Role of apparent diffusion coefficient in assessment of loco-regional nodal spread in cancer rectum: correlative study with histopathological findings
Background Rectal cancer is associated with high morbidity and mortality rates. Preoperative assessment and detection of nodal metastasis are crucial for selecting a proper treatment plan. Diffusion-weighted imaging is considered to be a crucial functional imaging technique that can aid in determini...
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| Veröffentlicht in: | Egyptian Journal of Radiology and Nuclear Medicine 2023-12, Vol.54 (1), p.48-8, Article 48 |
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| creator | Osman, Mohamed Fouad Ibrahim, Shimaa Hamed Ghoneim, Shereen Mohammed Mahmoud Ali, Rasha Mostafa Mohamed Sedqi, Mohamed Emam Mohamed Gadalla, Amr A. Elfattah Hassan |
| description | Background
Rectal cancer is associated with high morbidity and mortality rates. Preoperative assessment and detection of nodal metastasis are crucial for selecting a proper treatment plan. Diffusion-weighted imaging is considered to be a crucial functional imaging technique that can aid in determining the condition of lymph nodes. This study aimed to assess the diagnostic utility of MRI functional images by use of apparent diffusion coefficient in regional nodal assessment in rectal cancer.
Results
This study included 54 patients including 29 males (53.7%) and 25 females (46.3%) presented with pathologically proven rectal cancer. Regarding rectal adenocarcinoma, functional MRI imaging using ADC values found to have a better sensitivity (86.24%) in detection of regional nodal metastasis than conventional morphological MRI criteria with 1.05 × 10
−3
mm
2
/s was employed as cutoff value to distinguish metastatic from non-metastatic lymph nodes with statistically significant
P
value ( |
| doi_str_mv | 10.1186/s43055-023-00995-1 |
| format | Article |
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Rectal cancer is associated with high morbidity and mortality rates. Preoperative assessment and detection of nodal metastasis are crucial for selecting a proper treatment plan. Diffusion-weighted imaging is considered to be a crucial functional imaging technique that can aid in determining the condition of lymph nodes. This study aimed to assess the diagnostic utility of MRI functional images by use of apparent diffusion coefficient in regional nodal assessment in rectal cancer.
Results
This study included 54 patients including 29 males (53.7%) and 25 females (46.3%) presented with pathologically proven rectal cancer. Regarding rectal adenocarcinoma, functional MRI imaging using ADC values found to have a better sensitivity (86.24%) in detection of regional nodal metastasis than conventional morphological MRI criteria with 1.05 × 10
−3
mm
2
/s was employed as cutoff value to distinguish metastatic from non-metastatic lymph nodes with statistically significant
P
value (< 0.001); nevertheless, regarding the accuracy there was no difference (68.52%). As regards mucinous and signet ring cell carcinoma, morphological assessment using conventional MRI sequences were found to have a better accuracy (72.96%) and sensitivity (57.69%) than ADC value, with the latter showed low statistically significant results (
P
- value < 0.201) in distinguishing metastatic and non-metastatic nodes. This could be explained by extremely high ADC values of nodes for these pathological types owing to their high mucin content.
Conclusions
MRI functional imaging using ADC values can be utilized to distinguish metastatic from non-metastatic lymph nodes in rectal adenocarcinoma employing diagnostic accuracy of 86.52%. However, morphological assessment using conventional MRI was found to be better in assessment of regional lymph nodes at mucinous and signet ring rectal carcinoma.</description><identifier>ISSN: 2090-4762</identifier><identifier>ISSN: 0378-603X</identifier><identifier>EISSN: 2090-4762</identifier><identifier>DOI: 10.1186/s43055-023-00995-1</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Apparent diffusion coefficient ; Cancer ; Colorectal cancer ; Females ; Health aspects ; Imaging ; Lymphatic system ; Magnetic resonance imaging ; Medical prognosis ; Medicine ; Medicine & Public Health ; Metastasis ; Morphology ; Mortality ; Nuclear Medicine ; Oncology, Experimental ; Patients ; Radiology ; Rectal cancer ; Rectum ; Regional lymph nodes</subject><ispartof>Egyptian Journal of Radiology and Nuclear Medicine, 2023-12, Vol.54 (1), p.48-8, Article 48</ispartof><rights>The Author(s) 2023</rights><rights>COPYRIGHT 2023 Springer</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-d8eb0487494620e13e8ec826d8c9c8eb5e16fc1ed46b9a36b2c862271b3ebd563</citedby><cites>FETCH-LOGICAL-c496t-d8eb0487494620e13e8ec826d8c9c8eb5e16fc1ed46b9a36b2c862271b3ebd563</cites><orcidid>0000-0002-6528-2147</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Osman, Mohamed Fouad</creatorcontrib><creatorcontrib>Ibrahim, Shimaa Hamed</creatorcontrib><creatorcontrib>Ghoneim, Shereen Mohammed Mahmoud</creatorcontrib><creatorcontrib>Ali, Rasha Mostafa Mohamed</creatorcontrib><creatorcontrib>Sedqi, Mohamed Emam Mohamed</creatorcontrib><creatorcontrib>Gadalla, Amr A. Elfattah Hassan</creatorcontrib><title>Role of apparent diffusion coefficient in assessment of loco-regional nodal spread in cancer rectum: correlative study with histopathological findings</title><title>Egyptian Journal of Radiology and Nuclear Medicine</title><addtitle>Egypt J Radiol Nucl Med</addtitle><description>Background
Rectal cancer is associated with high morbidity and mortality rates. Preoperative assessment and detection of nodal metastasis are crucial for selecting a proper treatment plan. Diffusion-weighted imaging is considered to be a crucial functional imaging technique that can aid in determining the condition of lymph nodes. This study aimed to assess the diagnostic utility of MRI functional images by use of apparent diffusion coefficient in regional nodal assessment in rectal cancer.
