Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis

FUNDING. German Research Foundation (DFG), under Germany's Excellence Strategy (EXC 2167-390884018 "Precision Medicine in Chronic Inflammation" and EXC 2051-390713860 "Balance of the Microverse"); Oskar Helene Heim Stiftung; Christiane Herzog Stiftung; Mukoviszidose Institut...

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Veröffentlicht in:	The Journal of clinical investigation 2023-03, Vol.133 (5), p.1-16
Hauptverfasser:	Schwarz, Carsten, Eschenhagen, Patience, Schmid, Henrijette, Hohnstein, Thordis, Grehn, Claudia, Iwert, Christina, Roehmel, Jobst, Steinke, Eva, Stahl, Mirjam, Lozza, Laura, Tikhonova, Ekaterina, Rosati, Elisa, Stervbo, Ulrik, Babel, Nina, Mainz, Jochen G, Wisplinghoff, Hilmar, Ebel, Frank, Jia, Lei-Jie, Blango, Matthew G, Hortschansky, Peter, Brunke, Sascha, Hube, Bernhard, Brakhage, Axel A, Kniemeyer, Olaf, Scheffold, Alexander, Bacher, Petra
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic bronchopulmonary aspergillosis Antigen presentation Antigen-antibody reactions Antigens Aspergillosis Aspergillus fumigatus Avidity Biomedical research CD4 lymphocytes Cross reactions (Immunology) Cross-reactivity Cystic fibrosis Effector cells Fungal infections Fungi Health aspects Helper cells Immune response Inflammation Lungs Lymphocytes Lymphocytes T Medical research Medicine, Experimental Mycoses Pathogens Peripheral blood Phenotypes Physiological aspects Precision medicine Proteins Risk factors T cell receptors T cells
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Zusammenfassung:	FUNDING. German Research Foundation (DFG), under Germany's Excellence Strategy (EXC 2167-390884018 "Precision Medicine in Chronic Inflammation" and EXC 2051-390713860 "Balance of the Microverse"); Oskar Helene Heim Stiftung; Christiane Herzog Stiftung; Mukoviszidose Institut gGmb; German Cystic Fibrosis Association Mukoviszidose e.V; German Federal Ministry of Education and Science (BMBF) InfectControl 2020 Projects AnDiPath (BMBF 03ZZ0838A+B).
ISSN:	0021-9738 1558-8238
DOI:	10.1172/JCn61593