Therapeutic window and neuroprotection with 7,8‐Dihydroxyflavone in degenerating retinal ganglion cells after excitotoxic damage

Purpose: To evaluate the optimal therapeutic window of 7,8‐Dihydroxyflavone (DHF), an agonist of TrkB receptor, as a neuroprotectant for degenerative retinal ganglion cells (RGCs) due to an excitotoxic damage with N‐methyl‐D‐aspartic acid (NMDA). Methods: In adult albino Sprague–Dawley rats, NMDA (5...

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Veröffentlicht in:	Acta ophthalmologica (Oxford, England) England), 2022-12, Vol.100 (S275), p.n/a
Hauptverfasser:	Galindo‐Romero, Caridad, Asís‐Martínez, Javier, Navarro, Manuel Angel Salinas, Di Pierdomenico, Johnny, Muñoz, María Norte, Bernal‐Garro, Jose M., Ortega, Alejandro Gallego, Vidal‐Villegas, Beatriz, Perez, Maria Paz Villegas, Vidal‐Sanz, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspartic acid Brn-3 protein Degeneration Excitotoxicity Injection Neuroprotection Neuroprotective agents Retina Retinal ganglion cells Sodium chloride Spatial distribution TrkB receptors
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