Results
This study included 54 patients including 29 males (53.7%) and 25 females (46.3%) presented with pathologically proven rectal cancer. Regarding rectal adenocarcinoma, functional MRI imaging using ADC values found to have a better sensitivity (86.24%) in detection of regional nodal metastasis than conventional morphological MRI criteria with 1.05 × 10
−3
mm
2
/s was employed as cutoff value to distinguish metastatic from non-metastatic lymph nodes with statistically significant
P
value (< 0.001); nevertheless, regarding the accuracy there was no difference (68.52%). As regards mucinous and signet ring cell carcinoma, morphological assessment using conventional MRI sequences were found to have a better accuracy (72.96%) and sensitivity (57.69%) than ADC value, with the latter showed low statistically significant results (
P
- value < 0.201) in distinguishing metastatic and non-metastatic nodes. This could be explained by extremely high ADC values of nodes for these pathological types owing to their high mucin content.
Conclusions
MRI functional imaging using ADC values can be utilized to distinguish metastatic from non-metastatic lymph nodes in rectal adenocarcinoma employing diagnostic accuracy of 86.52%. However, morphological assessment using conventional MRI was found to be better in assessment of regional lymph nodes at mucinous and signet ring rectal carcinoma.</description><subject>Apparent diffusion coefficient</subject><subject>Cancer</subject><subject>Colorectal cancer</subject><subject>Females</subject><subject>Health aspects</subject><subject>Imaging</subject><subject>Lymphatic system</subject><subject>Magnetic resonance imaging</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Morphology</subject><subject>Mortality</subject><subject>Nuclear Medicine</subject><subject>Oncology, Experimental</subject><subject>Patients</subject><subject>Radiology</subject><subject>Rectal cancer</subject><subject>Rectum</subject><subject>Regional lymph nodes</subject><issn>2090-4762</issn><issn>0378-603X</issn><issn>2090-4762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNp9Ul1r3iAYDWODlbZ_YFfCrtP5FTW7K2UfhUJhbNdi9DGvL0nM1Gz0j-z3zrcZ6wZjCn4czzno42maVwRfEaLEm8wZ7roWU9Zi3PddS541ZxT3uOVS0Od_rF82lzkfcW0cYyL4WfPjU5wARY_MupoES0EueL_lEBdkI3gfbDihYUEmZ8h5Pu0qf4o2tgnGSjQTWqKrY14TGHfiWrNYSCiBLdv8tjqlBJMp4RugXDb3gL6HckCHkEtcTTnEKY7BVgcfFheWMV80L7yZMlz-ms-bL-_ffb752N7df7i9ub5rLe9FaZ2CAXMlec8FxUAYKLCKCqdsb-tZB0R4S8BxMfSGiYFaJSiVZGAwuE6w8-Z293XRHPWawmzSg44m6EcgplGbVIKdQHs1UCUHZ-UA3BujhFdGsKFjynppZPV6vXutKX7dIBd9jFuq1cmaSkVwR7hST6zRVNOw-FiSsXPIVl9L1tOOS9VX1tU_WLU7mIONC_hQ8b8EdBfYFHNO4H8_hmB9SoneU6JrSvRjSjSpIraL6sfVqkN6uvF_VD8B4gTCEg</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Osman, Mohamed Fouad</creator><creator>Ibrahim, Shimaa Hamed</creator><creator>Ghoneim, Shereen Mohammed Mahmoud</creator><creator>Ali, Rasha Mostafa Mohamed</creator><creator>Sedqi, Mohamed Emam Mohamed</creator><creator>Gadalla, Amr A. Elfattah Hassan</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><general>SpringerOpen</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6528-2147</orcidid></search><sort><creationdate>20231201</creationdate><title>Role of apparent diffusion coefficient in assessment of loco-regional nodal spread in cancer rectum: correlative study with histopathological findings</title><author>Osman, Mohamed Fouad ; Ibrahim, Shimaa Hamed ; Ghoneim, Shereen Mohammed Mahmoud ; Ali, Rasha Mostafa Mohamed ; Sedqi, Mohamed Emam Mohamed ; Gadalla, Amr A. Elfattah Hassan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-d8eb0487494620e13e8ec826d8c9c8eb5e16fc1ed46b9a36b2c862271b3ebd563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apparent diffusion coefficient</topic><topic>Cancer</topic><topic>Colorectal cancer</topic><topic>Females</topic><topic>Health aspects</topic><topic>Imaging</topic><topic>Lymphatic system</topic><topic>Magnetic resonance imaging</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Morphology</topic><topic>Mortality</topic><topic>Nuclear