158 The Association Between Sleep Spindles and Cognitive Function in Middle-Aged and Older Men: A Population-Based Cohort Study
Introduction Sleep spindles are thought to play an important role in learning and memory. The association between sleep spindles and cognitive function and the potential confounding influence of obstructive sleep apnea (OSA) is uncertain. We examined the cross-sectional association between sleep spi...
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| creator | Parker, Jesse Appleton, Sarah Melaku, Yohannes D’Rozario, Angela Wittert, Gary Catcheside, Peter Adams, Robert Vakulin, Andrew Martin, Sean |
| description | Introduction Sleep spindles are thought to play an important role in learning and memory. The association between sleep spindles and cognitive function and the potential confounding influence of obstructive sleep apnea (OSA) is uncertain. We examined the cross-sectional association between sleep spindles and cognitive function controlled for OSA in a sample of community dwelling middle-aged and older men. Methods Participants of the Florey Adelaide Male Ageing Study (n=477) underwent home-based polysomnography. These participants also completed the inspection time (IT) task, trail-making test part A (TMT-A) and part B (TMT-B), and Fuld object memory evaluation (FOME) test. Spindle metrics derived from sleep electroencephalography (n=356) included occurrence (total number) and fast (13-16 Hz) and slow (11-13 Hz) spindle density (number/minute) during N2 and N3 sleep. Linear regression models were adjusted for age, OSA, education, obesity, cardiovascular disease, diabetes, smoking, and alcohol risk. Results In covariate unadjusted analyses, higher spindle occurrence during N2 sleep was associated with better IT, TMT-A, TMT-B, and FOME performance (all p |
| doi_str_mv | 10.1093/sleep/zsab072.157 |
| format | Article |
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The association between sleep spindles and cognitive function and the potential confounding influence of obstructive sleep apnea (OSA) is uncertain. We examined the cross-sectional association between sleep spindles and cognitive function controlled for OSA in a sample of community dwelling middle-aged and older men. Methods Participants of the Florey Adelaide Male Ageing Study (n=477) underwent home-based polysomnography. These participants also completed the inspection time (IT) task, trail-making test part A (TMT-A) and part B (TMT-B), and Fuld object memory evaluation (FOME) test. Spindle metrics derived from sleep electroencephalography (n=356) included occurrence (total number) and fast (13-16 Hz) and slow (11-13 Hz) spindle density (number/minute) during N2 and N3 sleep. Linear regression models were adjusted for age, OSA, education, obesity, cardiovascular disease, diabetes, smoking, and alcohol risk. Results In covariate unadjusted analyses, higher spindle occurrence during N2 sleep was associated with better IT, TMT-A, TMT-B, and FOME performance (all p<0.05). Spindle density (fast and slow) during N2 and N3 sleep (slow spindles only) was associated with better inspection time, TMT-A, and TMT-B performance (all p<0.05). Fast spindle density during N2 sleep was also associated with better FOME performance (B=1.03, 95% CI [0.47, 1.59], p<0.05). In covariate adjusted analyses, higher spindle occurrence during N2 sleep was independently associated with better IT (B=-0.002, 95% CI [-0.004, 0.000], p=0.046), while fast spindle density during N3 sleep was independently associated with worse TMT-B performance (B=0.12, 95% CI [0.03, 0.21], p=0.011). Conclusion Specific sleep spindle metrics during N2 and N3 sleep were independently associated with better visual processing speed and worse executive attention, suggesting a differential association between cognitive function and spindles during N2 and N3 sleep. The utility of sleep spindles for predicting cognitive impairment needs investigation in prospective studies. Support (if any) National Health and Medical Research Foundation, Adelaide Institute for Sleep Health, Hospital Research Foundation, and ResMed Foundation.