Stereoselective Reduction of α‑Fluoro-β-ketoesters: Ketoreductases and Dynamic Reductive Kinetic Resolution

Stereoselective reduction of ketones to alcohols using baker’s yeast is a classic experiment in the undergraduate laboratory. Here we illustrate the reduction of racemic ethyl 2-fluoro-3-oxobutanoate to the corresponding alcohol using a set of four commercially available ketoreductases (KREDs). The...

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Veröffentlicht in:	Journal of chemical education 2023-02, Vol.100 (2), p.745-750
Hauptverfasser:	Green, Thomas K., Vanagel, Matthew, Damarancha, Anil, Showalter, Brandon, Novick, Scott J., Chagger Maniar, Harvinder
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohols Baking yeast Chemistry Ketones Kinetics Laboratories NMR NMR spectroscopy Nuclear magnetic resonance Reduction Stereoisomerism Stereoselectivity Yeasts
Online-Zugang:	Volltext
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