One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst

The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Monatshefte für Chemie 2023-02, Vol.154 (2), p.231-237
Hauptverfasser: El Hallaoui, Achraf, Merroun, Youssef, Chehab, Soukaina, Ghailane, Rachida, Souizi, Abdelaziz
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 237
container_issue 2
container_start_page 231
container_title Monatshefte für Chemie
container_volume 154
creator El Hallaoui, Achraf
Merroun, Youssef
Chehab, Soukaina
Ghailane, Rachida
Souizi, Abdelaziz
description The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic systems, we present in this paper a highly efficient one-step synthesis of triarylpyridine by Al/Ag 3 PO 4 phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines. Graphical abstract
doi_str_mv 10.1007/s00706-022-03023-6
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2776067793</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2776067793</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-20e3064d533693c5f963a9399bf2bf5c16a8f50bcb2aa0745b6948c1ce13a9623</originalsourceid><addsrcrecordid>eNp9kc-O2yAQxlHVSk23fYGeRuo1dDFgvByjVf9JK6WH9owwHiesbHCB7Mrv1ocrSSr11svMoPl930h8hLxv2MeGse4218IUZZxTJhgXVL0gm0YKSaXs2pdkwxhXVHPZvSZvcn5k9S2Z2JDf-4B0iQXyGsoRs88QR-BbuVW0JG_TOi1r8oMPmKFfwa1uii6GAUO2xccAPZZnxABnFOw04HEdcAvWYYnLEUMMCAMm_1Txp_MiDGDnOQZ_mi-ULQin7MMBdtPt7iC-7yXYDBYCPl_oQzr7936u7DR5B87WYc3lLXk12inju7_9hvz8_OnH_Vf6sP_y7X73QJ1odKGcoWBKDq0QSgvXjloJq4XW_cj7sXWNsndjy3rXc2tZJ9teaXnnGodN5RQXN-TD1XdJ8dcJczGP8ZRCPWl41ymmuk6LSvEr5VLMOeFoluTn-i2mYeackrmmZGpK5pKSUVUkrqJc4XDA9M_6P6o_GqeXqw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2776067793</pqid></control><display><type>article</type><title>One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst</title><source>SpringerLink Journals - AutoHoldings</source><creator>El Hallaoui, Achraf ; Merroun, Youssef ; Chehab, Soukaina ; Ghailane, Rachida ; Souizi, Abdelaziz</creator><creatorcontrib>El Hallaoui, Achraf ; Merroun, Youssef ; Chehab, Soukaina ; Ghailane, Rachida ; Souizi, Abdelaziz</creatorcontrib><description>The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic systems, we present in this paper a highly efficient one-step synthesis of triarylpyridine by Al/Ag 3 PO 4 phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines. Graphical abstract</description><identifier>ISSN: 0026-9247</identifier><identifier>EISSN: 1434-4475</identifier><identifier>DOI: 10.1007/s00706-022-03023-6</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Acetophenone ; Aldehydes ; Ammonium acetate ; Analytical Chemistry ; Aromatic compounds ; Bimetals ; Catalysis ; Catalysts ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Chemists ; Heterocyclic compounds ; Inorganic Chemistry ; Organic Chemistry ; Original Paper ; Phosphates ; Physical Chemistry ; Pyridines ; Silver compounds ; Theoretical and Computational Chemistry</subject><ispartof>Monatshefte für Chemie, 2023-02, Vol.154 (2), p.231-237</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-20e3064d533693c5f963a9399bf2bf5c16a8f50bcb2aa0745b6948c1ce13a9623</citedby><cites>FETCH-LOGICAL-c319t-20e3064d533693c5f963a9399bf2bf5c16a8f50bcb2aa0745b6948c1ce13a9623</cites><orcidid>0000-0001-5352-4260</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00706-022-03023-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00706-022-03023-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>El Hallaoui, Achraf</creatorcontrib><creatorcontrib>Merroun, Youssef</creatorcontrib><creatorcontrib>Chehab, Soukaina</creatorcontrib><creatorcontrib>Ghailane, Rachida</creatorcontrib><creatorcontrib>Souizi, Abdelaziz</creatorcontrib><title>One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst</title><title>Monatshefte für Chemie</title><addtitle>Monatsh Chem</addtitle><description>The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic systems, we present in this paper a highly efficient one-step synthesis of triarylpyridine by Al/Ag 3 PO 4 phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines. Graphical abstract</description><subject>Acetophenone</subject><subject>Aldehydes</subject><subject>Ammonium acetate</subject><subject>Analytical Chemistry</subject><subject>Aromatic compounds</subject><subject>Bimetals</subject><subject>Catalysis</subject><subject>Catalysts</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Chemists</subject><subject>Heterocyclic compounds</subject><subject>Inorganic Chemistry</subject><subject>Organic Chemistry</subject><subject>Original Paper</subject><subject>Phosphates</subject><subject>Physical Chemistry</subject><subject>Pyridines</subject><subject>Silver compounds</subject><subject>Theoretical and Computational