Arsenic Polyoxotungstate-Zeolitic Imidazolate Framework-8 as a Potential Selective Anti-cancer Nano Platform
A pH-sensitive nanoplatform of Pegylated Zeolitic Imidazolate Framework-8 (ZIF-8/PEG) was selected to modulate the cytotoxicity profile of arsenic polyoxotungstate (K6As2W18O62, KAW). The final nanoplatforms (NPs) showed a high loading content (31%) and a pH-responsive release of KAW. The in vitro c...
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| Veröffentlicht in: | Journal of inorganic and organometallic polymers and materials 2023-02, Vol.33 (2), p.611-624 |
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| container_title | Journal of inorganic and organometallic polymers and materials |
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| creator | Moazeni Bistgani, Zahra Shafiee, Fatemeh Varshosaz, Jaleh Kazemian, Hossein Tangestaninejad, Shahram Rostami, Mahboubeh |
| description | A pH-sensitive nanoplatform of Pegylated Zeolitic Imidazolate Framework-8 (ZIF-8/PEG) was selected to modulate the cytotoxicity profile of arsenic polyoxotungstate (K6As2W18O62, KAW). The final nanoplatforms (NPs) showed a high loading content (31%) and a pH-responsive release of KAW. The in vitro cytotoxicity experiments showed that the IC50 decreased to about half in designed NPs on MDA-MB-231 cancer cells with a better level of cellular uptake (92%) than in control KAW (62%). Also, the final pegylated NPs were safer than free KAW on normal cells (85 mg/mL versus 45 mg/mL). The in vitro study confirmed the higher potency of the designed NPs against breast cancer cells with lower side effects than free KAW.
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| doi_str_mv | 10.1007/s10904-022-02529-0 |
| format | Article |
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| subjects | Arsenic Chemistry Chemistry and Materials Science Inorganic Chemistry Metal-organic frameworks Organic Chemistry Polymer Sciences Side effects Toxicity Zeolites |
| title | Arsenic Polyoxotungstate-Zeolitic Imidazolate Framework-8 as a Potential Selective Anti-cancer Nano Platform |
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