</description><identifier>ISSN: 0161-8105</identifier><identifier>EISSN: 1550-9109</identifier><identifier>DOI: 10.1093/sleep/zsab072.157</identifier><language>eng</language><publisher>Westchester: Oxford University Press</publisher><subject>Cognitive ability ; Cohort analysis ; Middle age ; Older people ; Population-based studies ; Sleep apnea</subject><ispartof>Sleep (New York, N.Y.), 2021-05, Vol.44 (Supplement_2), p.A64-A65</ispartof><rights>Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids></links><search><creatorcontrib>Parker, Jesse</creatorcontrib><creatorcontrib>Appleton, Sarah</creatorcontrib><creatorcontrib>Melaku, Yohannes</creatorcontrib><creatorcontrib>D’Rozario, Angela</creatorcontrib><creatorcontrib>Wittert, Gary</creatorcontrib><creatorcontrib>Catcheside, Peter</creatorcontrib><creatorcontrib>Adams, Robert</creatorcontrib><creatorcontrib>Vakulin, Andrew</creatorcontrib><creatorcontrib>Martin, Sean</creatorcontrib><title>158 The Association Between Sleep Spindles and Cognitive Function in Middle-Aged and Older Men: A Population-Based Cohort Study</title><title>Sleep (New York, N.Y.)</title><description>Introduction Sleep spindles are thought to play an important role in learning and memory. The association between sleep spindles and cognitive function and the potential confounding influence of obstructive sleep apnea (OSA) is uncertain. We examined the cross-sectional association between sleep spindles and cognitive function controlled for OSA in a sample of community dwelling middle-aged and older men. Methods Participants of the Florey Adelaide Male Ageing Study (n=477) underwent home-based polysomnography. These participants also completed the inspection time (IT) task, trail-making test part A (TMT-A) and part B (TMT-B), and Fuld object memory evaluation (FOME) test. Spindle metrics derived from sleep electroencephalography (n=356) included occurrence (total number) and fast (13-16 Hz) and slow (11-13 Hz) spindle density (number/minute) during N2 and N3 sleep. Linear regression models were adjusted for age, OSA, education, obesity, cardiovascular disease, diabetes, smoking, and alcohol risk. Results In covariate unadjusted analyses, higher spindle occurrence during N2 sleep was associated with better IT, TMT-A, TMT-B, and FOME performance (all p<0.05). Spindle density (fast and slow) during N2 and N3 sleep (slow spindles only) was associated with better inspection time, TMT-A, and TMT-B performance (all p<0.05). Fast spindle density during N2 sleep was also associated with better FOME performance (B=1.03, 95% CI [0.47, 1.59], p<0.05). In covariate adjusted analyses, higher spindle occurrence during N2 sleep was independently associated with better IT (B=-0.002, 95% CI [-0.004, 0.000], p=0.046), while fast spindle density during N3 sleep was independently associated with worse TMT-B performance (B=0.12, 95% CI [0.03, 0.21], p=0.011). Conclusion Specific sleep spindle metrics during N2 and N3 sleep were independently associated with better visual processing speed and worse executive attention, suggesting a differential association between cognitive function and spindles during N2 and N3 sleep. The utility of sleep spindles for predicting cognitive impairment needs investigation in prospective studies. Support (if any) National Health and Medical Research Foundation, Adelaide Institute for Sleep Health, Hospital Research Foundation, and ResMed Foundation.</description><subject>Cognitive ability</subject><subject>Cohort analysis</subject><subject>Middle age</subject><subject>Older people</subject><subject>Population-based studies</subject><subject>Sleep apnea</subject><issn>0161-8105</issn><issn>1550-9109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNotkE1PAjEQhhujiYj-AG9NPK_0Y0t3vQERNYFgAp6b7rYLJWu7trsavPjXLQuXmczMk2eSF4B7jB4xyuko1Fo3o98gC8TJI2b8AgwwYyjJ4_kSDBAe4yTDiF2DmxD2KM5pTgfgD7MMbnYaTkJwpZGtcRZOdfujtYXroxSuG2NVrQOUVsGZ21rTmm8N550te9pYuDQqEslkq1VPrWqlPVxq-wQn8N01Xd2Lk6kM-ujYOd_Cddupwy24qmQd9N25D8HH_Hkze00Wq5e32WSRlBhTnpAiR6zinFYEk0LxgsQtHTOuJZWsygtCGEGUM5WyXGWqiIXkaaYoloyWlA7Bw8nbePfV6dCKveu8jS8F4RmiJCWERwqfqNK7ELyuROPNp_QHgZE45iz6nMU5ZxFzpv817HHG</recordid><startdate>20210503</startdate><enddate>20210503</enddate><creator>Parker, Jesse</creator><creator>Appleton, Sarah</creator><creator>Melaku, Yohannes</creator><creator>D’Rozario, Angela</creator><creator>Wittert, Gary</creator><creator>Catcheside, Peter</creator><creator>Adams, Robert</creator><creator>Vakulin, Andrew</creator><creator>Martin, Sean</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20210503</creationdate><title>158 The Association Between Sleep Spindles and Cognitive Function in Middle-Aged and Older Men: A