Fabrication of a photo- and pH-sensitive micelle by self-assembly of azobenzene polyglycerol for anticancer drug delivery
Smart materials can respond to external physical or chemical stimuli in controlled conditions. Azo dyes are widely used in industry and medicine due to their physicochemical properties. The photoisomerization ability of azo compounds has made them attractive candidates for the design of compounds wi...
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| Veröffentlicht in: | Monatshefte für Chemie 2023-02, Vol.154 (2), p.259-265 |
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| creator | Rafiee, Zeinab Bodaghi, Ali Omidi, Sakineh |
| description | Smart materials can respond to external physical or chemical stimuli in controlled conditions. Azo dyes are widely used in industry and medicine due to their physicochemical properties. The photoisomerization ability of azo compounds has made them attractive candidates for the design of compounds with photo-responsive properties and use in drug delivery. In this work, a light-sensitive polymer containing azobenzene as the core and hyperbranched polyglycerol as the shell (called Azo-HPG) was synthesized via anionic ring-opening polymerization. The structure of Azo-HPG was analyzed by FT-IR, NMR, DLS, and GPC. The ability of polymer in the delivery of doxorubicin was investigated under UV irradiation and different pH conditions.
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| doi_str_mv | 10.1007/s00706-023-03036-9 |
| format | Article |
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| subjects | Analytical Chemistry Azo compounds Chemistry Chemistry and Materials Science Chemistry/Food Science Doxorubicin Inorganic Chemistry Micelles NMR Nuclear magnetic resonance Organic Chemistry Original Paper Physical Chemistry Polyglycerols Polymers Ring opening polymerization Self-assembly Smart materials Theoretical and Computational Chemistry Ultraviolet radiation |
| title | Fabrication of a photo- and pH-sensitive micelle by self-assembly of azobenzene polyglycerol for anticancer drug delivery |
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