One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst
The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic s...
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Veröffentlicht in: | Monatshefte für Chemie 2023-02, Vol.154 (2), p.231-237 |
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creator | El Hallaoui, Achraf Merroun, Youssef Chehab, Soukaina Ghailane, Rachida Souizi, Abdelaziz |
description | The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic systems, we present in this paper a highly efficient one-step synthesis of triarylpyridine by Al/Ag
3
PO
4
phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines.
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doi_str_mv | 10.1007/s00706-022-03023-6 |
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3
PO
4
phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines.
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3
PO
4
phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines.
Graphical abstract</description><subject>Acetophenone</subject><subject>Aldehydes</subject><subject>Ammonium acetate</subject><subject>Analytical Chemistry</subject><subject>Aromatic compounds</subject><subject>Bimetals</subject><subject>Catalysis</subject><subject>Catalysts</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Chemists</subject><subject>Heterocyclic compounds</subject><subject>Inorganic Chemistry</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Phosphates</subject><subject>Physical Chemistry</subject><subject>Pyridines</subject><subject>Silver compounds</subject><subject>Theoretical and Computational Chemistry</subject><issn>0026-9247</issn><issn>1434-4475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc-O2yAQxlHVSk23fYGeRuo1dDFgvByjVf9JK6WH9owwHiesbHCB7Mrv1ocrSSr11svMoPl930h8hLxv2MeGse4218IUZZxTJhgXVL0gm0YKSaXs2pdkwxhXVHPZvSZvcn5k9S2Z2JDf-4B0iQXyGsoRs88QR-BbuVW0JG_TOi1r8oMPmKFfwa1uii6GAUO2xccAPZZnxABnFOw04HEdcAvWYYnLEUMMCAMm_1Txp_MiDGDnOQZ_mi-ULQin7MMBdtPt7iC-7yXYDBYCPl_oQzr7936u7DR5B87WYc3lLXk12inju7_9hvz8_OnH_Vf6sP_y7X73QJ1odKGcoWBKDq0QSgvXjloJq4XW_cj7sXWNsndjy3rXc2tZJ9teaXnnGodN5RQXN-TD1XdJ8dcJczGP8ZRCPWl41ymmuk6LSvEr5VLMOeFoluTn-i2mYeackrmmZGpK5pKSUVUkrqJc4XDA9M_6P6o_GqeXqw</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>El Hallaoui, Achraf</creator><creator>Merroun, Youssef</creator><creator>Chehab, Soukaina</creator><creator>Ghailane, Rachida</creator><creator>Souizi, Abdelaziz</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-5352-4260</orcidid></search><sort><creationdate>20230201</creationdate><title>One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst</title><author>El Hallaoui, Achraf ; Merroun, Youssef ; Chehab, Soukaina ; Ghailane, Rachida ; Souizi, Abdelaziz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-20e3064d533693c5f963a9399bf2bf5c16a8f50bcb2aa0745b6948c1ce13a9623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acetophenone</topic><topic>Aldehydes</topic><topic>Ammonium acetate</topic><topic>Analytical Chemistry</topic><topic>Aromatic compounds</topic><topic>Bimetals</topic><topic>Catalysis</topic><topic>Catalysts</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Chemists</topic><topic>Heterocyclic compounds</topic><topic>Inorganic Chemistry</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Phosphates</topic><topic>Physical Chemistry</topic><topic>Pyridines</topic><topic>Silver compounds</topic><topic>Theoretical and Computational Chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Hallaoui, Achraf</creatorcontrib><creatorcontrib>Merroun, Youssef</creatorcontrib><creatorcontrib>Chehab, Soukaina</creatorcontrib><creatorcontrib>Ghailane, Rachida</creatorcontrib><creatorcontrib>Souizi, Abdelaziz</creatorcontrib><collection>CrossRef</collection><jtitle>Monatshefte für Chemie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Hallaoui, Achraf</au><au>Merroun, Youssef</au><au>Chehab, Soukaina</au><au>Ghailane, Rachida</au><au>Souizi, Abdelaziz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst</atitle><jtitle>Monatshefte für Chemie</jtitle><stitle>Monatsh Chem</stitle><date>2023-02-01</date><risdate>2023</risdate><volume>154</volume><issue>2</issue><spage>231</spage><epage>237</epage><pages>231-237</pages><issn>0026-9247</issn><eissn>1434-4475</eissn><abstract>The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic systems, we present in this paper a highly efficient one-step synthesis of triarylpyridine by Al/Ag
3
PO
4
phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines.
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subjects | Acetophenone Aldehydes Ammonium acetate Analytical Chemistry Aromatic compounds Bimetals Catalysis Catalysts Chemistry Chemistry and Materials Science Chemistry/Food Science Chemists Heterocyclic compounds Inorganic Chemistry Organic Chemistry Original Paper Phosphates Physical Chemistry Pyridines Silver compounds Theoretical and Computational Chemistry |
title | One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst |
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