Chemistry</subject><issn>0026-9247</issn><issn>1434-4475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc-O2yAQxlHVSk23fYGeRuo1dDFgvByjVf9JK6WH9owwHiesbHCB7Mrv1ocrSSr11svMoPl930h8hLxv2MeGse4218IUZZxTJhgXVL0gm0YKSaXs2pdkwxhXVHPZvSZvcn5k9S2Z2JDf-4B0iQXyGsoRs88QR-BbuVW0JG_TOi1r8oMPmKFfwa1uii6GAUO2xccAPZZnxABnFOw04HEdcAvWYYnLEUMMCAMm_1Txp_MiDGDnOQZ_mi-ULQin7MMBdtPt7iC-7yXYDBYCPl_oQzr7936u7DR5B87WYc3lLXk12inju7_9hvz8_OnH_Vf6sP_y7X73QJ1odKGcoWBKDq0QSgvXjloJq4XW_cj7sXWNsndjy3rXc2tZJ9teaXnnGodN5RQXN-TD1XdJ8dcJczGP8ZRCPWl41ymmuk6LSvEr5VLMOeFoluTn-i2mYeackrmmZGpK5pKSUVUkrqJc4XDA9M_6P6o_GqeXqw</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>El Hallaoui, Achraf</creator><creator>Merroun, Youssef</creator><creator>Chehab, Soukaina</creator><creator>Ghailane, Rachida</creator><creator>Souizi, Abdelaziz</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-5352-4260</orcidid></search><sort><creationdate>20230201</creationdate><title>One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst</title><author>El Hallaoui, Achraf ; Merroun, Youssef ; Chehab, Soukaina ; Ghailane, Rachida ; Souizi, Abdelaziz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-20e3064d533693c5f963a9399bf2bf5c16a8f50bcb2aa0745b6948c1ce13a9623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acetophenone</topic><topic>Aldehydes</topic><topic>Ammonium acetate</topic><topic>Analytical Chemistry</topic><topic>Aromatic compounds</topic><topic>Bimetals</topic><topic>Catalysis</topic><topic>Catalysts</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Chemists</topic><topic>Heterocyclic compounds</topic><topic>Inorganic Chemistry</topic><topic>Organic Chemistry</topic><topic>Original Paper</topic><topic>Phosphates</topic><topic>Physical Chemistry</topic><topic>Pyridines</topic><topic>Silver compounds</topic><topic>Theoretical and Computational Chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Hallaoui, Achraf</creatorcontrib><creatorcontrib>Merroun, Youssef</creatorcontrib><creatorcontrib>Chehab, Soukaina</creatorcontrib><creatorcontrib>Ghailane, Rachida</creatorcontrib><creatorcontrib>Souizi, Abdelaziz</creatorcontrib><collection>CrossRef</collection><jtitle>Monatshefte für Chemie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Hallaoui, Achraf</au><au>Merroun, Youssef</au><au>Chehab, Soukaina</au><au>Ghailane, Rachida</au><au>Souizi, Abdelaziz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst</atitle><jtitle>Monatshefte für Chemie</jtitle><stitle>Monatsh Chem</stitle><date>2023-02-01</date><risdate>2023</risdate><volume>154</volume><issue>2</issue><spage>231</spage><epage>237</epage><pages>231-237</pages><issn>0026-9247</issn><eissn>1434-4475</eissn><abstract>The 2,4,6-trisubstituted pyridines constitute an important family of heterocyclic compounds widely used in industry, especially in pharmaceuticals, making their preparation a crucial challenge for organic chemists. In continuation of our approach in the preparation and development of new catalytic systems, we present in this paper a highly efficient one-step synthesis of triarylpyridine by Al/Ag 3 PO 4 phosphate bimetallic catalysis from the condensation of acetophenone derivatives, aryl aldehydes, and ammonium acetate under mild and environmentally friendly conditions. This methodology offers several advantages: excellent yields and shorter reaction times. In addition, the catalyst exhibited remarkable reusable activity. Compared to previous methods, our procedure allows a very flexible, more straightforward, faster, and more efficient preparation of substituted pyridines. Graphical abstract</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><doi>10.1007/s00706-022-03023-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5352-4260</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0026-9247
ispartof Monatshefte für Chemie, 2023-02, Vol.154 (2), p.231-237
issn 0026-9247
1434-4475
language eng
recordid cdi_proquest_journals_2776067793
source SpringerLink Journals - AutoHoldings
subjects Acetophenone
Aldehydes
Ammonium acetate
Analytical Chemistry
Aromatic compounds
Bimetals
Catalysis
Catalysts
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chemists
Heterocyclic compounds
Inorganic Chemistry
Organic Chemistry
Original Paper
Phosphates
Physical Chemistry
Pyridines
Silver compounds
Theoretical and Computational Chemistry
title One-pot synthesis of 2,4,6-triarylpyridines by cyclocondensation between aryl aldehyde, acetophenone derivative, and ammonium acetate using Al/Ag3PO4 as a new and green bimetallic catalyst
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T09%3A36%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=One-pot%20synthesis%20of%202,4,6-triarylpyridines%20by%20cyclocondensation%20between%20aryl%20aldehyde,%20acetophenone%20derivative,%20and%20ammonium%20acetate%20using%20Al/Ag3PO4%20as%20a%20new%20and%20green%20bimetallic%20catalyst&rft.jtitle=Monatshefte%20f%C3%BCr%20Chemie&rft.au=El%20Hallaoui,%20Achraf&rft.date=2023-02-01&rft.volume=154&rft.issue=2&rft.spage=231&rft.epage=237&rft.pages=231-237&rft.issn=0026-9247&rft.eissn=1434-4475&rft_id=info:doi/10.1007/s00706-022-03023-6&rft_dat=%3Cproquest_cross%3E2776067793%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2776067793&rft_id=info:pmid/&rfr_iscdi=true