Eudragit®-based nanoparticles for controlled release through topical use

Eudragit® products are composed of acrylic acid, methacrylic acid, and their esters, which can be used to assemble various drug delivery systems, including polymeric nanoparticles. These nanoparticles make it possible to control the delivery of bioactive molecules (locally and release rate), which is not possible with conventional formulations. In this work, we reviewed the literature to observe the development of nanoparticles for topical application using the different types of Eudragit®. The development of nanoparticles using Eudragit® is known for its reproducible techniques that produce stable and biocompatible particles. The results show that the choice of the polymer was mainly made by the physicochemical properties, looking for polymers that can specifically enhance or avoid the interaction of the nanocarrier with the skin and mucous membranes. Nanoparticles with positive charge and nanometric size interact with physiological membranes to enhance drug efficacy, while particles with negative surface area and pH-dependent release mechanisms aim to reduce adverse effects. These different applications of Eudragit® polymeric nanoparticles could lead to novel products on the market.