Brain‐derived neurotrophic factor‐mimetic compounds in biodegradable microspheres as novel neuroprotective approaches for retinal diseases

Purpose: Neuroprotectants can modulate cell survival and molecular pathways common to several inherited retinal degenerations (IRD). Among them, 7,8‐dihydroxyflavone (7,8‐DHF), a brain‐derived neurotrophic factor (BDNF) mimetic, proved to rescue vision in dyeucd6 zebrafish model of IRD by upregulati...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Acta ophthalmologica (Oxford, England) England), 2022-12, Vol.100 (S275), p.n/a
Hauptverfasser:	Brugnera, Marco, Messina, Flavia, Reynolds, Alison, O'Reilly, Niall, Kalesnykas, Giedrius, Herrero‐Vanrell, Rocío, Kennedy, Breandán, Bravo‐Osuna, Irene
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradability Brain-derived neurotrophic factor Cell survival Encapsulation Evaporation Freeze drying Microspheres Neuroprotection Polylactide-co-glycolide Recovery of function Retina Retinal degeneration Signal transduction TrkB receptors Visual perception
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!