Astrocytic aryl hydrocarbon receptor mediates chronic kidney disease‐associated mental disorders involving GLT1 hypofunction and neuronal activity enhancement in the mouse brain

Chronic kidney disease (CKD)‐associated mental disorders have been attributed to the excessive accumulation of hemodialysis‐resistant indoxyl‐3‐sulfate (I3S) in the brain. I3S not only induces oxidative stress but is also a potent endogenous agonist of the aryl hydrocarbon receptor (AhR). Here, we i...

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Veröffentlicht in:	Glia 2023-04, Vol.71 (4), p.1057-1080
Hauptverfasser:	Huang, Yu‐Jie, Hung, Chia‐Chi, Hsu, Pei‐Chien, Lee, Po‐Yi, Tsai, Yen‐An, Hsin, Yu‐Chiao, Lee, Xie‐Ting, Chou, Chia‐Cheng, Chen, Mei‐Lien, Tarng, Der‐Cherng, Lee, Yi‐Hsuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aromatic compounds aryl hydrocarbon receptor astrocyte reactivation Astrocytes Astrocytes - metabolism Blood levels Brain chronic kidney disease Cortex (cingulate) Excitatory Amino Acid Transporter 2 - metabolism Glial fibrillary acidic protein glutamate transporter 1 Glutamic acid transporter Hemodialysis Hippocampus Hippocampus - metabolism Hydrocarbons Indican - metabolism Kidney diseases Kidneys Mental disorders Mental Disorders - etiology Mental Disorders - metabolism Mice Mice, Knockout Microenvironments Nephrectomy neuronal activity Neuronal-glial interactions Oxidants Oxidative stress Oxidizing agents Receptors Receptors, Aryl Hydrocarbon - agonists Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Reduction Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - metabolism
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