Differential role of Pax6 and its interaction with Shh–Gli1–IDH2 axis in regulation of glioma growth and chemoresistance

Glioma is a major brain tumor, and the associated mortality rate is very high. Contemporary therapies provide a chance of survival for 9–12 months. Therefore, a novel approach is essential to improve the survival rate. Sonic hedgehog (Shh) cell signaling is critical for early development in various...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2023-02, Vol.37 (2), p.e23241-n/a
Hauptverfasser:	Farheen, Shirin, Ahmed, Swalih P., Mariyath P. M., Mubeena, Kausar, Tasneem, Hoda, Md. Fakhrul, Arif, Sayeedul H., Nayeem, Shahid M., Ali, Asif, Chosdol, Kunzang, Shahi, Mehdi H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain cancer Brain Neoplasms - metabolism Brain tumors Cell proliferation Cell signaling Chemoresistance Disease resistance Drug resistance Drug Resistance, Neoplasm Gli1 Glioma Glioma - drug therapy Glioma - metabolism Glioma cells Hedgehog protein Hedgehog Proteins - metabolism Humans IDH2 Immunohistochemistry Isocitrate dehydrogenase Kinases Molecular docking molecular dynamic simulation (MDS) Molecular dynamics Pax6 Pax6 protein PAX6 Transcription Factor - genetics protein docking Proteins Shh Signal transduction Signaling Survival Temozolomide Temozolomide - pharmacology Transcriptomes Tumors Zinc Finger Protein GLI1 - genetics Zinc Finger Protein GLI1 - metabolism Zinc Finger Protein GLI1 - therapeutic use
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