Direct Access to 9/6‐Fused Cycles via Sequential Hydride Shift Mediated Double C(sp3)−H Bond Functionalization

We have developed a sequential hydride shift process involving a [1,8]‐hydride shift. When cinnamylidene malonates having a biphenyl core were treated with 30 mol% Yb(OTf)3 and 10 mol% iPr2NEt, the desired sequential [1,8]‐[1,5]‐hydride shift process proceeded smoothly to afford synthetically challe...

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Veröffentlicht in:	Advanced synthesis & catalysis 2023-02, Vol.365 (4), p.502-507
Hauptverfasser:	Nakamura, Issei, Anada, Masahiro, Sueki, Shunsuke, Makino, Kosho, Mori, Keiji
Format:	Artikel
Sprache:	eng
Schlagworte:	fused cycles hydride shift Hydrides internal redox reaction nine-membered ring Piperidine remote functionalization
Online-Zugang:	Volltext
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