Medicine</topic><topic>Oncology, Experimental</topic><topic>Patients</topic><topic>Radiology</topic><topic>Rectal cancer</topic><topic>Rectum</topic><topic>Regional lymph nodes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Osman, Mohamed Fouad</creatorcontrib><creatorcontrib>Ibrahim, Shimaa Hamed</creatorcontrib><creatorcontrib>Ghoneim, Shereen Mohammed Mahmoud</creatorcontrib><creatorcontrib>Ali, Rasha Mostafa Mohamed</creatorcontrib><creatorcontrib>Sedqi, Mohamed Emam Mohamed</creatorcontrib><creatorcontrib>Gadalla, Amr A. Elfattah Hassan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osman, Mohamed Fouad</au><au>Ibrahim, Shimaa Hamed</au><au>Ghoneim, Shereen Mohammed Mahmoud</au><au>Ali, Rasha Mostafa Mohamed</au><au>Sedqi, Mohamed Emam Mohamed</au><au>Gadalla, Amr A. Elfattah Hassan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of apparent diffusion coefficient in assessment of loco-regional nodal spread in cancer rectum: correlative study with histopathological findings</atitle><jtitle>Egyptian Journal of Radiology and Nuclear Medicine</jtitle><stitle>Egypt J Radiol Nucl Med</stitle><date>2023-12-01</date><risdate>2023</risdate><volume>54</volume><issue>1</issue><spage>48</spage><epage>8</epage><pages>48-8</pages><artnum>48</artnum><issn>2090-4762</issn><issn>0378-603X</issn><eissn>2090-4762</eissn><abstract>Background
Rectal cancer is associated with high morbidity and mortality rates. Preoperative assessment and detection of nodal metastasis are crucial for selecting a proper treatment plan. Diffusion-weighted imaging is considered to be a crucial functional imaging technique that can aid in determining the condition of lymph nodes. This study aimed to assess the diagnostic utility of MRI functional images by use of apparent diffusion coefficient in regional nodal assessment in rectal cancer.
Results
This study included 54 patients including 29 males (53.7%) and 25 females (46.3%) presented with pathologically proven rectal cancer. Regarding rectal adenocarcinoma, functional MRI imaging using ADC values found to have a better sensitivity (86.24%) in detection of regional nodal metastasis than conventional morphological MRI criteria with 1.05 × 10
−3
mm
2
/s was employed as cutoff value to distinguish metastatic from non-metastatic lymph nodes with statistically significant
P
value (< 0.001); nevertheless, regarding the accuracy there was no difference (68.52%). As regards mucinous and signet ring cell carcinoma, morphological assessment using conventional MRI sequences were found to have a better accuracy (72.96%) and sensitivity (57.69%) than ADC value, with the latter showed low statistically significant results (
P
- value < 0.201) in distinguishing metastatic and non-metastatic nodes. This could be explained by extremely high ADC values of nodes for these pathological types owing to their high mucin content.
Conclusions
MRI functional imaging using ADC values can be utilized to distinguish metastatic from non-metastatic lymph nodes in rectal adenocarcinoma employing diagnostic accuracy of 86.52%. However, morphological assessment using conventional MRI was found to be better in assessment of regional lymph nodes at mucinous and signet ring rectal carcinoma.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1186/s43055-023-00995-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6528-2147</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Apparent diffusion coefficient Cancer Colorectal cancer Females Health aspects Imaging Lymphatic system Magnetic resonance imaging Medical prognosis Medicine Medicine & Public Health Metastasis Morphology Mortality Nuclear Medicine Oncology, Experimental Patients Radiology Rectal cancer Rectum Regional lymph nodes |
| title | Role of apparent diffusion coefficient in assessment of loco-regional nodal spread in cancer rectum: correlative study with histopathological findings |
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