Pathophysiology and treatment of atherosclerosis
Recent years have brought a significant amount of new results in the field of atherosclerosis. A better understanding of the role of different lipoprotein particles in the formation of atherosclerotic plaques is now possible. Recent cardiovascular clinical trials have also shed more light upon the e...
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| Veröffentlicht in: | Netherlands heart journal 2017-04, Vol.25 (4), p.231-242 |
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| creator | Bergheanu, S. C Bodde, M. C Jukema, J. W |
| description | Recent years have brought a significant amount of new results in the field of atherosclerosis. A better understanding of the role of different lipoprotein particles in the formation of atherosclerotic plaques is now possible. Recent cardiovascular clinical trials have also shed more light upon the efficacy and safety of novel compounds targeting the main pathways of atherosclerosis and its cardiovascular complications.In this review, we first provide a background consisting of the current understanding of the pathophysiology and treatment of atherosclerotic disease, followed by our future perspectives on several novel classes of drugs that target atherosclerosis. The focus of this update is on the pathophysiology and medical interventions of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) and lipoprotein(a) (Lp(a)). |
| doi_str_mv | 10.1007/s12471-017-0959-2 |
| format | Article |
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| ispartof | Netherlands heart journal, 2017-04, Vol.25 (4), p.231-242 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Springer Nature OA Free Journals |
| subjects | Acute coronary syndromes Angina pectoris Atherosclerosis Cardiovascular disease Cholesterol Collagen Coronary vessels Disease prevention Heart attacks High density lipoprotein Lipids Lipoproteins Pathophysiology Statins Stroke Ultrasonic imaging |
| title | Pathophysiology and treatment of atherosclerosis |
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