Regulator of G‐Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l‐Dopa‐induced dyskinesia

Background and Purpose Regulator of G‐protein signalling 4 (RGS4) is a signal transduction protein that accelerates intrinsic GTPase activity of Gαi/o and Gαq subunits, suppressing GPCR signalling. Here, we investigate whether RGS4 modulates nociceptin/orphanin FQ (N/OFQ) opioid (NOP) receptor signa...

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Veröffentlicht in:	British journal of pharmacology 2023-04, Vol.180 (7), p.927-942
Hauptverfasser:	Pisanò, Clarissa A., Mercatelli, Daniela, Mazzocchi, Martina, Brugnoli, Alberto, Morella, Ilaria, Fasano, Stefania, Zaveri, Nurulain T., Brambilla, Riccardo, O'Keeffe, Gerard W., Neubig, Richard R., Morari, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Analgesics, Opioid Animals AT‐403 Brain slice preparation CCG‐203920 Cyclic AMP Dopamine D1 receptors Dyskinesia Dyskinesia, Drug-Induced - drug therapy G protein-coupled receptors HEK293 Cells Humans Levodopa Levodopa - pharmacology l‐Dopa Mice Narcotics Neostriatum Nociceptin nociceptin/orphanin FQ Opioid receptors Proteins Rats Receptors, Opioid - metabolism RGS4 Signal Transduction
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