recirculation fraction before and after beta-blockade in canine left ventricles |
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