Synthesis of mono-fluorinated heterocycles with a ring-junction nitrogen atom via Rh(iii)-catalyzed CF3-carbenoid C–H functionalization and defluorinative annulation

A Rh(iii)-catalyzed defluorinative [4 + 2] annulation of 2-aryl indoles with ethyl 2-diazo-3,3,3-trifluoropropanoate for the synthesis of 6-fluoro-indolo[2,1-a]isoquinolines has been developed. The reaction involves the regioselective CF3-carbenoid C–H functionalization of 2-aryl indoles and consecu...

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Veröffentlicht in:	Organic chemistry frontiers an international journal of organic chemistry 2023-03, Vol.10 (6), p.1544-1550
Hauptverfasser:	Li, Haosheng, Mingjing Mei, Wang, Duozhi, Zhou, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatic compounds Azoles Chemical reactions Chemical synthesis Fluorides Fluorination Functional groups Heterocyclic compounds Indoles Nitrogen Nucleophiles Organic chemistry Pyridines
Online-Zugang:	Volltext
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