Anti-Inflammatory Effects of Usnic Acid in Breast Cancer
Breast cancer is the most common type of cancer among women. Usnic acid has anticancer and anti-inflammatory potential. In this study, we evaluated the effects of usnic acid on inflammation and oxidative stress in the breast cancer cell line (MCF-7). Cyclooxygenase-2 (COX-2), inducible nitric oxide...
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| Veröffentlicht in: | Russian journal of bioorganic chemistry 2022-12, Vol.48 (Suppl 1), p.S110-S114 |
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| container_issue | Suppl 1 |
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| container_title | Russian journal of bioorganic chemistry |
| container_volume | 48 |
| creator | Yildirim, M. Degirmenci, U. Akkapulu, M. Gungor, M. Oztornacı, R. O. Berkoz, M. Comelekoglu, U. Yalın, A. E. Yalın, S. |
| description | Breast cancer is the most common type of cancer among women. Usnic acid has anticancer and anti-inflammatory potential. In this study, we evaluated the effects of usnic acid on inflammation and oxidative stress in the breast cancer cell line (MCF-7). Cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) gene expression, cytokines, nitric oxide (NO), prostaglandin E2 (PGE
2
) levels and oxidative stress were measured in all groups. Our study showed that usnic acid was decreased NO, VEGF, PGE
2
levels, gene expression levels of COX-2 and iNOS in the meantime cytokines (IL 2, CXCL 10, CXCL8, CCL2 (MCP-1), TNF-α, IL-6), glutathione levels, moreover decreased GSH and increased MDA levels in dose depended manner. According to our evidence usnic acid was showed potential cytotoxic, anti-inflammatory and pro-oxidant role. |
| doi_str_mv | 10.1134/S1068162023010296 |
| format | Article |
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2
) levels and oxidative stress were measured in all groups. Our study showed that usnic acid was decreased NO, VEGF, PGE
2
levels, gene expression levels of COX-2 and iNOS in the meantime cytokines (IL 2, CXCL 10, CXCL8, CCL2 (MCP-1), TNF-α, IL-6), glutathione levels, moreover decreased GSH and increased MDA levels in dose depended manner. According to our evidence usnic acid was showed potential cytotoxic, anti-inflammatory and pro-oxidant role.</description><identifier>ISSN: 1068-1620</identifier><identifier>EISSN: 1608-330X</identifier><identifier>DOI: 10.1134/S1068162023010296</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Breast cancer ; Cytokines ; Gene expression ; Glutathione ; Life Sciences ; Nitric oxide ; Organic Chemistry ; Oxidizing agents</subject><ispartof>Russian journal of bioorganic chemistry, 2022-12, Vol.48 (Suppl 1), p.S110-S114</ispartof><rights>Pleiades Publishing, Ltd. 2022. ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2022, Vol. 48, Suppl. 1, pp. S110–S114. © Pleiades Publishing, Ltd., 2022. ISSN 1068-1620, Russian Journal of Bioorganic Chemistry, 2022. © Pleiades Publishing, Ltd., 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c198t-e5d16bcb0457726c330b4180c55ed2d055dc79f1ecf84748616d10083ed2fff33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1068162023010296$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1068162023010296$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids></links><search><creatorcontrib>Yildirim, M.</creatorcontrib><creatorcontrib>Degirmenci, U.</creatorcontrib><creatorcontrib>Akkapulu, M.</creatorcontrib><creatorcontrib>Gungor, M.</creatorcontrib><creatorcontrib>Oztornacı, R. O.</creatorcontrib><creatorcontrib>Berkoz, M.</creatorcontrib><creatorcontrib>Comelekoglu, U.</creatorcontrib><creatorcontrib>Yalın, A. E.</creatorcontrib><creatorcontrib>Yalın, S.</creatorcontrib><title>Anti-Inflammatory Effects of Usnic Acid in Breast Cancer</title><title>Russian journal of bioorganic chemistry</title><addtitle>Russ J Bioorg Chem</addtitle><description>Breast cancer is the most common type of cancer among women. Usnic acid has anticancer and anti-inflammatory potential. In this study, we evaluated the effects of usnic acid on inflammation and oxidative stress in the breast cancer cell line (MCF-7). Cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) gene expression, cytokines, nitric oxide (NO), prostaglandin E2 (PGE
2
) levels and oxidative stress were measured in all groups. Our study showed that usnic acid was decreased NO, VEGF, PGE
2
