Prevalence of asymptomatic nonalcoholic fatty liver disease in nondiabetic participants: a study from south india
Background Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that is rapidly increasing worldwide. Aim The aim of this study was to investigate the risk factors associated with NAFLD in nondiabetics from South India. Participants and methods We recruited 345 asymptomatic participa...
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| Veröffentlicht in: | The Egyptian journal of internal medicine 2019-03, Vol.31 (1), p.92-98 |
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| creator | Bandaru, V. C. S. Srinivasarao Chaudhury, Jaydip R. Lalitha, Palle Reddy, Somala N. Misra, Pradeep K. Balaraju, Banda Mridula, Kandadai R. |
| description | Background
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that is rapidly increasing worldwide.
Aim
The aim of this study was to investigate the risk factors associated with NAFLD in nondiabetics from South India.
Participants and methods
We recruited 345 asymptomatic participants consecutively, and the study period was between January 2014 and December 2017. All participants underwent risk factor evaluation, fasting serum lipid profile, C-reactive protein (CRP), hemoglobin A1c, liver function test, and abdominal ultrasound.
Results
Of 345 participants, men represented 213 (71%). The mean age of the participants was 58.4±11.1 years, with age range from 24–68 years. Prevalence of NAFLD was seen in 22%. On risk factor evaluation, 107 (31%) were hypertensive, 89 (25.7%) smoked, 52 (15%) were overweight, 110 (24.9%) were obese, and 113 (32.7%) had dyslipidemia. The mean CRP was 12.7±9.5 mg/l. High γ-glutamyl transferase levels, elevated CRP levels, obesity (45, 59.2%), high total cholesterol (49, 64.4%), low levels of high-density lipoprotein (28, 36.8%), high levels of low-density lipoprotein (27, 35.5%), and high triglycerides (31, 40.7%) were significantly associated with NALFD compared with non-NAFLD. After adjustment using multiple regression analysis, obesity (odds ratio: 3.5; 95% CI: 2.18–6.16), high total cholesterol [odds ratio: 4.9; 95% confidence interval (CI): 2.91–9.43], low high-density lipoprotein (odds ratio: 2.3; 95% CI: 1.20–4.47), high low-density lipoprotein (odds ratio: 2.9; 95% CI: 1.58–6.17), high triglycerides (odds ratio: 2.4; 95% CI: 1.33–4.60), and elevated CRP levels (odds ratio: 2.0; 95% CI: 1.21–3.39) were significantly associated with NAFLD.
Conclusion
Our study established obesity, CRP positivity, and dyslipidemia as independently associated with NAFLD in South Indian patients. |
| doi_str_mv | 10.4103/ejim.ejim_76_18 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2785246567</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2785246567</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1968-e7e54e21f4f4de24725742e0ef774d5a78f258f0d4ab38b2fc94d038c3cbc60d3</originalsourceid><addsrcrecordid>eNp1kM9LwzAcxYMoOObOXgOeuyVp0qTeZPgLBnrQc0nTb1xG23RJO-h_b-sET16-jy983oP3ELqlZM0pSTdwcM16PoXMCqou0IKRnCQ5ydUlWlBKSSKlYtdoFaMriaBECZGTBTq-BzjpGloD2Fus49h0vW907wxufatr4_e-nh6r-37EtTtBwJWLoCNg185M5XQJM9_pMInrdNvHe6xx7IdqxDb4Bkc_9PuJn9gbdGV1HWH1q0v0-fT4sX1Jdm_Pr9uHXWJonqkEJAgOjFpueQWMSyYkZ0DASskroaWyTChLKq7LVJXMmpxXJFUmNaXJSJUu0d05twv-OEDsi4MfwtQoFkwqwXgmMjlRmzNlgo8xgC264BodxoKSYp62-Fn1b9rJQc6OOJHtF4S_3P8s30aGghc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2785246567</pqid></control><display><type>article</type><title>Prevalence of asymptomatic nonalcoholic fatty liver disease in nondiabetic participants: a study from south india</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><creator>Bandaru, V. C. S. Srinivasarao ; Chaudhury, Jaydip R. ; Lalitha, Palle ; Reddy, Somala N. ; Misra, Pradeep K. ; Balaraju, Banda ; Mridula, Kandadai R.</creator><creatorcontrib>Bandaru, V. C. S. Srinivasarao ; Chaudhury, Jaydip R. ; Lalitha, Palle ; Reddy, Somala N. ; Misra, Pradeep K. ; Balaraju, Banda ; Mridula, Kandadai R.</creatorcontrib><description>Background
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that is rapidly increasing worldwide.
