Electrochemical Hydroalkylation of Quinoxalin‐2(1H)‐ones with Alkyl Halides

We reported herein an electrochemically reductive alkylation, allylation and propargylation of quinoxalin‐2(1H)‐ones with haloalkanes. In an undivided cell, treatment of quinoxalin‐2(1H)‐ones and alkyl halides with constant current, a wide range of 3‐alkylated‐3,4‐dihydroquinoxalin‐2(1H)‐one and its...

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Veröffentlicht in:	Advanced synthesis & catalysis 2023-02, Vol.365 (3), p.318-322
Hauptverfasser:	Qiu, Zhihong, Huang, Xianting, Wu, Jintao, Liu, Zhong‐Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	alkylation Allyl compounds allylation Chemical reactions electrochemistry Halides quinoxalin-2(1H)-ones radical reactions Reductive alkylation
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container_title	Advanced synthesis & catalysis
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creator	Qiu, Zhihong Huang, Xianting Wu, Jintao Liu, Zhong‐Quan
description	We reported herein an electrochemically reductive alkylation, allylation and propargylation of quinoxalin‐2(1H)‐ones with haloalkanes. In an undivided cell, treatment of quinoxalin‐2(1H)‐ones and alkyl halides with constant current, a wide range of 3‐alkylated‐3,4‐dihydroquinoxalin‐2(1H)‐one and its derivatives can be isolated in 25–87% yields.
doi_str_mv	10.1002/adsc.202201241
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subjects	alkylation Allyl compounds allylation Chemical reactions electrochemistry Halides quinoxalin-2(1H)-ones radical reactions Reductive alkylation
title	Electrochemical Hydroalkylation of Quinoxalin‐2(1H)‐ones with Alkyl Halides
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