The Biosynthetic Gene Cluster of Mushroom‐Derived Antrocin Encodes Two Dual‐Functional Haloacid Dehalogenase‐like Terpene Cyclases

(−)‐Antrocin (1), produced by the medicinal mushroom Antrodia cinnamomea, is a potent antiproliferative compound. The biosynthetic gene cluster of 1 was identified, and the pathway was characterized by heterologous expression. We characterized a haloacid dehalogenase‐like terpene cyclase AncC that b...

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Veröffentlicht in:	Angewandte Chemie 2023-02, Vol.135 (9), p.n/a
Hauptverfasser:	Chen, Tzu‐Ho, Chen, Chien‐Ting, Lee, Chi‐Fang, Huang, Rou‐Jie, Chen, Kuan‐Lin, Lu, Yuan‐Chun, Liang, Suh‐Yuen, Pham, Mai‐Truc, Rao, Yerra Koteswara, Wu, Shih‐Hsiung, Chein, Rong‐Jie, Lin, Hsiao‐Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineutrophil cytoplasmic antibodies Biosynthesis Chemistry Domains Medicinal Mushrooms Mushrooms Mutagenesis Natural Products Pyrophosphatase Terpene Cyclases Terpenes
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