Aim
The aim of this study was to investigate the risk factors associated with NAFLD in nondiabetics from South India.
Participants and methods
We recruited 345 asymptomatic participants consecutively, and the study period was between January 2014 and December 2017. All participants underwent risk factor evaluation, fasting serum lipid profile, C-reactive protein (CRP), hemoglobin A1c, liver function test, and abdominal ultrasound.
Results
Of 345 participants, men represented 213 (71%). The mean age of the participants was 58.4±11.1 years, with age range from 24–68 years. Prevalence of NAFLD was seen in 22%. On risk factor evaluation, 107 (31%) were hypertensive, 89 (25.7%) smoked, 52 (15%) were overweight, 110 (24.9%) were obese, and 113 (32.7%) had dyslipidemia. The mean CRP was 12.7±9.5 mg/l. High γ-glutamyl transferase levels, elevated CRP levels, obesity (45, 59.2%), high total cholesterol (49, 64.4%), low levels of high-density lipoprotein (28, 36.8%), high levels of low-density lipoprotein (27, 35.5%), and high triglycerides (31, 40.7%) were significantly associated with NALFD compared with non-NAFLD. After adjustment using multiple regression analysis, obesity (odds ratio: 3.5; 95% CI: 2.18–6.16), high total cholesterol [odds ratio: 4.9; 95% confidence interval (CI): 2.91–9.43], low high-density lipoprotein (odds ratio: 2.3; 95% CI: 1.20–4.47), high low-density lipoprotein (odds ratio: 2.9; 95% CI: 1.58–6.17), high triglycerides (odds ratio: 2.4; 95% CI: 1.33–4.60), and elevated CRP levels (odds ratio: 2.0; 95% CI: 1.21–3.39) were significantly associated with NAFLD.
Conclusion
Our study established obesity, CRP positivity, and dyslipidemia as independently associated with NAFLD in South Indian patients.</description><identifier>ISSN: 1110-7782</identifier><identifier>EISSN: 2090-9098</identifier><identifier>DOI: 10.4103/ejim.ejim_76_18</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Asymptomatic ; High density lipoprotein ; Internal Medicine ; Lipoproteins ; Liver diseases ; Medicine & Public Health ; Metabolic disorders ; Obesity ; Original Article ; Triglycerides</subject><ispartof>The Egyptian journal of internal medicine, 2019-03, Vol.31 (1), p.92-98</ispartof><rights>2019 The Egyptian Journal of Internal Medicine 2019</rights><rights>2019 The Egyptian Journal of Internal Medicine 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1968-e7e54e21f4f4de24725742e0ef774d5a78f258f0d4ab38b2fc94d038c3cbc60d3</citedby><cites>FETCH-LOGICAL-c1968-e7e54e21f4f4de24725742e0ef774d5a78f258f0d4ab38b2fc94d038c3cbc60d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.4103/ejim.ejim_76_18$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://doi.org/10.4103/ejim.ejim_76_18$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,27901,27902,41096,42165,51551</link.rule.ids></links><search><creatorcontrib>Bandaru, V. C. S. Srinivasarao</creatorcontrib><creatorcontrib>Chaudhury, Jaydip R.</creatorcontrib><creatorcontrib>Lalitha, Palle</creatorcontrib><creatorcontrib>Reddy, Somala N.</creatorcontrib><creatorcontrib>Misra, Pradeep K.</creatorcontrib><creatorcontrib>Balaraju, Banda</creatorcontrib><creatorcontrib>Mridula, Kandadai R.</creatorcontrib><title>Prevalence of asymptomatic nonalcoholic fatty liver disease in nondiabetic participants: a study from south india</title><title>The Egyptian journal of internal medicine</title><addtitle>Egypt J Intern Med</addtitle><description>Background
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that is rapidly increasing worldwide.
