Maternal liver damage induced by cadmium exposure in pregnant mice through hypoxia inducible factor-1α-mediated upregulation in DRP1

Background Mitochondrial dynamin-related protein 1 (DRP1) regulates mitochondrial division and plays an important role in maintaining hepatocyte function. However, the role of DRP1 in cadmium exposure-induced maternal liver damage in pregnant mice remains unclear. Objective To investigate the role a...

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Veröffentlicht in:	Huan jing yu zhi ye yi xue = Journal of environmental & occupational medicine 2023-01, Vol.40 (1), p.68
Hauptverfasser:	Dai, Limin, Zhu, Hualong, Xiong, Yongwei, Liu, Weibo, Zhou, Guoxiang, Zhang, Shuang, Ling, Zhengjia, Tan, Lulu, Zhang, Jin, Zhang, Yufeng, Fu, Yiting, Li, Daixin, Wang, Hua
Format:	Artikel
Sprache:	chi
Schlagworte:	Alanine Alanine transaminase Animal research Aspartate aminotransferase Cadmium Cadmium chloride Damage Dynamin Experiments Exposure Fetuses Hepatocytes Hypoxia Hypoxia-inducible factor 1a Liver Mitochondria Necrosis Oxidative phosphorylation Phosphorylation Pregnancy Pretreatment Proteins siRNA Transaminases Uterus Western blotting
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