Transient normoprolactinemic galactorrhea induced by fluoxetine

Transient normoprolactinemic galactorrhea induced by fluoxetine

Hormonal side effects of antidepressants are infrequent. Galactorrhea is rarely reported among antidepressant related side effects. Antidepressants can directly stimu­late postsynaptic 5- Hydroxytryptamine (5-HT) receptors in the hypothalamus or indirectly inhibit the tuberoinfun­dibular dopaminergi...

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Veröffentlicht in:Journal of clinical and experimental investigations 2013-03, Vol.4 (1), p.105
Hauptverfasser: Canan, Fatih, Aydinoglu, Unsal, Sinani, Gjergji
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Aydinoglu, Unsal
Sinani, Gjergji
description Hormonal side effects of antidepressants are infrequent. Galactorrhea is rarely reported among antidepressant related side effects. Antidepressants can directly stimu­late postsynaptic 5- Hydroxytryptamine (5-HT) receptors in the hypothalamus or indirectly inhibit the tuberoinfun­dibular dopaminergic neurons through 5-HT, which may increase prolactin levels and later cause galactorrhea. However, galactorrhea may develop despite normal pro­lactin levels during antidepressant treatment. We present a case of normoprolactinemic galactorrhea in a woman, related with fluoxetine treatment. This report highlights the presence of unidentified mechanisms of selective serotonin reuptake inhibitor induced galactorrhea.
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title Transient normoprolactinemic galactorrhea induced by fluoxetine
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