Aim
The aim of this study was to investigate the risk factors associated with NAFLD in nondiabetics from South India.
Participants and methods
We recruited 345 asymptomatic participants consecutively, and the study period was between January 2014 and December 2017. All participants underwent risk factor evaluation, fasting serum lipid profile, C-reactive protein (CRP), hemoglobin A1c, liver function test, and abdominal ultrasound.
Results
Of 345 participants, men represented 213 (71%). The mean age of the participants was 58.4±11.1 years, with age range from 24–68 years. Prevalence of NAFLD was seen in 22%. On risk factor evaluation, 107 (31%) were hypertensive, 89 (25.7%) smoked, 52 (15%) were overweight, 110 (24.9%) were obese, and 113 (32.7%) had dyslipidemia. The mean CRP was 12.7±9.5 mg/l. High γ-glutamyl transferase levels, elevated CRP levels, obesity (45, 59.2%), high total cholesterol (49, 64.4%), low levels of high-density lipoprotein (28, 36.8%), high levels of low-density lipoprotein (27, 35.5%), and high triglycerides (31, 40.7%) were significantly associated with NALFD compared with non-NAFLD. After adjustment using multiple regression analysis, obesity (odds ratio: 3.5; 95% CI: 2.18–6.16), high total cholesterol [odds ratio: 4.9; 95% confidence interval (CI): 2.91–9.43], low high-density lipoprotein (odds ratio: 2.3; 95% CI: 1.20–4.47), high low-density lipoprotein (odds ratio: 2.9; 95% CI: 1.58–6.17), high triglycerides (odds ratio: 2.4; 95% CI: 1.33–4.60), and elevated CRP levels (odds ratio: 2.0; 95% CI: 1.21–3.39) were significantly associated with NAFLD.
Conclusion
Our study established obesity, CRP positivity, and dyslipidemia as independently associated with NAFLD in South Indian patients.</description><subject>Asymptomatic</subject><subject>High density lipoprotein</subject><subject>Internal Medicine</subject><subject>Lipoproteins</subject><subject>Liver diseases</subject><subject>Medicine & Public Health</subject><subject>Metabolic disorders</subject><subject>Obesity</subject><subject>Original Article</subject><subject>Triglycerides</subject><issn>1110-7782</issn><issn>2090-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kM9LwzAcxYMoOObOXgOeuyVp0qTeZPgLBnrQc0nTb1xG23RJO-h_b-sET16-jy983oP3ELqlZM0pSTdwcM16PoXMCqou0IKRnCQ5ydUlWlBKSSKlYtdoFaMriaBECZGTBTq-BzjpGloD2Fus49h0vW907wxufatr4_e-nh6r-37EtTtBwJWLoCNg185M5XQJM9_pMInrdNvHe6xx7IdqxDb4Bkc_9PuJn9gbdGV1HWH1q0v0-fT4sX1Jdm_Pr9uHXWJonqkEJAgOjFpueQWMSyYkZ0DASskroaWyTChLKq7LVJXMmpxXJFUmNaXJSJUu0d05twv-OEDsi4MfwtQoFkwqwXgmMjlRmzNlgo8xgC264BodxoKSYp62-Fn1b9rJQc6OOJHtF4S_3P8s30aGghc</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Bandaru, V. C. S. Srinivasarao</creator><creator>Chaudhury, Jaydip R.</creator><creator>Lalitha, Palle</creator><creator>Reddy, Somala N.</creator><creator>Misra, Pradeep K.</creator><creator>Balaraju, Banda</creator><creator>Mridula, Kandadai R.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20190301</creationdate><title>Prevalence of asymptomatic nonalcoholic fatty liver disease in nondiabetic participants: a study from south india</title><author>Bandaru, V. C. S. Srinivasarao ; Chaudhury, Jaydip R. ; Lalitha, Palle ; Reddy, Somala N. ; Misra, Pradeep K. ; Balaraju, Banda ; Mridula, Kandadai R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1968-e7e54e21f4f4de24725742e0ef774d5a78f258f0d4ab38b2fc94d038c3cbc60d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Asymptomatic</topic><topic>High density lipoprotein</topic><topic>Internal Medicine</topic><topic>Lipoproteins</topic><topic>Liver diseases</topic><topic>Medicine & Public Health</topic><topic>Metabolic disorders</topic><topic>Obesity</topic><topic>Original Article</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bandaru, V. C. S. Srinivasarao</creatorcontrib><creatorcontrib>Chaudhury, Jaydip R.