levels, gene expression levels of COX-2 and iNOS in the meantime cytokines (IL 2, CXCL 10, CXCL8, CCL2 (MCP-1), TNF-α, IL-6), glutathione levels, moreover decreased GSH and increased MDA levels in dose depended manner. According to our evidence usnic acid was showed potential cytotoxic, anti-inflammatory and pro-oxidant role.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Breast cancer</subject><subject>Cytokines</subject><subject>Gene expression</subject><subject>Glutathione</subject><subject>Life Sciences</subject><subject>Nitric oxide</subject><subject>Organic Chemistry</subject><subject>Oxidizing agents</subject><issn>1068-1620</issn><issn>1608-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kEFLxDAQhYMouK7-AG8Bz9WZpEnTY11WXVjwoAveSpsm0mWbrkn2sP_eLBU8iKcZeN-beTxCbhHuEXn-8IYgFUoGjAMCK-UZmaEElXEOH-dpT3J20i_JVQhbSBAINSOqcrHPVs7ummFo4uiPdGmt0THQ0dJNcL2mle472jv66E0TIl00Tht_TS5sswvm5mfOyeZp-b54ydavz6tFtc40lipmRnQoW91CLoqCSZ3itDkq0EKYjnUgRKeL0qLRVuVFriTKLkVTPKnWWs7n5G66u_fj18GEWG_Hg3fpZc0KhazAHESicKK0H0PwxtZ73w-NP9YI9amg-k9BycMmT0is-zT-9_L_pm9J1WTR</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Yildirim, M.</creator><creator>Degirmenci, U.</creator><creator>Akkapulu, M.</creator><creator>Gungor, M.</creator><creator>Oztornacı, R. O.</creator><creator>Berkoz, M.</creator><creator>Comelekoglu, U.</creator><creator>Yalın, A. E.</creator><creator>Yalın, S.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20221201</creationdate><title>Anti-Inflammatory Effects of Usnic Acid in Breast Cancer</title><author>Yildirim, M. ; Degirmenci, U. ; Akkapulu, M. ; Gungor, M. ; Oztornacı, R. O. ; Berkoz, M. ; Comelekoglu, U. ; Yalın, A. E. ; Yalın, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c198t-e5d16bcb0457726c330b4180c55ed2d055dc79f1ecf84748616d10083ed2fff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Breast cancer</topic><topic>Cytokines</topic><topic>Gene expression</topic><topic>Glutathione</topic><topic>Life Sciences</topic><topic>Nitric oxide</topic><topic>Organic Chemistry</topic><topic>Oxidizing agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yildirim, M.</creatorcontrib><creatorcontrib>Degirmenci, U.</creatorcontrib><creatorcontrib>Akkapulu, M.</creatorcontrib><creatorcontrib>Gungor, M.</creatorcontrib><creatorcontrib>Oztornacı, R. O.</creatorcontrib><creatorcontrib>Berkoz, M.</creatorcontrib><creatorcontrib>Comelekoglu, U.</creatorcontrib><creatorcontrib>Yalın, A. E.</creatorcontrib><creatorcontrib>Yalın, S.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of bioorganic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yildirim, M.</au><au>Degirmenci, U.</au><au>Akkapulu, M.</au><au>Gungor, M.</au><au>Oztornacı, R. O.</au><au>Berkoz, M.</au><au>Comelekoglu, U.</au><au>Yalın, A. E.</au><au>Yalın, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Inflammatory Effects of Usnic Acid in Breast Cancer</atitle><jtitle>Russian journal of bioorganic chemistry</jtitle><stitle>Russ J Bioorg Chem</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>48</volume><issue>Suppl 1</issue><spage>S110</spage><epage>S114</epage><pages>S110-S114</pages><issn>1068-1620</issn><eissn>1608-330X</eissn><abstract>Breast cancer is the most common type of cancer among women. Usnic acid has anticancer and anti-inflammatory potential. In this study, we evaluated the effects of usnic acid on inflammation and oxidative stress in the breast cancer cell line (MCF-7). Cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS) gene expression, cytokines, nitric oxide (NO), prostaglandin E2 (PGE
2
) levels and oxidative stress were measured in all groups. Our study showed that usnic acid was decreased NO, VEGF, PGE
2
levels, gene expression levels of COX-2 and iNOS in the meantime cytokines (IL 2, CXCL 10, CXCL8, CCL2 (MCP-1), TNF-α, IL-6), glutathione levels, moreover decreased GSH and increased MDA levels in dose depended manner. According to our evidence usnic acid was showed potential cytotoxic, anti-inflammatory and pro-oxidant role.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1068162023010296</doi></addata></record> |
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| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Breast cancer Cytokines Gene expression Glutathione Life Sciences Nitric oxide Organic Chemistry Oxidizing agents |
| title | Anti-Inflammatory Effects of Usnic Acid in Breast Cancer |
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