Disseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report
Porokeratosis encompass a group of acquired and familial, preneoplastic, keratinization disorders, clinically characterized by atrophic macules or patches with a peripheral keratotic rim, the cornoid lamella. Genetic background is recognized as crucial in its pathophysiology, while immunosuppression...
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| Veröffentlicht in: | Australasian journal of dermatology 2023-02, Vol.64 (1), p.e72-e75 |
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| container_title | Australasian journal of dermatology |
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| creator | Romagnuolo, Maurizio Riva, Davide Alberti Violetti, Silvia Di Benedetto, Alessandra Barberi, Francesco Moltrasio, Chiara |
| description | Porokeratosis encompass a group of acquired and familial, preneoplastic, keratinization disorders, clinically characterized by atrophic macules or patches with a peripheral keratotic rim, the cornoid lamella. Genetic background is recognized as crucial in its pathophysiology, while immunosuppression and ultraviolet radiation represent triggering factors. We report the case of a woman who developed disseminate superficial actinic porokeratosis following the intake of hydroxyurea for a polycythaemia vera. Clinical, dermoscopic and histopathology data are showed, and the role of drug as a second‐hit mutation trigger is discussed. |
| doi_str_mv | 10.1111/ajd.13943 |
| format | Article |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | adverse effect Case reports Female genetic analysis Humans Hydroxyurea Hydroxyurea - adverse effects Immunosuppression Keratinization Keratosis, Actinic Porokeratosis Porokeratosis - chemically induced Porokeratosis - drug therapy Porokeratosis - pathology squamous cells neoplasm mevalonate kinase deficiency Ultraviolet radiation Ultraviolet Rays |
| title | Disseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report |
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