Dearomative tandem annulation to access chiral indoline-fused bicyclo[2.2.2]octanes using modularly designed organocatalysts

Herein, we describe an asymmetric dearomative tandem annulation between 3-nitroindoles and 7-oxo-5-heptenals. The cascade reactions proceeded smoothly using modularly designed organocatalysts self-assembled from cinchona-squaramide and d -proline. As a result, a collection of enantioenriched indolin...

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Veröffentlicht in:	Organic Chemistry Frontiers 2023-02, Vol.10 (5), p.1237-1244
Hauptverfasser:	Zou, Wen-Lin, Liu, Yan-Qing, Li, Qing-Zhu, Kou, Xin-Xin, Huang, Hua, Tong, Rong-Sheng, Li, Jun-Long, Han, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric synthesis Asymmetry Cascade chemical reactions Chemical reactions Heterocyclic compounds Modular design Octanes Organic chemistry Self-assembly
Online-Zugang:	Volltext
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