Population-Based Cohort Study</title><author>Parker, Jesse ; Appleton, Sarah ; Melaku, Yohannes ; D’Rozario, Angela ; Wittert, Gary ; Catcheside, Peter ; Adams, Robert ; Vakulin, Andrew ; Martin, Sean</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1137-2b905f773f212bd7b21373657ea3a5f9b22520375d459d8db9d82948d31a53c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cognitive ability</topic><topic>Cohort analysis</topic><topic>Middle age</topic><topic>Older people</topic><topic>Population-based studies</topic><topic>Sleep apnea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parker, Jesse</creatorcontrib><creatorcontrib>Appleton, Sarah</creatorcontrib><creatorcontrib>Melaku, Yohannes</creatorcontrib><creatorcontrib>D’Rozario, Angela</creatorcontrib><creatorcontrib>Wittert, Gary</creatorcontrib><creatorcontrib>Catcheside, Peter</creatorcontrib><creatorcontrib>Adams, Robert</creatorcontrib><creatorcontrib>Vakulin, Andrew</creatorcontrib><creatorcontrib>Martin, Sean</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parker, Jesse</au><au>Appleton, Sarah</au><au>Melaku, Yohannes</au><au>D’Rozario, Angela</au><au>Wittert, Gary</au><au>Catcheside, Peter</au><au>Adams, Robert</au><au>Vakulin, Andrew</au><au>Martin, Sean</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>158 The Association Between Sleep Spindles and Cognitive Function in Middle-Aged and Older Men: A Population-Based Cohort Study</atitle><jtitle>Sleep (New York, N.Y.)</jtitle><date>2021-05-03</date><risdate>2021</risdate><volume>44</volume><issue>Supplement_2</issue><spage>A64</spage><epage>A65</epage><pages>A64-A65</pages><issn>0161-8105</issn><eissn>1550-9109</eissn><abstract>Introduction Sleep spindles are thought to play an important role in learning and memory. The association between sleep spindles and cognitive function and the potential confounding influence of obstructive sleep apnea (OSA) is uncertain. We examined the cross-sectional association between sleep spindles and cognitive function controlled for OSA in a sample of community dwelling middle-aged and older men. Methods Participants of the Florey Adelaide Male Ageing Study (n=477) underwent home-based polysomnography. These participants also completed the inspection time (IT) task, trail-making test part A (TMT-A) and part B (TMT-B), and Fuld object memory evaluation (FOME) test. Spindle metrics derived from sleep electroencephalography (n=356) included occurrence (total number) and fast (13-16 Hz) and slow (11-13 Hz) spindle density (number/minute) during N2 and N3 sleep. Linear regression models were adjusted for age, OSA, education, obesity, cardiovascular disease, diabetes, smoking, and alcohol risk. Results In covariate unadjusted analyses, higher spindle occurrence during N2 sleep was associated with better IT, TMT-A, TMT-B, and FOME performance (all p<0.05). Spindle density (fast and slow) during N2 and N3 sleep (slow spindles only) was associated with better inspection time, TMT-A, and TMT-B performance (all p<0.05). Fast spindle density during N2 sleep was also associated with better FOME performance (B=1.03, 95% CI [0.47, 1.59], p<0.05). In covariate adjusted analyses, higher spindle occurrence during N2 sleep was independently associated with better IT (B=-0.002, 95% CI [-0.004, 0.000], p=0.046), while fast spindle density during N3 sleep was independently associated with worse TMT-B performance (B=0.12, 95% CI [0.03, 0.21], p=0.011). Conclusion Specific sleep spindle metrics during N2 and N3 sleep were independently associated with better visual processing speed and worse executive attention, suggesting a differential association between cognitive function and spindles during N2 and N3 sleep. The utility of sleep spindles for predicting cognitive impairment needs investigation in prospective studies. Support (if any) National Health and Medical Research Foundation, Adelaide Institute for Sleep Health, Hospital Research Foundation, and ResMed Foundation.</abstract><cop>Westchester</cop><pub>Oxford University Press</pub><doi>10.1093/sleep/zsab072.157</doi><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Cognitive ability Cohort analysis Middle age Older people Population-based studies Sleep apnea |
| title | 158 The Association Between Sleep Spindles and Cognitive Function in Middle-Aged and Older Men: A Population-Based Cohort Study |
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