</creatorcontrib><creatorcontrib>Lalitha, Palle</creatorcontrib><creatorcontrib>Reddy, Somala N.</creatorcontrib><creatorcontrib>Misra, Pradeep K.</creatorcontrib><creatorcontrib>Balaraju, Banda</creatorcontrib><creatorcontrib>Mridula, Kandadai R.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>The Egyptian journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bandaru, V. C. S. Srinivasarao</au><au>Chaudhury, Jaydip R.</au><au>Lalitha, Palle</au><au>Reddy, Somala N.</au><au>Misra, Pradeep K.</au><au>Balaraju, Banda</au><au>Mridula, Kandadai R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of asymptomatic nonalcoholic fatty liver disease in nondiabetic participants: a study from south india</atitle><jtitle>The Egyptian journal of internal medicine</jtitle><stitle>Egypt J Intern Med</stitle><date>2019-03-01</date><risdate>2019</risdate><volume>31</volume><issue>1</issue><spage>92</spage><epage>98</epage><pages>92-98</pages><issn>1110-7782</issn><eissn>2090-9098</eissn><abstract>Background
Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that is rapidly increasing worldwide.
Aim
The aim of this study was to investigate the risk factors associated with NAFLD in nondiabetics from South India.
Participants and methods
We recruited 345 asymptomatic participants consecutively, and the study period was between January 2014 and December 2017. All participants underwent risk factor evaluation, fasting serum lipid profile, C-reactive protein (CRP), hemoglobin A1c, liver function test, and abdominal ultrasound.
Results
Of 345 participants, men represented 213 (71%). The mean age of the participants was 58.4±11.1 years, with age range from 24–68 years. Prevalence of NAFLD was seen in 22%. On risk factor evaluation, 107 (31%) were hypertensive, 89 (25.7%) smoked, 52 (15%) were overweight, 110 (24.9%) were obese, and 113 (32.7%) had dyslipidemia. The mean CRP was 12.7±9.5 mg/l. High γ-glutamyl transferase levels, elevated CRP levels, obesity (45, 59.2%), high total cholesterol (49, 64.4%), low levels of high-density lipoprotein (28, 36.8%), high levels of low-density lipoprotein (27, 35.5%), and high triglycerides (31, 40.7%) were significantly associated with NALFD compared with non-NAFLD. After adjustment using multiple regression analysis, obesity (odds ratio: 3.5; 95% CI: 2.18–6.16), high total cholesterol [odds ratio: 4.9; 95% confidence interval (CI): 2.91–9.43], low high-density lipoprotein (odds ratio: 2.3; 95% CI: 1.20–4.47), high low-density lipoprotein (odds ratio: 2.9; 95% CI: 1.58–6.17), high triglycerides (odds ratio: 2.4; 95% CI: 1.33–4.60), and elevated CRP levels (odds ratio: 2.0; 95% CI: 1.21–3.39) were significantly associated with NAFLD.
Conclusion
Our study established obesity, CRP positivity, and dyslipidemia as independently associated with NAFLD in South Indian patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.4103/ejim.ejim_76_18</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Asymptomatic High density lipoprotein Internal Medicine Lipoproteins Liver diseases Medicine & Public Health Metabolic disorders Obesity Original Article Triglycerides |
| title | Prevalence of asymptomatic nonalcoholic fatty liver disease in nondiabetic participants: a study from south india |
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